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The group of Mikael Rydén and Niklas Mejhert investigated the causes of adipose tissue inflammation in obese patients
.
Studies have shown that weight gain can lead to changes in phosphocreatine/creatine metabolism, which can lead to inflammation in fat cells
"We believe that impaired creatine metabolism in fat cells causes an 'energy crisis' that causes the body to compensate by increasing glucose utilization
.
This stimulates genes that contribute to chronic inflammation in the body, thereby increasing the risk of insulin resistance.
Fat cells may hold key to future treatments
Adipose tissue is composed of many different cell types, and it is not entirely clear which cell types are responsible for impaired adipose tissue function in obesity and insulin resistance
.
Previous studies have focused on the role of immune cells in adipose tissue, but anti-inflammatory treatment did not appear to have any effect on adipose tissue function
Original search:
Impaired phosphocreatine metabolism in white adipocytes promotes inflammation .