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Cerebral Cortex: Differences in hemispheric lateralization associated with autism spectrum disorder exist in infancy
Time of Update: 2022-08-12
Comparing children with ASD (n = 301) and TD (n = 432) in terms of functional connectivity in four brain regions, posterior cingulate cortex (PCC), posterior superior temporal gyrus, extrastriatal cortex, and prefrontal cortex showed differences between groups .
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npj Parkinsons Dis: Thalamic white matter macrostructure and subnuclear volume are strongly associated with depression in Parkinson's disease
Time of Update: 2022-08-12
Right PuA is a relevant neural structure in PD depression, and future work should assess its potential as a therapeutic target for PD depression Original source: Bhome R, Zarkali A, Thomas GEC, Iglesias JE, Cole JH, Weil RS.
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Another benefit of "good cholesterol"!
Time of Update: 2022-08-12
To analyze the association between higher levels of "good cholesterol" particles in cerebrospinal fluid and lower AD risk, Keck School of Medicine researchers recruited 180 healthy participants over the age of 60 and compared their plasma and cerebrospinal fluid samples were analyzed .
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NEUROLOGY: Stroke and lacunar counts on MRI are independent predictors of vascular cognitive impairment
Time of Update: 2022-08-12
Logistic regression analysis of the effects of MRI parameters on BMET VCI and MoCA VCI in CADASIL patients while controlling for age and gender Table 4.
Logistic regression analysis of the effects of MRI parameters on BMET VCI and MoCA VCI in CADASIL patients while controlling for age and gender Table 4.
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How should flunarizine be used?
Time of Update: 2022-08-12
Especially for basilar artery and internal carotid artery, improve brain microcirculation and neuron metabolism, can increase blood flow of cochlear arteriole, improve vestibular organ circulation, prevent nerve cell paroxysmal depolarization and cell discharge, and have anti-epileptic effect It can also significantly reduce ischemic myocardial damage, protect myocardial cells, has high lipid solubility, and easily penetrate the blood-brain barrier.
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Science: Heavy!
Time of Update: 2022-08-12
. On May 26, 2022, Science magazine published an article online by Arkady Khoutorsky's research team from McGill University in Canada in the form of a first release, finding that peripheral nerve injury caused a large number of PNNs in the spinal cord to degrade and cause pain behavior, which is mediated by microglia.
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Neurology: Association of neurofilament light with the development and severity of Parkinson's disease
Time of Update: 2022-08-12
We examined the association between baseline serum neurofilament light and changes in Parkinson's symptoms and physical function over 16 years in patients with clinically diagnosed Parkinson's disease in an elderly-based population sample .
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Neurology: Aneurysmal subarachnoid hemorrhage in those with short reproductive years and early menopause
Time of Update: 2022-08-12
Multivariate analysis of the association between early menopause and late menarche and aneurysmal subarachnoid hemorrhageTaken together, earlier age at menopause and shorter reproductive years (≤35 years) were associated with a higher risk of developing aSAH in women, supporting a role for estrogen in the pathogenesis of aSAH .
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One earth: What makes you sleep less than 44 hours a year?
Time of Update: 2022-08-12
In a study titled "Rising temperatures erode human sleep globally" (Figure 1), published in One Earth on May 20, researchers used air temperature models to find that warmer nighttime temperatures reduce humans by an average of 44 hours per year.
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JNNP: Serum GFAP differentiates Alzheimer's disease from frontotemporal dementia and predicts the transition from MCI to dementia
Time of Update: 2022-08-12
This suggests that the differences in reactive astrogliosis between AD and bvFTD have pathophysiological implications and may also be of diagnostic relevance, as differential diagnosis to date has been largely based on clinical symptoms and cerebrospinal fluid biomarkersThe purpose of this study was to evaluate and compare changes in blood GFAP levels in more than 600 patients with AD and bvFTD .
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Mol Psychiatry: Peripheral inflammation can also enter the brain!
