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Nature Metabolism: Fat cells behind obesity-related inflammation
Time of Update: 2022-03-06
Studies have shown that weight gain can lead to changes in phosphocreatine/creatine metabolism, which can lead to inflammation in fat cells .
"We believe that impaired creatine metabolism in fat cells causes an 'energy crisis' that causes the body to compensate by increasing glucose utilization .
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Du Weiguo's research group published a review article on embryonic behavior and physiological ecology in Biological Reviews
Time of Update: 2022-03-06
The review paper, for the first time proposing embryo ecology and its theoretical framework (Figure 1), systematically summarizes the latest progress in embryo behavior and physiological ecology .
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Cell Sub-Journal: "Mathematical Neurons" in the Brain
Time of Update: 2022-03-06
The brain activity thus showed very accurately the task the test subjects were currently calculating: The researchers fed the activity patterns of these cells into a self-learning computer program .
There, the researchers also found that nerve cells were particularly active during addition and subtraction .
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Chinese scholars have made progress in the research on the mechanism of osteoarthritis
Time of Update: 2022-03-06
: 81991513, 82022047, 81630066, 81972100), the research team of Professor Xiao Guozhi and Cao Huiling of Southern University of Science and Technology and the team of Professor Bai Xiaochun of Southern Medical University have found that the focal adhesion protein Kindlin-2 can be regulated by The Stat3-Runx2 pathway maintains articular cartilage homeostasis and plays an important role in combating the occurrence and development of osteoarthritis .
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Aimu Medical's AM712 clinical application was approved by the FDA
Time of Update: 2022-03-06
Following the approval of this IND application, AMM Medical will initiate a Phase 1 clinical trial in the United States as soon as possible to study the safety, tolerability, pharmacokinetics and pharmacokinetics of AM712 (ASKG712) in patients with neovascular AMD.
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Nature: New atlas of cells that transport blood to the brain
Time of Update: 2022-03-06
Their research also revealed differences between brain blood vessel cells from healthy and Huntington's disease patients, which could provide new targets for potential treatments for Huntington's disease .
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A model for predicting response to gastric cancer treatment
Time of Update: 2022-03-06
"We tried to use genome sequencing to build a model to predict the likelihood that a patient would benefit from chemotherapy or immunotherapy," said Dr.
"We are pleased that our 32-gene fingerprint not only provided prognostic information, but also predicted patient benefit from chemotherapy and immunotherapy," said Dr.
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GlaxoSmithKline's Benlysta gets new indication in China
Time of Update: 2022-03-06
Benlysta was previously approved as an add-on therapy for the treatment of active systemic lupus erythematosus (SLE) in children and adults 5 years of age and older .
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Potential new approach to treating diabetes complications
Time of Update: 2022-03-05
"In our study, we wanted to find out whether the overproduction of cellular ROS in diabetes is due to an impaired response to hypoxia due to inhibition of HIF-1 by high blood glucose levels .
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The Painful Fact of Added Sugar: What Excessive Fructose Consumption Can Do to Our Body
Time of Update: 2022-03-05
A comprehensive review explains how excessive intake of fructose - a common additive in sweetened foods and beverages - can lead to disease .
A new review explains how excessive intake of fructose, a common additive in sweetened foods and beverages, can lead to disease .
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Science sub-journal: Fat cells in skin fight acne (treatment with no side effects)
Time of Update: 2022-03-05
In this study, we looked at the cells outside the hair follicle and found that they play an important role in controlling bacteria and acne development .
To the researchers' surprise, the drug enhanced the expression of antimicrobial peptides after treatment, uncovering another unknown mechanism why retinoids help treat acne .
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Chinese scholars and overseas collaborators have made progress in the uplift of the Central Valley and the formation of the Qinghai-Tibet Plateau
Time of Update: 2022-03-05
, has broken through the isolation of circles and scientific boundaries, and quantitatively restored the uplift and extinction process of the central valley of the Qinghai-Tibet Plateau 38 to 29 million years ago .
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Cell Insight Lan Ke / Wu Shuwen's team discovered a new blocking inhibitor against enterovirus invasion and infection
Time of Update: 2022-03-05
In conclusion , this work found that PTC-209HBr has broad-spectrum anti-enterovirus activity and revealed its anti- enterovirus molecular mechanism , while exploring the resistance and adaptive escape of enteroviruses to PTC-209HBr The evolutionary pathway has laid an important foundation for the further development of new anti-enterovirus drugs with high efficiency and low toxicity .
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Human nose model reveals first steps of SARS-CoV-2 and RSV infection
Time of Update: 2022-03-05
"In the case of respiratory viruses, such as SARS-CoV-2 and RSV, infection begins when people inhale the virus," said corresponding author Pedro Piedra, PhD, professor of molecular virology, microbiology, pediatrics, pharmacology and chemical biology at Baylor University.
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The South China Botanical Garden found that the new genus Huchimingia of the leguminous family in Asia
Time of Update: 2022-03-05
Therefore, among the 16 groups recognized by Dunn (1912) , 4 groups were subsequently promoted to genus by other scholars: the white flower group ( Millettia sect.
podocarpa (Dunn) ZQ Song] , distributed in China ( Yunnan ) , Laos, Myanmar and Vietnam; three-leaf Qiming bean [ H.
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In solving a decades-long mystery, scientists discover that schizophrenia may originate in the brain
Time of Update: 2022-03-05
The massive increase in glutamate signaling in the dentate gyrus, caused by reduced SAP97 function, also led to marked deficits in contextual episodic memory in rodents—a hallmark of schizophrenia .
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Memory formation is influenced by the development of brain networks in youth
Time of Update: 2022-03-05
As our brains mature, precise communication between two key memory regions facilitates the formation of lasting memories'As you age, your brain is learning to multitask', study says"By understanding how things came to be, in this case, memory provides us with a window into why it eventually falls apart .
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Human olfactory mucosal cell model
Time of Update: 2022-03-05
Following tissue processing, the researchers applied a robust single-cell RNA-sequencing approach to characterize patient-derived olfactory mucosal cells, located in the upper half of the nasal cavity .
"Our current work focuses on understanding in detail how viral infection or exposure to air pollutants affects olfactory mucosal cells, " says Katja Kanninen.
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eDNA is a useful tool for early detection of invasive mud crabs
Time of Update: 2022-03-05
"From a management perspective, the value of this tool is really in places that live in more remote locations or have a lot of coastlines, like Alaska, where green crabs haven't been detected," said author Emily Grason, a marine ecologist leading the Washington Sea Grant Crab Team .
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Sperm or egg?
Time of Update: 2022-03-05
Image: Various species of the genus Macrostomum: This planarian is transparent and allows the size of male and female reproductive organs in live animals to be determined under a microscope .
