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Alzherimer's&Dementia | The physical examination reports are all brain atrophy, but the outcome is very different!
Time of Update: 2021-05-21
In the entire analysis sample and Aβ-positive participants, typical/diffuse brain atrophy was associated with faster Cognitive decline is related,Specifically, the incidence of dementia varies by atrophy subtype.
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Brain Stimul: External stimulation of the trigeminal nerve is a safe and effective treatment for focal drug-resistant epilepsy
Time of Update: 2021-05-21
Recently, researchers conducted a randomized trial to determine the long-term efficacy and tolerability of ETNS in patients with focal DRE, and to explore whether its efficacy depends on the epileptogenic area (frontal or temporal lobe) and its effects.
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Circulation: The relationship between preterm birth and long-term risk of stroke in women
Time of Update: 2021-05-21
However, it is unclear whether the long-term risk of stroke associated with preterm birth and whether such risks can be attributed to family confounding factors.
Preterm Delivery and Long-Term Risk of Stroke in Women A National Cohort and Cosibling Study .
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Nature Communications: Research confirms for the first time the diversity of various neurons that govern movement
Time of Update: 2021-05-21
Recently, in a study published in Nature Communications, researchers discovered a targeted single-nuclear RNA sequencing method and used it to identify cholinergic interneurons, visceral motor neurons, and skeletal motor neurons.
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J Nutr: Supplementing fish oil and curcumin can improve the cognitive ability of overweight or obese middle-aged and elderly people
Time of Update: 2021-05-21
gov/33097947/" target="_blank" rel="noopener">Evaluation of Cognitive Performance following Fish-Oil and Curcumin Supplementation in Middle-Aged and Older Adults with Overweight or Obesity .
gov/33097947/" target="_blank" rel="noopener">Evaluation of Cognitive Performance following Fish-Oil and Curcumin Supplementation in Middle-Aged and Older Adults with Overweight or Obesity in this message
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Pediatrics: Neonatal epilepsy, phenobarbital is not effective, try Levetiracetam
Time of Update: 2021-05-21
Recently, researchers conducted a multicenter, randomized, blinded, controlled phase IIb trial to explore levetiracetam The effectiveness and safety of phenobarbital as a first-line treatment for neonatal epileptic seizures, the results of the study have been published in Pediatrics.
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Alzheimer's disease has very different symptoms?
Time of Update: 2021-05-21
In recent years, with the help of advanced PET medical imaging technology, researchers have been able to monitor the accumulation of toxic proteins in the brains of patients with Alzheimer's disease.
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FDA issues guidelines for non-clinical research on personalized antisense oligonucleotide therapeutics
Time of Update: 2021-05-10
S. FDA issued on April 26 the draft guidelines for "Non-clinical Testing of Individualized Antisense Oligonucleotide Therapeutics for Severe Debilitating or Life-threatening Diseases", introducing support for research on individualized antisense oligonucleotides Non-clinical information recommended by the FDA for the Sexual New Drug Application (IND).
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Express | Subcutaneous RNAi Therapy Reached All Phase 3 Clinical Endpoints, New Drug Application Has Been Submitted
Time of Update: 2021-05-10
▎The content team editor of WuXi AppTec today, Alnylam Pharmaceuticals announced that the subcutaneous RNAi therapy vutrisiran developed by the company has reached the primary end point and all the secondary clinical trials in a phase 3 clinical trial for the treatment of patients with hereditary transthyretin (hATTR) amyloidosis.
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Cell: The next generation of gene editing technology CRISPRoff opens the surface...
Time of Update: 2021-05-10
On April 9, in a paper published in Cell, researchers from the University of California, San Francisco and Massachusetts Institute of Technology developed a new type of epigenetic genome editing tool "CRISPRoff".
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Can perfusion imaging predict infarct volume?
Time of Update: 2021-05-10
In order to evaluate the accuracy of perfusion weighted imaging (PWI) in predicting the infarct volume in patients with anterior circulation and great vessel occlusion 24 hours after the onset.
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Hausen's smoking cessation drug "Varenicline tartrate tablets" was approved for listing
Time of Update: 2021-05-10
The results of the study showed that varenicline does not increase the risk of negative neuropsychiatric events for smokers who have no history of mental disorders, and that varenicline is significantly more effective than nicotine transdermal patches and bupropion.
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Roche's new anti-influenza drug Xofluza will soon be approved in China
Time of Update: 2021-05-10
On April 25, the NMPA official website showed that the review status of Roche’s new anti-influenza drug Mabaloxavir Tablets (Xofluza) (acceptance number JXHS2000074/75) was changed to "under approval", which means that this new mechanism of action Innovative anti-influenza drugs are not far from being launched in China.
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Before reperfusion, lower blood pressure will increase the risk of infarct progression and poor prognosis?
Time of Update: 2021-05-10
The decrease in blood pressure (BP) during endovascular therapy (EVT) is associated with infarct progression and poor prognosis after large vessel occlusive (LVO) stroke.
The results of a recent study further proved that lower blood pressure before reperfusion may accelerate the risk of infarction progression and poor functional prognosis.
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AstraZeneca Selumetinib and Tagrisso were promoted by the European Union...
Time of Update: 2021-05-10
On the same day, AstraZeneca also announced that Tagrisso (osimertinib) has also been recommended for marketing in the European Union for the adjuvant treatment of early (IB, II and IIIA) epidermal growth factor receptor mutations (EGFRm) non-small cell lung cancer (NSCLC) adults Patients, these patients still have treatment intentions after the tumor is completely removed.
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The 3rd Attention Deficit Hyperactivity Disorder Care Week and Adolescent Mental Health Guardian Program...
Time of Update: 2021-05-10
Guo Meijian, Secretary of the Party Committee and Chairman of the China Youth Development Foundation, introduced: “During the second Attention Deficit Hyperactivity Disorder Care Week last year, we launched the “Youth Mental Health Campus” project to provide psychological counseling and psychological counseling to children across the country.
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Cell Stem Cell | Continuous progress!
Time of Update: 2021-05-09
Cumulative evidence based on single-cell transcriptomics analysis revealed the transcriptional heterogeneity of cortical neural progenitor cells, their temporal patterns, and the differentiation trajectory of excitatory neurons and inhibitory interneurons in the developing mammalian neocortex.
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Indifferent talk | talk about the indifference of Parkinson's disease patients
Time of Update: 2021-05-09
According to the neurology guidelines/expert consensus, apathy refers to a state of reduced motivation, which is clinically manifested as a decrease in goal-oriented behavior and a decrease in different degrees of interest and emotion, and it is not due to a decline in consciousness, nor is it a cognitive impairment or Caused by mood disorders [1].
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The staged diagnosis and intervention measures of Alzheimer's disease are absolutely dry!
Time of Update: 2021-05-09
According to the "2018 Chinese Guidelines for the Diagnosis and Treatment of Dementia and Cognitive Impairment (6): Pre-Dementia in Alzheimer's Disease", the NIA-AA standard recommends more detailed staging and description of the preclinical stage, including the normal group and SNAP The group (suspected non-AD group) is more suitable for the development of pre-clinical AD research.
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Sudden dizziness and nystagmus, the course of the disease was twists and turns, the cause was unexpected by the director
Time of Update: 2021-05-09
The patient developed bilateral peripheral facial paralysis soon after the onset of dizziness, weakened tendon reflexes, separated cerebrospinal fluid protein cells, and positive serum peripheral neuropathy series antibodies, all supporting GBS.
