Under the support of the National Natural Science Foundation of China (Grant Nos.
Osteoarthritis is a major chronic disease that endangers human health, manifested as slowly developing joint pain, tenderness, stiffness, joint swelling, limited mobility and joint deformity
The collaborative research team found that the focal adhesion protein Kindlin-2 was highly expressed in the articular chondrocytes of healthy adult mice, while its expression was significantly reduced in the articular chondrocytes of aging mice
This study not only provides a new understanding of the maintenance mechanism of articular cartilage cell homeostasis, but also provides a new potential intervention target for the prevention and treatment of osteoarthritis
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