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Neurology: low blood pressure, body mass index, non-HDL cholesterol and risk of dementia in later life
Time of Update: 2022-10-02
A recent study published in Neurology explored whether a combination of low values of low systolic blood pressure (SBP), body mass index (BMI), and non-HDL in later life was associated with a higher risk of dementia compared to the low values of these risk factors.
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Using scientific research to eradicate oblivion | a selection of papers on World Alzheimer's Day
Time of Update: 2022-10-02
September 21 is World Alzheimer's Day, and in order to raise public awareness of the disease and promote related research, we have selected Alzheimer's disease-related research papers from Cell, Neuron, Developmental Cell and Cell Reports from Cell Press's journal series, including chaperone-mediated autophagy Autophagy, CMA), Tau protein lesions and nucleoplasmic transport, microglia proliferation and β amyloid accumulation and other organic research, but also includes transcriptomics and genetic sequencing, 3D cell models, neurological disease imaging and other methodological applications and breakthroughs.
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Cell| a super-large family health-controlled paired study reveals a relationship between intestinal flora and multiple sclerosis
Time of Update: 2022-10-02
Through the analysis of microbiome, metabolome, diet, and clinical data of 576 MS-health controls (members in the family who are not related to the genetic background of MS patients), the study revealed the effects of disease risk, disease course, and related therapies on the intestinal flora of MS patients.
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Neurology: How does the sense of smell and cognitive motor risk relate
Time of Update: 2022-10-02
Impaired olfactory function may be associated with an increased risk of developing MCR.
Impaired olfactory function may be associated with an increased risk of developing MCR.
Impaired olfactory function may be associated with an increased risk of developing MCR.
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Neurology: Physical activity increases total brain volume, gray matter density, and cortical thickness
Time of Update: 2022-10-02
References:Association Between Accelerometer-Derived Physical Activity Measurements and Brain Structure：A Population-Based Cohort Study While there is growing evidence that physical activity promotes neuronal health, the relationship between physical activity and brain morphology remains inconclusive.
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Clinical communication: 6 misunderstandings of imaging test billing
Time of Update: 2022-10-02
Myth 2Routine transcribed CT scan makes it easy to find nasal fracturesNasal fractures are common, but due to the special anatomical site of the nasal bone, x-ray projection requirements are high and often difficult to meet clinical needs.
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Cell: Li Dan/Liu Cong co-discovered microglia receptors mediating neuroinflammation α-syn fibers in Parkinson's disease
Time of Update: 2022-10-02
111401Open reprints are welcome to be forwarded to the circle of friends and WeChat groups In this study, the research team used a series of experimental methods of biochemistry, biophysics and cell biology to explore the molecular mechanism of RAGE's interaction with α-Syn pathological fibers and their role in α-syn fibers in causing cellular inflammatory responses.
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Mol Psychiatry—Xiong Wei's research group analyzes the neural circuit mechanism of fear enhancing the shock reflex
Time of Update: 2022-10-02
Written by - Guo Weiwei, Xiong Weiwei Editor-in-Chief - Wang Sizhen Editor - Yang Binwei startle reflex is a highly conservative instinctive defense behavior possessed by mammals, which involves the r
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Science: The function of microglia is being tapped again! Studies have revealed its involvement in the relief of neuropathic pain
Time of Update: 2022-10-02
Figure 1: Necessity of spinal cord CD11c+ microglia for spontaneous pain reliefCD11c+ microgliaSpontaneous pain relief is caused by IGF1To explore what molecules CD11c+ microglia play a role in, the researchers performed RNA sequencing of CD11chigh and CD11cneg microglia in the spinal cord after PNI, and the results showed that the expression of Igf1 in CD11chigh was significantly higher than that in CD11cneg.
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Types of hernia and their imaging characteristics
Time of Update: 2022-10-02
Note widening of the temporal angle of the contralateral ventricle (*)Schematic of laterally descending cerebellar curtain hiatus hernia with compression of the posterior cerebral artery (white short arrow), compression of the oculomotor nerve (black short arrow), attention to ipsilateral pupil dilation (black long arrow), contralateral ventricular temporal angle dilation (*).
