-
Stroke: The residual cholesterol variability of the LDL-C "backbone" is closely related to the occurrence of ischemic stroke!
Time of Update: 2022-08-12
strokeThe study was a post hoc analysis and included eligible participants from the Kailuan study cohort who underwent 3 health checkups between 2006 and 2010 and were free of atrial fibrillation, myocardial infarction , stroke, cancer, or known lipid profile quality drug use .
-
JAMA: Effects of early versus standard approach tracheostomy on functional recovery in severe stroke patients receiving mechanical ventilation
Time of Update: 2022-08-12
To test whether early tracheal intubation versus standard tracheal intubation can improve functional outcomes in stroke patients receiving mechanical ventilation, researchers from the University of Heidelberg, Germany conducted a randomized clinical trial involving 382 patients with severe acute ischemia receiving invasive ventilation.
-
More than 370,000 people followed up for 9 years: drinking tea to prevent dementia is true, and it can reduce the risk by 29%!
Time of Update: 2022-08-12
As for the different categories of tea consumption, participants who drank tea in moderation (1-6 cups/day) had a lower risk of dementia compared with non-tea drinkers, with the following results:There was a significant association between tea consumption and a reduced risk of developing dementia after controlling for age, gender and ethnicity (Model 1) .
-
European Radiology: How to apply DWI and ADC to improve the segmentation performance of deep learning models for acute ischemic stroke?
Time of Update: 2022-08-12
Recently, a study published in European Radiology examined the role of observer, ADC threshold and lesion size on the segmentation performance of DWI-based AIS deep learning models (DLMs) for rapid and accurate diagnosis and assessment of infarct area and treatment.
-
Stroke: Young people with sickle cell anemia have no increased risk of occult cerebral infarction
Time of Update: 2022-08-12
Blood vesselAs a case-control study, brain magnetic resonance imaging was performed in young adults with SCT (N=25, cases) and those without SCT (N=24, controls) to quantify brain volume, microstructural integrity (anisotropy), silent cerebral infarction (SCI), intracranial stenosis and aneurysm .
-
Biol Psychiatry︱Huang Zhuo's group reveals the important role of JADE2 in hippocampal synaptic plasticity and learning and memory
Time of Update: 2022-08-12
, Biol Psychiatry, 2022) Conclusion and discussion, inspiration and prospect Experiments in molecular biology and animal behavior have found that the epigenetic factor JADE2 is crucial in the regulation of structural plasticity and memory formation Figure 5 JADE2 regulates learning and memory ability through the expression of RAC1 (Source: Fan M, Liu Y, et al.
-
BMJ: These healthy lifestyles can prolong life by 5 years and prevent Alzheimer's disease
Time of Update: 2022-08-12
Paper link: Paper link: https:// Leave a message here The study showed that people aged 65 and over who had a healthy life>a healthy life> and a healthy life>The brain remains sharp, significantly reducing the risk of Alzheimer's disease .
-
Front Nutr: Cranberry intake may improve brain memory and help fight dementia
Time of Update: 2022-08-10
Aging is highly correlated with cognitive decline, and modifiable risk factors such as diet may be thought to protect the body against aging . Recently, an article was published in the international j
-
Neurology: Outcomes of persistent headache in adolescents with chronic migraine and their parents: a pilot survey study
Time of Update: 2022-08-10
. Adolescents and their parents diagnosed with ICHD-3 chronic migraine, persistent headache and treated in a tertiary pediatric headache clinic were investigated to question the value of treatment outcomes in headache frequency, intensity, functional impact, and related symptom domains .
-
Jiang Yi/Xu Huaqiang from Shanghai Institute of Materia Medica, Nature Sub-Journal Reveal the Molecular Mechanism of Neuromodulin NMU/NMS Selectively Recognizing Neuromodulin U Receptor
Time of Update: 2022-06-13
On April 19, 2022, the research team of Jiang Yi/Xu Huaqiang from Shanghai Institute of Materia Medica, Chinese Academy of Sciences published the research results entitled "Structural insights into the peptide selectivity and activation of human neuromedin U receptors" in Nature Communications .
