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Annals of Neurology : Blood-brain barrier disruption, AD and vascular disease are at high risk
Time of Update: 2022-10-02
In vivo studies have also shown that patients with cognitive impairment have higher concentrations of hematogenous albumin in the cerebrospinal fluid (CSF) compared to healthy control groups, indicating BBB disruption.
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Cases of obstructive hydrocephalus (midbrain duct stenosis).
Time of Update: 2022-10-02
Hydrocephalus (Hydrocephalus) is more common after various cranial trauma or intracranial masses, so that cerebrospinal fluid absorption disorders, circulatory obstruction or excessive secretion and c
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【Classic case analysis】Picture image diagnosis and analysis of MRI cases of chronic hepatic encephalopathy
Time of Update: 2022-10-02
【Diagnostic imaging】:Chronic hepatic encephalopathy【Diagnostic points】:【Clinical signs and symptoms】:【Differential diagnosis】: Picture image diagnostic analysis of MRI cases of chronic hepatic encephalopathy【Clinical history】: Patient, male, 54 years old, suffering from hepatitis C, the first symptoms are tremor and mental abnormalities.
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CT grade for acute pancreatitis
Time of Update: 2022-10-02
Grade E: Fluid accumulation in 2 or more of the multiple spaces around the pancreas, or gas shadows in the pancreatic parenchyma and fat gap around the pancreas, the formation of pancreatic parenchyma or peripancreatic abscess, and the significant decrease in hematuria amylase.
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Science: The function of microglia is being tapped again! Studies have revealed its involvement in the relief of neuropathic pain
Time of Update: 2022-10-02
Figure 1: Necessity of spinal cord CD11c+ microglia for spontaneous pain reliefCD11c+ microgliaSpontaneous pain relief is caused by IGF1To explore what molecules CD11c+ microglia play a role in, the researchers performed RNA sequencing of CD11chigh and CD11cneg microglia in the spinal cord after PNI, and the results showed that the expression of Igf1 in CD11chigh was significantly higher than that in CD11cneg.
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Imaging characteristics of progressive multifocal leukoencephalopathy Have you mastered them?
Time of Update: 2022-10-02
Key points of diagnostic imaging:single or multiple asymmetric white matter lesions characterized by low T1 and high T2 signals, with limited marginal diffusion visible, which supports the diagnosis of demyelinating lesions;Most lesions are in the pericerebral white matter and cortex, showing a fan-shaped U-fiber shape;Occasional cerebellar and brainstem involvement;Gray matter involvement is uncommon;The placeholder effect is not obvious;Occasionally with the edge of the lesion and scattered within the lesion punctate enhancement.
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Neurology: Synaptic and axonal integrity, with a huge impact on gray matter atrophy
Time of Update: 2022-10-02
The harmful effects of CSF AD protein abnormalities on the medial temporal lobe and total gray matter volume were detected only in people with high (more abnormal) levels of CSF synaptoprotein, even in clinically normal adults.
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Neurology: Physical activity increases total brain volume, gray matter density, and cortical thickness
Time of Update: 2022-10-02
References:Association Between Accelerometer-Derived Physical Activity Measurements and Brain Structure：A Population-Based Cohort Study While there is growing evidence that physical activity promotes neuronal health, the relationship between physical activity and brain morphology remains inconclusive.
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Obstructive hydrocephalus (midbrain aqueous tube stenosis)
Time of Update: 2022-10-02
Hydrocephalus (Hydrocephalus) is more common after various cranial trauma or intracranial masses, so that cerebrospinal fluid absorption disorders, circulatory obstruction or excessive secretion and c
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NatMed: marker for neurodegenerative diseases
Time of Update: 2022-10-02
3) Biomarkers for α-synuclein pathologyAlthough α-synuclein can be accurately detected in CSF, due to its low specificity, it cannot distinguish well between various neurodegenerative diseases and is not used much in clinical practice and trials.