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【Classic case analysis】Picture image diagnosis and analysis of MRI cases of chronic hepatic encephalopathy
Time of Update: 2022-10-02
【Diagnostic imaging】:Chronic hepatic encephalopathy【Diagnostic points】:【Clinical signs and symptoms】:【Differential diagnosis】: Picture image diagnostic analysis of MRI cases of chronic hepatic encephalopathy【Clinical history】: Patient, male, 54 years old, suffering from hepatitis C, the first symptoms are tremor and mental abnormalities.
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Neurology: Synaptic and axonal integrity, with a huge impact on gray matter atrophy
Time of Update: 2022-10-02
The harmful effects of CSF AD protein abnormalities on the medial temporal lobe and total gray matter volume were detected only in people with high (more abnormal) levels of CSF synaptoprotein, even in clinically normal adults.
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Neurology: Effects of epilepsy on quality sleep during pregnancy and postpartum
Time of Update: 2022-10-02
Recently, a study published in Neurology aims to understand how pregnant women with epilepsy are affected by sleep during pregnancy and postpartum and non-pregnant epilepsy during comparative periods of time relative to healthy pregnant women.
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Cereb Cortex—Yu Yuguo teamed up to construct a human brain energy and activity map to reveal the law of energy distribution
Time of Update: 2022-10-02
Written by Chen Zimei, Yu YuguoResponsible editor - Wang SizhenEditor—Binwei YangThe human brain consumes a lot of energy, and how to effectively allocate the energy that occupies 20% of the body's en
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MRI shows that decreased density of white matter veins is associated with neurodegeneration and cognitive impairment in the elderly
Time of Update: 2022-10-02
Figure 4 Relationship between WM venous density and clinical cognitive assessmentIn this study, the authors quantitatively assessed venous oxygen saturation-dependent visibility of the WM venous vasculature on high-resolution SWI in a group of older adults.
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9.21 World Alzheimer's Day Special Edition Stroke: Can you not be demented when you are old? AHA announces the most comprehensive prevention and control factors!
Time of Update: 2022-10-02
International guidelines for evidence-based prevention of AD recommend that people under 65 years of age should maintain a healthy lifestyle and avoid hypertension (Class I recommended, Level A4 evidence); In patients with orthostatic hypotension, their cognitive status (grade I recommended, grade A4 evidence) should be closely monitored.
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Imaging characteristics of progressive multifocal leukoencephalopathy Have you mastered them?
Time of Update: 2022-10-02
Key points of diagnostic imaging:single or multiple asymmetric white matter lesions characterized by low T1 and high T2 signals, with limited marginal diffusion visible, which supports the diagnosis of demyelinating lesions;Most lesions are in the pericerebral white matter and cortex, showing a fan-shaped U-fiber shape;Occasional cerebellar and brainstem involvement;Gray matter involvement is uncommon;The placeholder effect is not obvious;Occasionally with the edge of the lesion and scattered within the lesion punctate enhancement.
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NatMed: marker for neurodegenerative diseases
Time of Update: 2022-10-02
3) Biomarkers for α-synuclein pathologyAlthough α-synuclein can be accurately detected in CSF, due to its low specificity, it cannot distinguish well between various neurodegenerative diseases and is not used much in clinical practice and trials.
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CT grade for acute pancreatitis
Time of Update: 2022-10-02
Grade E: Fluid accumulation in 2 or more of the multiple spaces around the pancreas, or gas shadows in the pancreatic parenchyma and fat gap around the pancreas, the formation of pancreatic parenchyma or peripancreatic abscess, and the significant decrease in hematuria amylase.
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Obstructive hydrocephalus (midbrain aqueous tube stenosis)
Time of Update: 2022-10-02
Hydrocephalus (Hydrocephalus) is more common after various cranial trauma or intracranial masses, so that cerebrospinal fluid absorption disorders, circulatory obstruction or excessive secretion and c