-
If you encounter a patient with a ruptured intracranial aneurysm, knowing these 8 points can save your life
Time of Update: 2022-06-13
(2) For patients with good clinical condition and low disease grade (Hunt-Hess class I-III or WFNS class I-III), aneurysm clipping or interventional embolization should be performed as soon as possible to reduce the risk of rebleeding (class I).
-
Cell Death Dis︱Kong Hui et al reveal the role of P2X7/NLRP3 inflammasome pathway in early diabetic retinopathy
Time of Update: 2022-06-13
The team proposed that the P2X7/NLRP3 inflammasome pathway is involved in early diabetic retinopathy and plays a crucial role in the inflammation, apoptosis and pyroptosis of endothelial cells, which provides a direction for the study of the inflammatory mechanism of DR.
-
Aspirin, clopidogrel... Learn about 5 commonly used antiplatelet drugs in this article
Time of Update: 2022-06-13
Antiplatelet drugs are one of the main treatment drugs for ischemic cerebrovascular disease, which includes a wide variety of commonly used clinically aspirin, clopidogrel, ticagrelor, cilostazol, dipyridamole, etc.
Let's take a look at the mechanism of action, recommended dosage and precautions of these commonly used clinical antiplatelet drugs .
-
New developments in the field of Roche's rare neurological diseases
Time of Update: 2022-06-13
Efficac and Safety of Ocrelizumab in Patients With RRMS With Suboptimal Response to Prior Disease-Modifying Therapies: 3-Year Data From CASTING and LIBERTO (LIBER TO 1-Year Interim Results) (full text access) SUNFISH: risdiplam therapy 3-Year Efficacy and Safety of Type 2/3 SMA Risprom is an oral, survival motor neuron 2 (SMN2) splicing modifier approved by the FDA and CDE for the treatment of 2 months of age and older patients with spinal muscular atrophy (SMA) .
-
Neuron: It hurts to look at?
Time of Update: 2022-06-13
Through in vitro electrophysiological experiments, it was found that during empathic pain behavior, the excitatory postsynaptic currents of circuit neurons in bystander mice increased, the release of presynaptic glutamate increased, and pyramidal neurons in the IC projecting BLA brain regions and Excitatory inputs to interneurons are all increased .
-
How to save legs that have nowhere to go?
Time of Update: 2022-06-11
At present, the diagnosis is mainly based on the following four aspects: (1) The clinical manifestations conform to the characteristics of RLS symptoms and the diagnostic criteria of IRLSSG; (2) Periodic leg movements can be seen in PSG; (3) Complete abdominal examinations to exclude digestive system diseases; (4) Dopamine receptor agonist therapy is effective .
-
Headache after dural puncture—risks and current treatments
Time of Update: 2022-06-11
In another retrospective cohort study, 40 accidental dural punctures and 40 controls were assessed for symptoms of headache and back pain 12-24 months postpartum .
-
A new treatment option under the normalization of the epidemic--Ozamod treated patients can generate an effective immune response after being vaccinated against the new crown
Time of Update: 2022-06-11
Based on the drug mechanism and clinical studies with small sample size, the consensus pointed out that beta-interferon, teriflunomide, and dimethyl fumarate will not affect the effectiveness of the new crown vaccine, while receiving sphingosine-1-phosphate (S1P) Efficacy of vaccination in MS patients treated with body modulators (including fingolimod, siponimod) and anti-CD20 monoclonal antibodies (rituximab and its biosimilars, ofatumumab) may have declined .
-
Back-to-back Science Sub-Journal: Are foreign immune cells good for infection?
Time of Update: 2022-06-11
Orex-HA mice, a hypothalamic orexinergic neuron that selectively expresses the self-antigen hemagglutinin (HA), rapidly increased the number of CD8-positive T cells in the hypothalamic region following intravenous injection of HA-specific effector CD8-positive T cells The subsequent increase in expression of CD69 and CD103 was evident on day 8 post-injection, suggesting that CD8-positive T-RM cells reside in the hypothalamus .
-
The most detailed analysis of "Dizziness/vertigo assessment for the elderly", 8 steps!
Time of Update: 2022-06-11
In the clinic, we can make a preliminary diagnosis of dizziness/vertigo in the elderly through detailed medical history collection and physical examination.
Therefore, when dizziness/vertigo or walking instability occurs in the elderly, it is necessary to ask the patient about the medication history, especially the newly added medication .