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Redox Biology: Correlation between ROS and calcium ions in neurodegenerative diseases
Time of Update: 2022-10-02
On the one hand, calcium ions can produce a wide range of action by controlling membrane potential, regulating the production of ATP, and influencing proteins such as calmodulin or calmodulin; On the other hand, excessively high levels of calcium ions in mitochondria can also be effective in inducing and triggering cell death.
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Grasping the timing of epilepsy treatment in children is the key to reducing brain damage and avoiding brain development!
Time of Update: 2022-10-02
Seizures on children's cognitive function damage involves intelligence, language, comprehension and other aspects, if not timely treatment, as far as possible to reduce or eliminate the adverse effects of epilepsy on children, it is likely to affect children's brain development.
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Professor Ji Yong interviewed: Alzheimer's disease to achieve clinical early screening and early diagnosis, how far away is we
Time of Update: 2022-10-02
Based on current research, lesions in the human brain are quietly changing 15 to 20 years before the clinical manifestations of AD, so to achieve diagnostic and treatment interventions in the prime ti
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Causes and clinical features of stroke
Time of Update: 2022-10-02
➤ Cardiogenic stroke: 25% of ischemic strokes are caused by cardioembolism (mainly AF), the risk of which increases with age.
➤ Cardiogenic stroke: 25% of ischemic strokes are caused by cardioembolism (mainly AF), the risk of which increases with age.
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【Atlas】High-definition anatomical diagram of spinal cord, spinal cord and spinal nerve
Time of Update: 2022-10-02
Figure 1: Posterior view of the lumbar spineFigure 2: Intertransverse ligament, supraspinous ligament, iliac lumbar ligament (from the lumbar 5 transverse process, ending at the posterior inner lip of
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Neurology: Disease-associated α-synuclein aggregates as biomarkers for the clinical phase of Parkinson's disease
Time of Update: 2022-10-02
The main research question explored in this study is whether combining αSyn SAA and oligomer-specific ELISA provides accurate and robust measurable test readings that reflect disease severity in patients with PD.
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Reye syndrome – encephalopathy - fatty liver syndrome
Time of Update: 2022-10-02
It may also present with diffuse cortical and white matter changes, and in the acute phase manifest as a high cortical layered T2WI signal, which can be strengthened; Diffuse layered hypersignal in chronic phase T1WI; At the same time, white matter changes and brain atrophy Brief introductionReye syndrome is an acute mitochondrial injury manifested by acute encephalopathy, selective liver impairment, and infiltration of visceral fat, with clinical changes such as encephalopathy and biochemical changes as liver disease.
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Express Alnylam's Another RNAi Therapy Approved! Symptoms can be improved by quarterly injections
Time of Update: 2022-10-02
▲If you have any business needs, please long press to scan the QR code above, or▎Editor of WuXi AppTec content teamAlnylam Pharmaceuticals today announced the European Commission's (EC) approval of its RNAi therapy Amvuttra (vutrisiran), which can treat stage 1 and 2 polyneuropathy in adults with hereditary transthyroxine-mediated (hATTR) amyloidosis at a frequency of every 3 months.
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Does World Alzheimer's Day Whole Milk Accelerate Cognitive Decline in the Elderly?
Time of Update: 2022-10-02
Saturated fat hypothesisThe results showed that during the 2-year follow-up period, the high intake of whole milk in the elderly at high risk of cardiovascular disease was positively correlated with the incidence of cognitive impairment in the elderly with less milk intake.
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WIREs Anhui Medical University Wang Xianwen team nanotechnology in polymorphoblastoma: emerging treatment strategies
Time of Update: 2022-10-02
Therefore, nanodrugs can design multifunctional nano-sensitizers according to the proliferation and invasion mechanisms of different types of tumors, and the treatment methods combined with traditional radiotherapy and chemotherapy can maximize the effect of tumor eradication.
