Successfully cultivated the "mini brain" synchronized with the baby's brain development

Recently, in a new study published in "Nature Neuroscience", a research team from the University of California, Los Angeles (UCLA) and Stanford University found that humanbioon.
com/course_video/gan-xi-bao-zhi-liao-ji-qi-gui-fan-hua678956.
html">bioon.
com/tags/%E5%B9%B2%E7%BB%86%E8%83%9E/">The maturation of the three-dimensional "mini brain" organoids derived from bioon.
com/tags/%E5%B9%B2%E7%BB%86%E8%83%9E/">stem cells is surprisingly similar to the development of the human brain.

Dr.
Daniel Geschwind of UCLA and Dr.
Sergiu Pasca of Stanford University conducted extensive bioon.
com/course_video/zhong-guo-ren-qun-ying-yang-he-yi-chuan-yin416058.
html">genetic analysis on organoids cultured in a laboratory dish for 20 months .
They discovered that these three-dimensional structural organs follow an internal clock that guides their maturity in sync with the time of human development.

Dr.
Geschwind said: "This is a novel discovery, because so far, no one has been able to cultivate these organoids in such a long period of time, and no one has proven that they can reproduce most of the human brain in a laboratory environment.
These research results are an important impetus to the development process of humans.
We have shown that these organoids can mature and replicate many aspects of normal human development, which makes them a good model for studying human diseases in a petri dish.
"

Brain organoids using induced pluripotent bioon.
com/tags/%E5%B9%B2%E7%BB%86%E8%83%9E/">stem cells (also referred to as iPS cells) is created, the bioon.
com/tags/%E5%B9%B2%E7%BB%86%E8%83%9E/">stem cells derived from skin or blood cells, these cells or blood cells back to the embryonic reprogrammed bioon.
com/course_video/gan-xi-bao-zhi-liao-ji-qi-gui-fan-hua678956.
html">stem cell -like state, so that scientists can create any cell type .
Then, these bioon.
com/stemcell/">ips cells are exposed to a special chemical mixture that affects them, thereby generating cells in specific areas of the brain.
Under the right time and conditions, cells will self-organize to create a three-dimensional structure and "faithfully" replicate many aspects of human brain development.

Organoids derived from human bioon.
com/course_video/gan-xi-bao-zhi-liao-ji-qi-gui-fan-hua678956.
html">stem cells have the potential to revolutionize medical practice because it gives researchers an unprecedented understanding of how complex organs, including the brain, develop and how humans respond to diseases.

For many years, researchers have been cultivating human brain organs to study diseases caused by human nerves and neurodevelopmental disorders, such as epilepsy, autism, and schizophrenia.
Because of the general belief that the cells that make up these organoids remain in a developmental state similar to those seen in fetal development, the practicality of these models is hindered.

This new study shows that it is possible to grow these cells to a mature state.
This will allow scientists to better study adult diseases such as schizophrenia or dementia.
Geschwind added: "This work represents an important milestone.
It shows which aspects of human brain development are modeled with the highest fidelity, which specific genes perform well in vitro, and when they are best modeled.
Likewise.
Importantly, we provide a framework based on unbiased genomic analysis to evaluate the ability of in vitro models to simulate in vivo development and function.
"

Aaron Gordon, a postdoctoral researcher in Geschwind's laboratory, the first author of the study, said: "We discovered that these three-dimensional brain organoids follow an internal clock, and the progress of this clock in the laboratory environment is synchronized with what is happening in the human body.
This is An amazing discovery, we proved that they reached postpartum maturity about 280 days after culture, and then began to simulate all aspects of the infant’s brain, including known physiological changes in neurotransmitter signals.
"

In addition, the team also provides a tool called GECO that allows researchers to browse the genes of interest to measure the fidelity between the brain in vitro and in vivo.
(bioon.
com">Bioon.
com)

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