-
Neurology: Multi-diffusion imaging model can be used to evaluate the white matter characterization of cerebral small vessel disease
Time of Update: 2021-06-29
The journal Neurology tested the hypothesis that the multiple diffusion model improves the characteristics of microstructural changes in cerebral small vessel disease (SVD), and evaluated the correlation between processing speed, longitudinal changes and the repeatability of diffusion indicators .
-
Alzheimer & Demetia: How to better identify the mood disorders of patients with Alzheimer's disease?
Time of Update: 2021-06-29
Examples of the latter method include the Cohen-Mansfield Agitation Inventory (CMAI) and the Neuropsychiatric Inventory (NPI), which are the most widely used measures in the trial .
The Cohen-Mansfield Irritability Scale (CMAI) and the Neuropsychiatric Disorder Scale (NPI) are the most widely used measures in the trial .
-
Neurology: Half of people with head injuries have varying degrees of disability
Time of Update: 2021-06-29
The 2011-2014 National Health and Nutrition Examination Survey (NHANES) provides a unique opportunity to estimate the prevalence of head injuries associated with loss of consciousness, which can be extended to the non-hospitalized civilian population of the United States 40 years of age or older .
-
Neurology: Academician Gu Dongfeng and Fuwai Hospital found that polygenic risk score can reflect the prognosis of stroke
Time of Update: 2021-06-29
In this way, Xiangfeng Lu of Fuwai Hospital constructed a comprehensive PRS (metaPRS) for stroke through large-scale GWAS summary statistics of East Asian ancestry, and then verified its use in stroke risk stratification and primary prevention in a large prospective population cohort.
-
Today's "Science" highlights: confirmed!
Time of Update: 2021-06-29
Some past studies have found that the difference in the "microstructure" of the white matter of the brain may be related to ADHD, depression, schizophrenia, and Alzheimer's disease .
-
Neurology: White matter lesions are related to behavioral performance after brain trauma in adolescents and children
Time of Update: 2021-06-29
These studies also reported a significant, moderate to high correlation between symptoms and WM tissue reduction, such as increased severity of white matter destruction predicting poor behavior in young TBI patients .
-
Neurology-Aortic stiffness may suggest neuroinflammation and neurodegeneration
Time of Update: 2021-06-29
The aortic pulse wave velocity was related to the concentration of CSF Aβ, p-tau, t-tau, neurogranin, NFL, YKL-40 and sTREM2 through linear regression, and adjusted for age, race/ethnicity, education, lipoprotein ( APOE) ε4 status, Framingham stroke risk profile and cognitive diagnosis .
-
Neurology: The higher the fasting blood sugar level, the more likely it is to have a stroke, but there are differences between men and women
Time of Update: 2021-06-29
Diagnose strokeAlthough little is known about the relationship between diabetes and stroke, data from the Causes of Stroke Geographic and Ethnic Differences (REGARDS) study showed that among white participants, the risk of stroke associated with diabetes varies by gender, but black Not so .
-
Translational Psychiatry: Ibudilast reduces alcohol and alcohol-induced nerve activation
Time of Update: 2021-06-29
Recently, Translational Psychiatry magazine reported an experimental drug trial that tested the efficacy of ibudilast in improving negative emotions, reducing alcoholism and weakening neural reward signals in AUD individuals .
-
Neurology: Dilation of the perivascular space is a biomarker for small vessel disease
Time of Update: 2021-06-29
Blood vesselThe journal Neurology published research papers on the measurement of EPVS and SVD and AD in CSO, BG and HP (including clinical diagnosis , disease-related biological The relationship between markers and cognitive measures) .
-
JNNP: ChAdOx1-nCoV-19 vaccine induced immune thrombotic thrombocytopenia manifested by ischemic stroke
Time of Update: 2021-06-29
Young patients with ischemic stroke after receiving ChAdOx1-nCoV-19 vaccine should immediately evaluate VITT through laboratory tests (including platelet count, D-dimer, fibrinogen, and anti-PF4 antibodies), and evaluate whether there are concurrent veins thrombosis; they should be by a multidisciplinary team (hematology, neurology, stroke, neurosurgery and neuroradiology) management , for quick access to treatment, including intravenous immunoglobulin, methylprednisolone, and non-plasma exchange Heparin anticoagulants, such as Fondaparinux, Argatroban, or direct oral anticoagulants .
-
JNNP: Intravenous immunoglobulin for mild Guillain-Barr syndrome: an international observational study
Time of Update: 2021-06-29
Prospectively collected data on age, gender, reported past events, and the following clinical characteristics: cranial nerve involvement, sensory impairment, MRC total score, ataxia, GBS disability score, GBS clinical variants, and autonomic dysfunction .
-
Brain: Microglia activation and blood-brain barrier permeability in cerebral small vessel disease
Time of Update: 2021-06-29
The hot spots of normal white matter and the average volume of blood-brain barrier permeability values of the sporadic SVD group were all related to dimension 1 (β=0.
-
"Step-Zhiyuan Research Cloud Academy" has started!
Time of Update: 2021-06-29
Come and listen to our live class!The important thing is said three times!
free!The important thing is said three times!
The important thing is said three times!
class schedule:Course Arrangement: Course Arrangement:purpose:Purpose: Purpose:Improve the scientific research thinking and ability of young and middle-aged physicians .
-
JAHA: The burden of ischemic stroke in patients with congenital heart disease
Time of Update: 2021-06-29
Compared with the control group without congenital heart disease (CHD), CHD patients have an increased risk of ischemic stroke (IS) .
However, the risk of stroke recurrence and all-cause mortality in CHD patients were 34% and 47% lower than those in the control group, respectively .
-
"Nature" sub-issue: Omega-3 fatty acids may help reduce depression
Time of Update: 2021-06-29
In summary, the study confirmed and expanded the evidence on the antidepressant, anti-inflammatory, and neuroprotective capabilities of EPA and DHA , and determined LOX-derived 5-HEPE and 4-HDHA and CYP450-derived 18-HEPE, 20-HDHA, 17( 18)-EpETE and 19(20)-EpDPA are the mediators of the effect of omega-3 PUFAs, further confirming that these metabolites are increased in the plasma of patients receiving EPA or DHA for depression (while depressive symptoms are improved) .
-
JAMA Psychiatry: Should marijuana be legalized?
Time of Update: 2021-06-29
In summary, the results indicate that the use of cannabis in mid-to-late adolescence may be related to changes in cortical development, especially in the prefrontal areas that are rich in CB1 receptors and exhibit long-term maturation trajectories .
-
Neurology: Elderly people with type 1 diabetes have a higher risk of dementia
Time of Update: 2021-06-29
For elderly people with type 1 diabetes, severe hypoglycemia and hyperglycemia events are associated with an increased risk of dementia in the future .
For elderly people with type 1 diabetes, severe hypoglycemia and hyperglycemia events are associated with an increased risk of dementia in the future .
-
Stroke: Stroke risk in premature adults
Time of Update: 2021-06-29
In this large national cohort, preterm birth was associated with an increased risk of hemorrhagic and ischemic stroke in adulthood .
Stroke Risks in Adult Survivors of Preterm Birth: National Cohort and Cosibling Study .
-
Human Brain Mapping: Reproductive history is related to the age of white matter in middle-aged and elderly women
Time of Update: 2021-06-29
The results showed that there was a negative correlation between birth history and white matter brain age, which may indicate that childbirth has a protective effect on white matter in future life .
