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JNNP: Etiology, secondary prevention strategies and prognosis of ischemic stroke in patients with atrial fibrillation after oral anticoagulation therapy

 Last Update: 2022-08-12
 Source: Internet
 Author: User

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Direct oral anticoagulants (DOACs) or vitamin K antagonists (VKAs) reduce ischemic stroke risk in patients with nonvalvular atrial fibrillation (A.

Stroke Prevention Growing evidence suggests that patients with AF and stroke have a higher risk of future recurrence despite anticoagulation compared with patients who did not receive anticoagulation prior to their stro.

In fact, despite anticoagulation, the optimal treatment for stroke patients remains unclear, and the latestguidelines make no recommendation.

The article was published in the Journal of Neurology, Neurosurgery & Psychiatr.

We analyzed patients with atrial fibrillation who were consecutively treated with vitamin K antagonists (VKAs) or direct oral anticoagulants (DOACs) but had index imaging-confirmed ischemic stroke at 11 stroke cente.

Research flow chart

Of 2946 patients (median age, 81 years; 48% female; 43% VKA, 57% DOAC), 713 patients (24%) had a competing cause of stroke, and 934 patients (32%) had a Insufficient coagulation, 1299 patients (44%) experienced cardiac embolism despite adequate anticoagulati.

Of 2946 patients (median age, 81 years; 48% female; 43% VKA, 57% DOAC), 713 patients (24%) had a competing cause of stroke, and 934 patients (32%) had a Inadequate coagulation, 1299 patients (44%) despite adequate anticoagulation

Changes in oral anticoagulant therapy at index stroke (pre-stroke) and at discharge (post-stroke)

Despite anticoagulation in patients with atrial fibrillation, inadequate anticoagulation remains an important cause of stro.

PolymerisAA ,MeinelTR ,OehlerH PolymerisAAPolymeris MeinelTRMeinel OehlerHOehler, et alsecondary prevention strategies and outcomes of ischaemic stroke despite oral anticoagulant therapy in patients with atrial fibrillationJournal of Neurology, Neurosurgery & PsychiatryPublished Online First:08 April 202 Published Online First: doi:11136/jnnp-2021-328391doi:leave a message here

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