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Wei Wensheng's research group from the School of Life Sciences reported the upgraded version of RNA editing technology "LEAPER 2.0"
Time of Update: 2022-03-02
Although LEAPER has considerable potential in scientific research and disease treatment, this technology still has certain limitations: First, LEAPER uses endogenous editing enzymes, which limits its editing efficiency; in addition, arRNAs with a certain length may make the target Off-target editing occurs at bases adjacent to the editing site, so this technology needs to be optimized and upgraded .
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CROPSR: A New Tool to Accelerate Gene Discovery
Time of Update: 2022-03-02
CROPSR is the first open-source software tool for genome-wide design of CRISPR experiments and evaluation of guide RNA (gRNA) sequences, created by scientists at the Department of Energy-funded Bioenergy Research Center (BRC) .
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Sci Rep: Nanoplastics can enter and penetrate cell membranes
Time of Update: 2022-03-02
Researchers at the University of Eastern Finland have used molecular modeling methods to study the movement of nanoplastics in thin film structures .
With the help of molecular models, researchers from the University of Eastern Finland's Faculty of Pharmacy have analyzed the behavior and transport of nano-microplastics in bilayer membranes that mimic cell membranes .
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"Science Advances" millipedes use sucking pump to ingest liquid food
Time of Update: 2022-03-02
A research team from Germany and Switzerland, led by the Leibniz Institute for the Analysis of Biodiversity Change (LIB) and the University of Bonn, has now shown that millipedes also use sucking pumps to ingest liquid food .
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Journal of Cell Biology: A new phenomenon that cell migration patterns regulate migratory body formation
Time of Update: 2022-03-02
On February 18, the research group of Jiu Yaming of the Pasteur Institute, Shanghai, Chinese Academy of Sciences published an article online in the Journal of Cell Biology entitled " Cell migration o
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Joint research by Kan Haidong's research group reveals the impact of cold wave on death risk and disease burden of Chinese residents
Time of Update: 2022-03-02
Daily mortality (non-accidental total death and heart and lung disease mortality) and weather conditions (daily average temperature and daily average relative humidity) data were statistically analyzed to explore the impact of cold waves on the mortality risk of Chinese residents and the time lag pattern, The disease burden attributable to the cold wave was also assessed .
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Ultra-intensive laser irradiation of graphene achieves high-energy ion acceleration for cancer treatment
Time of Update: 2022-03-02
Recently, a research team led by Osaka University in Japan irradiated the world's thinnest and strongest graphene target with a super-strong J-KAREN laser at the Japan Quantum Science and Technology Research and Development Institute, thereby achieving direct high-energy ion acceleration and turning on the laser drive.
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Immunity: Molecular 'criminal' responsible for cell death and inflammation discovered
Time of Update: 2022-03-02
Image: Associate Professor James Vince, PhD students Daniel Simpson and Dr Rebecca Feltham A study led by wehi has identified a molecular "culprit" that causes damage levels of cell death and inflammation in the body .
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Science warns: Luminous tumor markers may interfere with cancer research, causing reproducibility problems
Time of Update: 2022-03-02
But he and others say the lab's experience reflects a broader question in mouse studies of immunotherapy, a powerful therapy that harnesses the immune system to defeat tumors: the glowing proteins that biologists use to track cancer cells, usually from fireflies Or borrowed from jellyfish, and may be sparking their own immune attack on cells .
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Yu Hongjie's research group has made a series of progress in the field of new coronary pneumonia school closures and vaccine immunization effects
Time of Update: 2022-03-02
To this end, Yu Hongjie's research group systematically collected the immunogenicity data of COVID-19 vaccines with different technical research and development routes, and used proven statistical models to predict the effects of COVID-19 vaccines against Delta variant strains on virus infection, symptomatic and severe diseases Protective efficacy over time for three clinical endpoints (basal and booster) .
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Specific 'mathematical neurons' in the brain
Time of Update: 2022-03-02
"We found that different neurons are activated during addition and subtraction," explains Prof.
"In the study, tiny electrodes were implanted in the brains of five women and four men to measure the activity of individual neurons .
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Science identifies key protein that could be used to extend healthy human lifespan
Time of Update: 2022-03-02
They found that the thymus glands of the calorie-restricted participants lost fat and increased functional volume two years later, meaning they produced more T cells than at the start of the study .
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Researchers artificially replicate the brain's learning and forgetting functions using a magnetic system
Time of Update: 2022-03-02
Here, the researchers' proposal is to use magnetic ion technology to control the magnetic properties of materials through voltage-driven ion migration, which greatly reduces power consumption and enables energy-efficient data storage .
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Oral drug made from human feces has successfully passed clinical trials
Time of Update: 2022-03-02
Results of the study were published in the January 20, 2022 issue of the NEJM journal, titled "SER-109, an oral microbiome therapy for recurrent Clostridium difficile infection .
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New Yale imaging scans reveal culprit for cognitive decline in Alzheimer's
Time of Update: 2022-03-02
Christopher van Dyck, professor of psychiatry, neurology and neuroscience at the Yale School of Medicine and director of the Yale Alzheimer's Disease Research Center, said, Yale researchers can now track the loss of synapses in patients to better understand the development of cognitive decline in individuals .
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Defeating leukemia cells by depriving them of energy
Time of Update: 2022-03-02
"Furthermore, activation of AMPK by GSK621 sensitized cells to the effects of another pharmacological drug, venetoclax, which is now widely used to treat acute myeloid leukemia, albeit with limited efficacy when used alone .
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Advances in research on the battle between viruses and human cells
Time of Update: 2022-03-02
"This paper seeks to understand the mechanisms that allow these RNAs to escape degradation," said senior author Mandy Muller, assistant professor of microbiology .
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Autism is different in girls' brains
Time of Update: 2022-03-02
The study's lead author, Kaustubh Supekar, PhD, a clinical assistant professor of psychiatry and behavioral sciences, said: "When a disorder is described in a biased way, the diagnostic approach is also biased .
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Science: Exposure to chemical cocktails during pregnancy alters brain development
Time of Update: 2022-03-02
"By linking different scientific methods, the researchers were able to show that 54 percent of the children included in the Selma study were at risk for language delay (30 months of age) and their prenatal exposure to a mixture of chemicals at levels above levels would affect neural development .
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Neuron dendrites help neurons perform complex calculations
Time of Update: 2022-03-02
In a study in mice, the researchers first showed that three distinct types of input enter the pyramidal neurons of the RSC: from the visual cortex to the basal dendrites, from the motor cortex to the apical oblique dendrites, and from the lateral thalamic nucleus (Visual Processing Zone) into clustered dendrites .
