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Nature: Mitochondrial fission requires protein DRP1, but not dynein
Time of Update: 2022-03-02
Mitochondrial fission, which is required for the maintenance of the mitochondrial network, relies on a GTPase called dynamin-related protein 1 (DRP1, also known as DNM1L) .
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Are there better treatments for infections with extremely high mortality rates?
Time of Update: 2022-03-02
▲HSPC infusion can significantly improve the survival rate of mice with sepsis (Image source: Reference [2])However, the infusion of HSPCs did not reduce the number of bacteria in the mice, it reduced the risk of death by producing immune cells to suppress undesirable inflammatory signals .
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Is America's National Bird in Danger?
Time of Update: 2022-03-02
On February 17, local time, "Science" magazine published research showing that the situation of the bald eagle, the national bird of the United States, is worse than previously thought .
The Bald Eagle is the national bird of the United States .
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Ascentage Pharma and Pfizer reached a clinical cooperation agreement to jointly advance the clinical development of APG-2575 combined with CDK4/6 inhibitor Aiboxin® for the treatment of metastatic ER-positive HER2-negative breast cancer
Time of Update: 2022-02-27
The company has previously simultaneously advanced the clinical development of APG-2575 for the treatment of various hematological tumors in the United States, Europe, China and Australia .
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Leadstar Bio's "International Invention Patent for Non-invasive Monitoring of Tumor Progress" was authorized by the U.S. Patent Office
Time of Update: 2022-02-27
In the early stage, paired clinical whole exome sequencing (CWES) technology was used, which can cover the whole picture of tumor gene spectrum; and through the unique CSMT international Patented algorithms construct tumor-specific DNA mutation fingerprints, based on which patient-specific monitoring panels are designed and customized .
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Is excessive sleepiness a disease?
Time of Update: 2022-02-27
com/news-releases/harmony-biosciences-announces-fda-approval-of-wakix-pitolisant-a-first-in-class-medication-for-the-treatment-of-excessive-daytime-sleepiness-in-adult -patients-with-narcolepsy-300902091.
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Bringing lung cancer patients to a cure, blockbuster immune combination therapy significantly prolongs cancer-free survival
Time of Update: 2022-02-27
Today, Bristol-Myers Squibb (BMS) announced that its blockbuster immune checkpoint inhibitor Opdivo (nivolumab), in combination with chemotherapy, was used before surgery in patients with early-stage non-small cell lung cancer (NSCLC) to significantly prolong cancer-free survival time .
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Scientific view of head shape correction experts: orthopedic helmets are effective to a certain extent!
Time of Update: 2022-02-26
For children with abnormally severe cranial shape or in the recovery period after surgery, orthopedic helmets are an effective method and have been approved by domestic and foreign drug administrations .
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Next-Generation 'Synthetic Lethal' Therapy Receives FDA Fast Track Designation
Time of Update: 2022-02-26
▲ZN-c3 exhibits anticancer activity in various solid tumor types (Image source: Zentalis official website)References:ZENTALIS PHARMACEUTICALS ANNOUNCES FAST TRACK DESIGNATION GRANTED BY THE US FDA TO ZN-C3 FOR THE TREATMENT OF UTERINE SEROUS CARCINOMA.
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Lusheng and AstraZeneca reached a strategic cooperation to jointly promote ovarian cancer HRD detection in Southeast Asia
Time of Update: 2022-02-26
10, 2021 /PRNewswire/ -- AstraZeneca Singapore and Lucence announce the signing of a strategic collaboration agreement to provide homologous recombination repair for newly diagnosed patients with advanced ovarian cancer in Southeast Asia Defect (HRD) detection .
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Novartis leukemia therapy starts phase 3 clinical trial in China and just got approval in the US
Time of Update: 2022-02-26
TextPharmaceutical GuanlanOn November 15, the China Drug Clinical Trial Registration and Information Publicity Platform revealed that Novartis has initiated Phase 3 treatment of ABL001 in newly diagnosed Philadelphia (Ph) chromosome-positive chronic myeloid leukemia (CML) adult patients in the chronic phase in China.
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Coronary heart disease bypass or stent which is better?
Time of Update: 2022-02-26
Overall, in patients with three-vessel coronary stenosis, FFR-guided stenting was inferior to bypass surgery in terms of the 1-year composite rate of death, MI, stroke, or repeat revascularization .
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Only half a month after the clinical trial application was approved, the first subject was administered in the US Phase I clinical trial of ASC43F
Time of Update: 2022-02-26
Gan Lai has three clinical-stage nonalcoholic steatohepatitis drug candidates targeting fatty acid synthase (FASN), thyroid hormone ß receptor (THRß) and farnesoid X receptor (FXR) and three fixed-dose combinations preparation .
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Biogen Aduhelm causes cerebral edema in more than one-third of subjects
Time of Update: 2022-02-26
It is reported that before the controversial approval, researchers had observed cases of amyloid-related imaging abnormalities (ARIA-E) or brain edema in subjects in multiple Aduhelm trials .
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Inventory: 24 important milestones in the human fight against diabetes in the past 100 years
Time of Update: 2022-02-26
In 1965, an important histological study found that in patients with early-onset diabetes mellitus (later called type 1 diabetes), insulin-secreting beta cells were greatly reduced, and most patients with acute disease had peri- and intra-islet inflammation.
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Corning Jereh KN046 combined with chemotherapy in the treatment of advanced pancreatic cancer phase III clinical application approved by CDE
Time of Update: 2022-02-26
Albumin paclitaxel combined with gemcitabine (AG regimen) is the standard first-line treatment regimen for locally advanced unresectable or metastatic pancreatic ductal adenocarcinoma, but the ORR of this regimen is less than 25%, and it progresses rapidly, so there is a huge clinical need .
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How many steps will it take to build a hospital in space?
Time of Update: 2022-02-26
On the basis of a clear diagnosis, providing timely and effective emergency treatment and medical treatment is the core task of the space hospital, and it is also the bottleneck of the current development of space clinical medicine .
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Combination of precision therapy for first-line treatment of leukemia significantly prolongs patient survival time
Time of Update: 2022-02-26
Daiichi Sankyo announced that the oral FLT3 inhibitor quizartinib, in combination with standard chemotherapy, met its primary endpoint in a Phase 3 clinical trial in the first-line treatment of patients with FLT3-ITD-mutated acute myeloid leukemia (AML).
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20 years of deteriorating eyesight to see again!
Time of Update: 2022-02-26
▲The mechanism of action of GS030 (Image source: GenSight official website)A few months ago, Nature Medicine published the first case report of vision recovery in a patient receiving low-dose (5^10 vg) gene therapy: a blind patient who was diagnosed with the disease 40 years ago, after treatment, has been able to identify, Count, locate, touch different objects .
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A new target for Alzheimer's disease - MEF2
Time of Update: 2022-02-26
Environmental richness-induced transcriptional signatures associated with MEF2 activity (Source: Science Translational Medicine)And when the researchers knocked down the MEF2 gene in the frontal cortex of wild-type mice, the mice developed cognitive impairment, no longer able to reap the cognitive benefits of the enriched environment, and neurons became hyperexcited .
