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JNNP: ChAdOx1-nCoV-19 vaccine induced immune thrombotic thrombocytopenia manifested by ischemic stroke

 Last Update: 2021-06-29
 Source: Internet
 Author: User

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ChAdOx1 nCoV-19 encoding SARS-CoV-2.

Immune Thrombosis Here, this article reports three VITT patients with ischemic stroke

Patient 1, a 35-year-old Asian female, a few days after receiving the ChAdOx1-nCoV-19 vaccine, was accompanied by paroxysmal right temporal and periorbital headaches

Blood vessel

Patient magnetic resonance imaging

Patient 2 is a 37-year-old white female who developed diffuse headache, loss of left visual field, confusion, and left arm weakness 12 days after the ChAdOx1 nCoV-19 vaccine

Patient 3, a 43-year-old Asian male, developed a language barrier 21 days after the ChAdOx1 nCoV-19 vaccine

The results of the study showed that in addition to venous thrombosis, the neurological symptoms of VITT also include arterial occlusion

The results of the study showed that in addition to venous thrombosis, the neurological symptoms of VITT also include arterial occlusion
.
Young patients with ischemic stroke after receiving ChAdOx1-nCoV-19 vaccine should immediately evaluate VITT through laboratory tests (including platelet count, D-dimer, fibrinogen, and anti-PF4 antibodies), and evaluate whether there are concurrent veins thrombosis; they should be by a multidisciplinary team (hematology, neurology, stroke, neurosurgery and neuroradiology) management , for quick access to treatment, including intravenous immunoglobulin, methylprednisolone, and non-plasma exchange Heparin anticoagulants, such as Fondaparinux, Argatroban, or direct oral anticoagulants
.
Manage Al-MayhaniT ,SaberS ,StubbsMJ Al-MayhaniT Al-Mayhani Saber S Saber Stubbs MJ Stubbs , et al Ischaemic stroke as a presenting feature of ChAdOx1 nCoV-19 vaccine-induced immune thrombotic thrombotic thrombocytopenia Journal of Neurology, Neurosurgery & Psychiatry Published Online First: 25 May 2021.
Published Online First: doi: 10.
1136/jnnp-2021-326984 doi:

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