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Dementia is one of the leading causes of disability and dependence in older adults, as it affects memory, thinking, behavior and the ability to perform daily activiti.
Dementia is one of the leading causes of disability and dependence in older adults, as it affects memory, thinking, behavior and the ability to perform daily activiti.
The most common form of Alzheimer's disease (AD) usually begins after age 65 (late-onset A.
Inflammation is often the body's response to injury and stress, such as redness that accompanies injury or infection ; however, inflammation in the brain (neuroinflammation) is now thought to be directly related to a variety of diseases, such as depression , psychosis and multiple sclerosis, and recently researchers have found that neuroinflammation is directly related to the pathogenesis of Alzheimer's diseas.
The role of central immune components, especially microglia in dementia, has been fully studied, and corresponding immunotherapy has gradually attracted people's attenti.
The role of central immune components, especially microglia in dementia, has been fully studied, and corresponding immunotherapy has gradually attracted people's attenti.
Using data from 361,653 participants in the UK Biobank (UKB), longitudinal associations between dementia events and peripheral immune markers, including immune cell counts and their derived ratios, including the neutrophil-to-lymphocyte ratio (NLR), were investigated ), platelet-to-lymphocyte ratio (PLR), systemic immune inflammation index (SII), and lymphocyte-to-monocyte ratio (LM.
During a median follow-up of 99 years, 4239 participants developed dement.
Research points to different roles of innate and adaptive immunity in the pathogenesis of dementia, which may provide some new perspectives on the etiology and treatment of dement.
Research points to different roles of innate and adaptive immunity in the pathogenesis of dementia, which may provide some new perspectives on the etiology and treatment of dement.
references:
references:Peripheral immunity is associated with the risk of incident dement.
Peripheral immunity is associated with the risk of incident dement.
Mol Psychiat.
2022 Jan 2 Peripheral immunity is associated with the risk of incident dement.
Mol Psychiat.
2022 Jan 2 Peripheral immunity is associated with the risk of incident dement.
Mol Psychiat.
2022 Jan 2Leave a message here
