WIREs Anhui Medical University Wang Xianwen team nanotechnology in polymorphoblastoma: emerging treatment strategies

Glioblastoma multiforme (GBM) is one of the most common forms of primary invasive brain tumors, according to statistics, the median survival of the tumor after diagnosis is about 14.
6 months, although after strong intervention and treatment, almost all GBM patients have a tumor recurrence, and its 5-year survival rate is about 5%.


At present, the main clinical treatment strategies include surgical resection, radiotherapy and chemotherapy, but due to the heterogeneity of tumors, blood-brain barrier, glioma stem cells and DNA damage repair mechanisms, etc.
, to some extent hinder the effective treatment
of GBM.

With the rise of nanotechnology, the emergence of new concepts such as nano-diagnosis and nano-therapy allows us to apply it to cancer treatment, overcome the difficulties encountered in the previous treatment process, and have good application prospects
.

Professor Wang Xianwen's team from Anhui Medical University has been working on the construction of nanodrug carriers and their applications
in tumor treatment, antibacterial and inflammatory therapy.

With the development of nanotechnology and the continuous deepening of research in interdisciplinary fields such as biomedicine, nanomedicine has become the current research hotspot, nanotechnology-based tumor treatment such as: acoustic-dynamic therapy, chemical dynamic therapy, photodynamic and photothermal therapy and other strategies, because of its unique advantages gradually attracted the attention of many scientific researchers, nanomedicine is expected to surpass the traditional cancer treatment methods such as surgical resection of tumors, chemotherapy and radiotherapy, becoming the best treatment technology
.

Recently, the team was invited to write about the application and research progress of nanotechnology-based monotherapy (such as chemotherapy) and combination cancer treatment strategies (such as chemotherapy-based combination therapy), briefly described the treatment status of GBM, and systematically summarized nanotechnology-based monotherapy (such as chemotherapy) and combination therapies {such as: chemotherapy-based combination radiotherapy (RT), acoustic-dynamic therapy (SDT), photodynamic therapy (PDT), chemodynamic (CDT) and other mechanisms of cancer treatment} (Figure 1).


Because any single treatment method for malignant tumors has its own limitations, and the combination of multiple treatment strategies can solve this problem very well, has many advantages, on the one hand, combination therapy can significantly improve the efficiency of tumor treatment, on the other hand, it can effectively reduce the use of drug doses, thereby reducing dose-dependent drug toxicity, and alleviating the physical and psychological trauma
caused by radiotherapy and chemotherapy for patients.

The authors believe that the future development direction of nanotechnology in the field of cancer will focus on the development of multifunctional nano-sensitizers and the construction of collaborative nanoplatforms, for example, our team studied the role of titanium-based nanosensitizers in tumor therapy in the early stage, and found that it has excellent SDT treatment efficiency, and has CDT ability and the ability of depleted glutathione (GSH) to regulate the tumor microenvironment, which can enhance the tumor killing effect.
Therefore, nanodrugs can design multifunctional nano-sensitizers according to the proliferation and invasion mechanisms of different types of tumors, and the treatment methods combined with traditional radiotherapy and chemotherapy can maximize the effect
of tumor eradication.

In summary, this review systematically summarizes the treatment strategies based on nanotechnology combined with traditional GBM treatment methods, and discusses the application of such technologies in different types of intracranial tumors, providing guidance for the clinical treatment strategy of GBM
.

Director Cheng Hongwei of the First Affiliated Hospital of Anhui Medical University, Professor Qian Haisheng and Professor Wang Xianwen of Anhui Medical University are the corresponding authors
of this review.

Original link:

https://wires.

Figure 1 Nanotechnology-based glioma treatment

About the Corresponding Author

Wang Xianwen, Ph.

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