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Jiang Xinyi's team at Shandong University developed a drug delivery system based on Th17 cells that can be delivered across the blood-brain barrier to treat multiple sclerosis
Time of Update: 2023-02-03
In recent years, Professor Jiang Xinyi's team has made a series of important achievements in gene therapy and controlled delivery of nucleic acid drugs, which have been published in Nature Nanotechnology, Science Translational Medicine, Nature Communications, PNAS, Science Advances, Advanced Materials and other internationally renowned academic journals 。 Multiple sclerosis (MS) is an inflammatory autoimmune disease of the central nervous system (CNS), characterized by demyelinating, axonal damage, and neurodegeneration, for which there is currently no cure.
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Cell Metabolism Thousands of unknown microproteins have been discovered in fat cells, one of which can increase appetite
Time of Update: 2023-02-03
Profiling Mouse Brown and White Adipocytes to Identify Metabolically Relevant Small ORFs and Functional Microproteins From left: Alan Saghatelian and Thomas MartinezObesity and metabolic diseases, such as diabetes, are very common in the United States.
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Challenging nutritionist perception: honey can improve key indicators of cardiometabolic health
Time of Update: 2023-02-03
In a systematic review and meta-analysis of clinical trials, researchers found that honey consumption was associated with lower fasting blood sugar, total and LDL cholesterol ("bad" cholesterol), triglycerides, and markers of fatty liver disease.
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The University of California, Berkeley, has discovered that "viral toxins" can cause severe COVID-19
Time of Update: 2023-02-03
The study shows how part of the SARS-CoV-2 "spike" protein can disrupt cellular barriers inside blood vessels in body organs, such as the lungs, leading to so-called vascular leaks.
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New study: Daytime sleepiness, poor nighttime sleep and snoring all increase the risk of permanent blindness
Time of Update: 2023-02-03
To explore these questions further, the researchers set out to determine the risk of glaucoma in people with different sleep behaviors: insomnia; Sleeping too much or too little; late or early riser ("owl" or "lark"); Daytime sleepiness; and snoring.
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Protein "anchors" were found to play a key role in the action of the neurotransmitter aminobutyric acid
Time of Update: 2023-02-03
essayFilamin A organizes γ?aminobutyric acid type B receptors at the plasma membrane The Membrane Proteins and Receptors Centre (COMPARE), a research institute at the University of Birmingham in collaboration with the University of Nottingham, has developed a new pioneering research method to discover the role of serine protein A in GABA activity.
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The novel protein domain plays an important role in photosynthetic system II assembly and angiosperm photoautotroph
Time of Update: 2023-02-03
com/retrieve/pii/S1674205222004518 Recently, Mo Xiaorong's research group from the Institute of Plant Biology, College of Life Sciences, Zhejiang University, published a report entitled " A novel protein domain is important for photosystem II complex assembly and photoautotrophic growth in angiosperms".
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Have a fever after vaccination? Scientists have discovered new potential connections
Time of Update: 2023-02-03
This is the first study to highlight the relationship between fever induction and antibody levels at different time points after the third dose of mRNA-1273 vaccine.
This is the first study to highlight the relationship between fever induction and antibody levels at different time points after the third dose of mRNA-1273 vaccine.
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The School of Electronics has made a new breakthrough in quantum sensing technology of two-dimensional electromagnetic force
Time of Update: 2023-02-03
Force is the basic object of study in physics. The measurement of weak forces has always been a key means to verify basic physics and discover new physics, such as discovering new physics beyond the
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New evidence: Raising mitochondrial membrane potential is enough to slow down aging and prolong life! Research progress on mitochondria and aging mechanisms
Time of Update: 2023-02-03
" "Here, we show that the optogenetics of increasing mitochondrial membrane potential using photoactivated proton pumps in adulthood in nematodes can improve the age-related phenotype of Caenorhabditis elegans and extend their lifespan.
