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Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) is the most common hereditary stroke
Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) is the most common hereditary stroke
University of Cambridge Amy A Jolly et al identified the pattern and prevalence of cognitive impairment in a large cohort of patients with CADAS.
The study used the Brief Memory and Executive Test (BMET) to assess cognitive performance in genetically confirmed CADASIL patients (n = 176) and healthy controls (n = 265) (mean (SD) age 595(135) v 537(93) year.
The study used the Brief Memory and Executive Test (BMET) to assess cognitive performance in genetically confirmed CADASIL patients (n = 176) and healthy controls (n = 265) (mean (SD) age 595(135) v 537(93) year.
The study found:
VCI was more common in CADASIL than controls; BMET score: 38% vs 12%; MOCA score: 47% vs 1
VCI was more common in CADASIL than controls; BMET score: 38% vs 12%; MOCA score: 47% vs 1
TableComparison of demographic and clinical characteristics of VCI patients and non-VCI patients in BMET and MoCA
After controlling for age and sex, history of stroke was associated with VCI for BMET (OR 12, 95% CI [05, 27] p = 04) and MoCA (OR 55 [21, 41] p = 0
After controlling for age and sex, history of stroke was associated with VCI for BMET (OR 12, 95% CI [05, 27] p = 04) and MoCA (OR 55 [21, 41] p = 0
Number of lacunae was the only MRI parameter independently associated with BMET VCI after controlling for other MRI parameters Number of lacunae was the only MRI parameter independently associated with BMET VCI (OR: 63, 95% CI [10, 41], p = 01
TableLogistic regression analysis of the effects of MRI parameters on BMET VCI and MoCA VCI in CADASIL patients while controlling for age and gender
Almost half of CADASIL patients with a mean age of 50 years have V.
Almost half of CADASIL patients with a mean age of 50 years have V.
original source
Prevalence and Predictors of Vascular Cognitive Impairment in Patients With CADAS.
Prevalence and Predictors of Vascular Cognitive Impairment in Patients With CADAS.
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