Time of Update: 2022-08-12
. Using data from 361,653 participants in the UK Biobank (UKB), longitudinal associations between dementia events and peripheral immune markers, including immune cell counts and their derived ratios, including the neutrophil-to-lymphocyte ratio (NLR), were investigated ), platelet-to-lymphocyte ratio (PLR), systemic immune inflammation index (SII), and lymphocyte-to-monocyte ratio (LMR) .
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JNNP: Etiology, secondary prevention strategies and prognosis of ischemic stroke in patients with atrial fibrillation after oral anticoagulation therapy
Time of Update: 2022-08-12
1136/jnnp-2021-328391doi: leave a message here Direct oral anticoagulants (DOACs) or vitamin K antagonists (VKAs) reduce ischemic stroke risk in patients with nonvalvular atrial fibrillation (AF) .
1136/jnnp-2021-328391doi: leave a message here Direct oral anticoagulants (DOACs) or vitamin K antagonists (VKAs) reduce ischemic stroke risk in patients with nonvalvular atrial fibrillation (AF) .
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Front. Aging Neurosci: Alzheimer's disease-related markers associated with physical activity levels in cognitively normal older adults
Time of Update: 2022-08-12
Aging Neurosci to evaluate the relationship between habitual physical activity levels and brain amyloid deposition and AD -related blood biomarkers in (APOE) ε4 carriers and non-carriers .
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Neurology: Snoring is a disease, positive pressure ventilation is a good choice
Time of Update: 2022-08-12
Since there are no effective treatments to prevent , cure or delay the progression of dementia, identifying treatable risk factors that increase the risk of dementia, such as obstructive sleep apnea (OSA), can provide insights into changing the occurrence or severity of dementia promising means .
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Biol Psychiatry︱Huang Zhuo's group reveals the important role of JADE2 in hippocampal synaptic plasticity and learning and memory
Time of Update: 2022-08-12
, Biol Psychiatry, 2022) Conclusion and discussion, inspiration and prospect Experiments in molecular biology and animal behavior have found that the epigenetic factor JADE2 is crucial in the regulation of structural plasticity and memory formation Figure 5 JADE2 regulates learning and memory ability through the expression of RAC1 (Source: Fan M, Liu Y, et al.
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BMJ: These healthy lifestyles can prolong life by 5 years and prevent Alzheimer's disease
Time of Update: 2022-08-12
Paper link: Paper link: https:// Leave a message here The study showed that people aged 65 and over who had a healthy life>a healthy life> and a healthy life>The brain remains sharp, significantly reducing the risk of Alzheimer's disease .
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Stroke: Young people with sickle cell anemia have no increased risk of occult cerebral infarction
Time of Update: 2022-08-12
Blood vesselAs a case-control study, brain magnetic resonance imaging was performed in young adults with SCT (N=25, cases) and those without SCT (N=24, controls) to quantify brain volume, microstructural integrity (anisotropy), silent cerebral infarction (SCI), intracranial stenosis and aneurysm .
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European Radiology: How to apply DWI and ADC to improve the segmentation performance of deep learning models for acute ischemic stroke?
Time of Update: 2022-08-12
Recently, a study published in European Radiology examined the role of observer, ADC threshold and lesion size on the segmentation performance of DWI-based AIS deep learning models (DLMs) for rapid and accurate diagnosis and assessment of infarct area and treatment.
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More than 370,000 people followed up for 9 years: drinking tea to prevent dementia is true, and it can reduce the risk by 29%!
Time of Update: 2022-08-12
As for the different categories of tea consumption, participants who drank tea in moderation (1-6 cups/day) had a lower risk of dementia compared with non-tea drinkers, with the following results:There was a significant association between tea consumption and a reduced risk of developing dementia after controlling for age, gender and ethnicity (Model 1) .
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Positive results from phase III trial of long-acting C5 complement inhibitor Ultomiris in neuromyelitis optica
Time of Update: 2022-08-12
immunityAstraZeneca recently reported that Ultomiris (ravulizumab-cwvz) met the primary endpoint of a Phase III study (CHAMPION-NMOSD trial) testing a long-acting C5 complement inhibitor in patients with neuromyelitis optica spectrum disorder (NMOSD) Ultomiris .
