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Low blood sugar disease and hyperglycemia is type 1 diabetes (T1D) patients with serious complications
.
Severe hypoglycemia refers to the loss of consciousness or self- management ability caused by hypoglycemia
Hypoglycemic diabetes management
Among adults with T1D, it is estimated that the annual incidence of severe (emergency room or hospitalization) hypoglycemia is about 12%, and the annual incidence of severe (emergency room or hospitalization) hyperglycemia is about 5 %
.
Both forms of serious blood glucose events are diabetic emergencies, and both can be avoided
With the recent progress in diabetes treatment, patients with T1D live longer than before
.
This extended life span puts them at risk of aging-related diseases, such as dementia
Blood sugar control has become a potentially modifiable factor related to cognition and dementia, which indicates a preventive goal for future brain health
Vascular assessment is very important to assess whether such events in elderly T1D patients will put them at a higher risk of dementia in the future
They tracked 2,821 type 1 diabetes patients in a comprehensive medical service system from 1997 to 2015
.
The medical records from January 1, 1996 onwards extracted hypoglycemia and hyperglycemia events that required emergency or hospitalization until the queue entered
Type 1 diabetes
Participants were tracked and diagnosed with dementia before September 30, 2015
.
Use the Cox proportional hazard model to adjust for age (as a time scale), gender, race/ethnicity, HbA1c, depression, stroke, and kidney disease to study the risk of dementia
diagnosis
They found that of 2,821 elderly people with type 1 diabetes (average age 56 years), 398 (14%) had a history of severe hypoglycemia, 335 (12%) had a history of severe hyperglycemia, and 87 (3 %) Both
.
During an average follow-up of 6.
In the fully adjusted model, people with hypoglycemic events have a 66% greater risk of dementia than people without hypoglycemia (HR=1.
66; 95%CI: 1.
09, 2.
53), while people with hyperglycemia are more likely to develop dementia than those without hypoglycemia (HR=1.
66; 95%CI: 1.
09, 2.
53).
People who did not have a hyperglycemia event were at risk more than twice (HR=2.
11; 95%CI: 1.
24, 3.
59)
.
Compared with people without hypoglycemia, people with severe hypoglycemia and hyperglycemia have a 6 times greater risk of dementia (HR=6.
20; 95%CI: 3.
02, 12.
70)
.
The important significance of this study lies in the discovery: For elderly people with type 1 diabetes, severe hypoglycemia and hyperglycemia events are associated with an increased risk of dementia in the future
.
.
For elderly people with type 1 diabetes, severe hypoglycemia and hyperglycemia events are associated with an increased risk of dementia in the future
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