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Age-related arterial rigidity (arterial stiffening), usually assessed using pulse wave velocity (pulse wave velocity), and cognitive impairment, brain structure and changes in cerebral small blood vessel disease
Blood vessel
Since elastic arteries, such as the aorta, harden with age, they are less able to cushion the normal changes in blood pulsation
Previous studies have investigated the link between vascular stiffness and the core pathology of Alzheimer's disease (AD), namely amyloid-β (Ab) and phosphorylated tau (p-tau)
In addition, in view of the activation of microglia and astrocytes after capillary injury, the increase in blood pulsation may lead to a cascade of neuroinflammation
However, the relationship between the slight increase in age-related aortic stiffness and the accompanying injury pathway remains unknown
Among participants over 73 years of age, higher aortic pulse wave velocity was associated with higher p-tau (β=2.
Aortic pulse wave velocity has a moderate interaction with the effect of diagnosis on neurogranin (β=-10.
The main significance of this study is that the oldest participants (>74 years old) found greater in vivo biomarker evidence of aortic stiffness and neuroinflammation, tau phosphorylation, synaptic dysfunction, and neurodegeneration.
Central arterial rigidity may lead to accumulated brain microcirculation damage and blood flow to tissues, leading to neuroinflammation and neurodegeneration at a higher age
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