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Nat Comm | Zhang Xiaolong/Liu Xianguo collaborate to reveal the regulatory mechanism of thermal nociception
Time of Update: 2021-04-27
Recently, Associate Professor Zhang Xiaolong of the Medical Research Center of Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences) and Professor Liu Xianguo of the Pain Research Center of Sun Yat-sen University jointly published a research paper entitled ATF4 selectively regulates heat nociception and contributes to kinesin-mediated TRPM3 trafficking in Nature Communications It was found that ATF4 binds to ion channel TRPM3 and kinesin KIF17, and the three form a complex.
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I was born with a stroke and lacked a quarter of the cerebral cortex, but I lived a normal life for 22 years... The Lancet sub-Journal reported a rare brain "remodeling"
Time of Update: 2021-04-27
” Screenshot source: The awkward right hand on The Lancet Neurology baseball field first noticed Daniel’s body abnormality.
" Daniel's MRI scan showed that a severe stroke during his infancy caused injuries to both sides of his brain.
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NEJM: Inner ear implant device improves daily balance and quality of life in patients with vestibular dysfunction
Time of Update: 2021-04-27
This study is the first to show in daily life that artificial implantation devices have significantly improved the patient's balance, gait stability and quality of life through long-term follow-up, marking an important new development in the field of vestibular medicine.
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The BMI1 gene prevents Alzheimer’s disease by inhibiting the production of four-stranded DNA in neurons
Time of Update: 2021-04-27
In this Nature Communications paper, the research team found that G-quadruplex structures accumulate in the brain neurons of Alzheimer's patients, but not in the brains of healthy elderly people.
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Cell Metab | The brain regulation mechanism behind "gluttony"
Time of Update: 2021-04-27
On the basis of neural circuit research methods, it is revealed that a type of specific Nos1-expressing neurons that project from the insular cortex to the central amygdala promotes the neural mechanism of overfeeding, so as to better help us understand the specific environment The neurobiological mechanism behind "bulimia" behavior.
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How can I sleep only 4 hours a night and be energetic?
Time of Update: 2021-04-27
In October 2020, the team of Fu Huihui and Louis J Ptáček from the University of California, San Francisco, published a research paper entitled Mutations in Metabotropic Glutamate Receptor 1 Contribute to Natural Short Sleep Trait in the Current Biology magazine, a sub-Journal of Cell.
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Successfully cultivated the "mini brain" synchronized with the baby's brain development
Time of Update: 2021-04-27
com/tags/%E5%B9%B2%E7%BB%86%E8%83%9E/">The maturation of the three-dimensional "mini brain" organoids derived from bioon.
com/tags/%E5%B9%B2%E7%BB%86%E8%83%9E/">stem cells is surprisingly similar to the development of the human brain.
html">stem cells have the potential to revolutionize medical practice because it gives researchers an unprecedented understanding of how complex organs, including the brain, develop and how humans respond to diseases.
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Treat "gradual freezing"!
Time of Update: 2021-04-24
Recently, the company announced that it has initiated a phase 3 clinical trial of ION363 for the treatment of amyotrophic lateral sclerosis (ALS) caused by the FUS mutation.
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Sub-Journal of Nature: The latest research reveals why you always feel hungry and eat more unconsciously, leading to weight loss failure
Time of Update: 2021-04-24
This study found that the degree of "sugar dips" after eating has a huge impact on hunger and appetite, which will help people understand and control weight and maintain long-term health.
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"Dopamine" is a familiar and unfamiliar word, do you understand it?
Time of Update: 2021-04-24
Clinical application of dopamine drugs ①Dopamine-stimulates the sympathetic nervous system adrenal receptors (α, β receptors) and the effects of dopamine receptors located in the kidney, mesenteric, coronary and cerebral arteries, used to treat heart failure, shock and sepsis Disease and so on.
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The new crown virus is really "upper" | 1/3 of patients still have neurological or mental illness 6 months later
Time of Update: 2021-04-24
The results showed that more than one-third Patients with new crowns were diagnosed with neurological or mental illnesses within six months of being infected with new crowns.
The results show that compared with influenza and respiratory infections, the new crown does bring a higher risk of neurological and mental diseases.
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The brain health of one-third of people infected with the new crown is affected, and the "Lancet" publication publishes data on 230,000 patients
Time of Update: 2021-04-24
"This is real-world data collected from a large number of patients, which confirms that the diagnosis rate of mental illness after the new crown is high, and it can also cause serious diseases that affect the nervous system (such as stroke and dementia).
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Li Liang/Zeng Ke from Nanjing University reveals the molecular mechanism of microglia "swallowing" excessive synapses
Time of Update: 2021-04-24
In addition, the number of CD47-positive synapses in SIRPα-cKO mice increased, indicating that synapses that did not express CD47 were more likely to be phagocytosed by microglia.
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What are the assessment scales for restless legs syndrome?
Time of Update: 2021-04-24
The subjective scale assessment of RLS includes assessment of the severity of symptoms, quality of life, and severity of symptoms.
The classification and scoring methods of the RLS evaluation scale are shown in Table 1.
Table 1 Classification and scoring method of restless legs syndrome (RLS) assessment scale.
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Blood pressure management for patients with acute ischemic stroke and heart disease, 3 minutes to focus
Time of Update: 2021-04-24
➤Recommendations for acute ischemic stroke combined with chronic heart failure: The average arterial pressure can be reduced by 15% from the baseline level within the first 24 hours after AIS; the blood pressure can be gradually controlled to a level that the patient's heart function can tolerate according to the cerebral perfusion status.
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[New research] The innate screams of human beings convey at least six emotions and play a role that cannot be ignored
Time of Update: 2021-04-23
On April 13, 2021, researchers from the University of Zurich published a new study in "PLOS Biology" entitled "Neurocognitive processing efficiency for discriminating human non-alarm rather than alarm scream calls".
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Cell | Acetylated Tau protein is a new target for traumatic brain injury
Time of Update: 2021-04-23
As another downstream mechanism of GAPDH sulfhydryl nitrosylation, the researchers used WldS mice to also reveal that the increase in Sirt1 activity can prevent brain injury-induced Tau protein acetylation, neurodegeneration, and behavioral disorders.
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Prevent stroke?
Time of Update: 2021-04-23
The results showed that compared with ICH patients, AIS patients had higher levels of RBP-4, NT-proBNP and endostatin, and lower levels of GFAP.
In summary, biomarkers including RBP-4, NT-proBNP, and GFAP have a specificity of 100% for the diagnosis of ischemic stroke and a certain sensitivity.
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Science Sub-Journal | Breakthrough, the team from Tianjin Medical University Liu Qiang found that the hope of improving the prognosis of acute brain injury is actually this group of cells...
Time of Update: 2021-04-23
Combining technologies such as micro-PET imaging, gene coding, and lineage tracing, the team further discovered that the body is innervated by nerves after cerebral hemorrhage, causing the bone marrow to produce monocytes with immune regulation functions in a short time.
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Cell: Who said that pressure is motivation?
Time of Update: 2021-04-23
The study showed that stress-induced hormones (glucocorticoids) can weaken the anti-cancer ability of innate-like T cells, leading to accelerated development and spread of cancer cells.
However, this study by Cell Reports shows that congenital T cells do not actually die due to chronic stress, but their anti-cancer ability is greatly impaired by stress-induced hormones (glucocorticoids).