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The latest clinical data shows that the domestic new crown oral drug azvudine is safe and effective
Time of Update: 2023-02-03
The results of clinical studies have proved that azvudine can significantly shorten the nucleic acid conversion time, accelerate virus elimination, significantly reduce viral load, reduce symptoms and shorten the course of disease in patients with mild and moderate SARS-CoV-2 infection, and has good safety and no significant impact on liver and kidney function of patients, which is safe and effective.
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Nature sub-issue: Ultra-thin devices have the potential to transform islet cell transplantation
Time of Update: 2023-02-03
Article Mplantable niche with local immunosuppression for islet allotransplantation achieves type 1 diabetes reversal in rats Image: The new blood vessel implantable cell homing and encapsulation (NICHE) device is about a quarter of the size.
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"A life of strength" eggs, for the offspring, strive to repair radiation-damaged sperm DNA
Time of Update: 2023-02-03
Scientists have observed a 10-fold higher prevalence of childhood leukemia near the Sellafield nuclear power plant in the United Kingdom than in other regions, and a higher relative risk of non-Hodgkin lymphoma, particularly in children whose fathers had high radiation doses recorded before pregnancy.
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Use light energy to extend human life?! New research in Nature has found that light-activated proton pumps produce cellular energy
Time of Update: 2023-02-03
A new study published in the journal Natural Aging borrows a page from the field of renewable energy and shows that genetically engineered mitochondria can convert light energy into chemical energy that cells can use, ultimately extending the lifespan of C.
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【Scientific Research News】Professor Li Zifu of the School of Life Sciences, Huazhong University of Science and Technology and Professor Sun Chaoyang of Tongji Hospital have made new progress in the direction of tumor targeted nanomedicine
Time of Update: 2023-02-03
On December 16, 2022, Professor Li Zifu, School of Life Sciences, Huazhong University of Science and Technology, National Engineering Research Center for Nanomedicine, and Professor Sun Chaoyang of Tongji Hospital co-published a title entitled "Acta Biomaterialia Codelivery of adavosertib and olaparib by tumor-targeting nanoparticles for augmented efficacy and reduced toxicity".
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Hu Jiazhi's group and collaborators in the School of Life Sciences used Cas9TX to achieve efficient and safe gene editing in a mouse model of age-related macular degeneration
Time of Update: 2023-02-03
In the in vivo gene editing therapy model of age-related macular degeneration (AMD), this work quantitatively reveals for the first time the occurrence mode and frequency of chromosomal translocation and adeno-associated virus fragment insertion of CRISPR-Cas9 in the process of gene editing in vivo, and greatly reduces the production of these byproducts in the in vivo gene editing process by using the Cas9TX variant previously developed by the research group.
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Nature Cancer: Triple immunotherapy has the potential to treat pancreatic cancer
Time of Update: 2023-02-03
Researchers at the University of Texas MD Anderson Cancer Center have discovered a novel immunotherapy combination that targets checkpoints in T cells and myelosuppressor cells, successfully reprogrammed the tumor immune microenvironment (TIME), and significantly improved anti-tumor responses in preclinical models of pancreatic cancer.
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Misfolded proteins in liver cells contribute to the development of liver cancer
Time of Update: 2023-02-03
"The findings suggest that gene therapy for hemophilia may increase the risk of liver cancer in some patients after years of treatment.
"The findings suggest that gene therapy for hemophilia may increase the risk of liver cancer in some patients after years of treatment.
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Science sub-journal: A new target for advanced nonalcoholic fatty liver disease
Time of Update: 2023-02-03
Using the latest techniques — including monocytes sequencing of mouse and human liver tissue and advanced mouse 3D glass imaging to characterize critical scarring liver cells — researchers have discovered new drug candidate targets for the treatment of nonalcoholic fatty liver disease (NAFLD).
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Nature Aging: A therapy to remove senescent cells
Time of Update: 2023-02-03
JAX is poised to make a significant contribution to SenNet by analyzing senescent cells in the kidneys, placenta, pancreas and heart, as well as all tissues associated with chronic aging diseases.
