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Neuron: Scientists reveal the neural mechanisms that induce social avoidance behavior after long-term withdrawal from analgesic addiction
Time of Update: 2022-10-20
024The images in the article are from referencesFigure 3: KOR reduces serotonin release and causes withdrawal-related social impairmentsummaryIn this paper, it was found that KOR activation after opioid withdrawal inhibits the release of serotonin in the NAc shell region, causing social avoidance behavior.
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Nature | Human brain organoid cell fate regulator
Time of Update: 2022-10-20
The Gray Camp research group co-published a paper entitled Inferring and perturbing cell fate regulomes in human brain organoids, by establishing a Pando analysis framework that integrates multi-omics data and transcription factor binding site prediction.
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How is status epilepticus handled? These 7 points need to be clear
Time of Update: 2022-10-20
*For medical professionals onlyThe focus is on stabilizing the patient's respiratory and circulatory stateStatus epilepticus (SE) refers to frequent recurrences of consciousness that do not fully recover between successive seizures, or that seizures do not stop on their own for more than 30 minutes.
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JAMA has posted a reminder! Postpartum depression can significantly affect infant speech development
Time of Update: 2022-10-20
Click "Read Original" to get more clinical dry goodsOn September 27, 2022, a new study published in JAMA showed that maternal postpartum depression appeared to be associated with infants' verbal perception trajectories.
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Nature back-to-back multiomics maps molecular subtypes of human fetal cerebellar developing medulloblastoma
Time of Update: 2022-10-20
The authors first used transcriptome data from 52,419 single cells and nuclei in the cerebellum of the human fetus (9-21 weeks after pregnancy) to map different molecular subsets of MB back to specific cell types in cerebellar development at the bulk level.
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Does the new crown pneumonia affect our hearing and vestibule?
Time of Update: 2022-10-20
9%experienced acute vertigo attacks 。 They believe that viral infections can damage inner ear cells, cause hearing loss, and some even affect the auditory brainstem; The virus is neuroinvasive, and the presence of coronavirus-related neurootological symptoms, such as tinnitus and balance disorders, has been demonstrated, so there is an association between COVID-19 and auditory-vestibular symptoms.
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Nature Heavyweight: Human brain organoids can be integrated into animal brains to form functional neural circuits
Time of Update: 2022-10-20
1038/s41586-022-05277-w——List of recent popular events——▼October 18, the application and development trend of biopharmaceutical safety detection technologyOctober 16, 2022 / eMedClub News /-- On October 12, 2022, Nature published an article titled " Maturation and circuit integration of transplanted human cortical organoids", researchers transplanted brain-organoids into rats' developing brains and found that brain-like organs can develop and mature normally.
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TAVR fragments were arrested, but strokes were not reduced, is the anti-fragmentation device worth? NEJM
Time of Update: 2022-10-20
PROTECTED TAVR STUDY: FURTHER VALIDATION OF THE SAFETY AND EFFICACY OF TAVR INTRAOPERATIVE BRAIN PROTECTION DEVICESZHANG Yi,CHEN Mao*Department of Cardiology, West China Hospital, Sichuan University*Corresponding authorWith the accumulation of evidence and the iteration of technology, transcatheter aortic valve replacement (TAVR) has become one of the standard treatment methods recommended by guidelines for patients with high-, intermediate, and low-risk severe aortic stenosis.
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Cure before birth – remember the world's first intrauterine spina bifida stem cell treatment
Time of Update: 2022-10-20
" Figure 1 Stem cell patch repairs spina bifida (Source: UC Davis Health Center official website) For more than a decade, Farmer has been working on this human clinical trial of spina bifida.
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Cereb Cortex-Liu Tao's team revealed the accelerated degradation pattern of white matter structure in the elderly
Time of Update: 2022-10-20
Written by Zhao Haichao - Wang Sizhen, Fang YiyiEditor—Summer LeafAging has significant negative effects on human brain structure and cognitive function. In recent years, life-cycle studies have found
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J Neuroinflammation Review—Wenfei Ni/Kailiang Zhou focused on the important role of STING pathway in neuroinflammation and cell death after CNS injury
Time of Update: 2022-10-20
Written by Hu Xinli - Wang Sizhen, Fang YiyiEditor—Summer LeafCentral Nervous System (CNS) injury refers to the damage of the brain and spinal cord to external factors, mainly including traumatic brai
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Decipher the biomarker characteristics of different clinical subtypes of Parkinson's disease!
Time of Update: 2022-10-20
S Tan of Duke-NUS School of Medicine published important research results in the journal NPJ Parkinson's Disease [6], clarifying the different subclinical classifications of PD and revealing the possible mechanism of PD heterogeneity, which provides a clinical reference for achieving more targeted personalized treatment of PD.
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Sci Adv—Sheng Neng-Yin/Mao Bingyu/Ding Yuqiang teamwork discovered a new mechanism of AMPA receptor ubiquitination in the regulation of excitatory synaptic function
Time of Update: 2022-10-20
Source︱“”“” Written by Sheng Nengyin, Ma PengchengResponsible editor—，Editor—Summer LeafThe human brain contains about 10 billion neurons, which are connected to each other through synaptic structures
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Neuron Breakthrough! Academician Luo Liqun's team developed a new method to obtain the in situ proteome on the surface of mammalian cells
Time of Update: 2022-10-20
On October 10, 2022, the Luo Liqun team from Stanford University and the Howard Hughes Medical Institute in the United States published a paper entitled "In situ cell-type-specific cell-surface proteomic profiling in mice" online in Neuron magazine The study proposes a method for extracting the cell surface proteome by extracellular labelling (iPEEL) through extracellular in situ markers.
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Human-mouse hybrid brain is born! The human brain continues to grow after implantation in the mouse brain, but it raises ethical concerns
Time of Update: 2022-10-20
Do you believe it? The human-mouse hybrid brain appeared, and human neurons responded quickly to the stimulation of the mouse! A recent study showed that miniature human brains transplanted into mice
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Remegen Biologics tetacept was designated as an orphan drug by the US FDA for the treatment of myasthenia gravis
Time of Update: 2022-10-20
Myasthenia gravis (MG) is a rare, chronic autoimmune disease caused by autoantibodies against acetylcholine receptors, muscle-specific kinases, or other acetylcholine receptor-related proteins on the postsynaptic membrane, resulting in impaired neuromuscular junction transmission, which can affect eye movement, swallowing, speech, movement, and respiratory function to varying degrees, and about 85% of patients will develop symptoms other than eye muscles, developing generalized myasthenia gravis (gMG), and even myasthenic crisis has been included in China's "First Rare Disease List".
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Carbon dioxide, blood pressure, and postoperative stroke: a retrospective case-control study
Time of Update: 2022-10-20
Figure&TableROMANTICflow chartBivariate analysisSeemingly uncorrelated regression modelBaseline characteristics of the patientCarbon Dioxide, Blood Pressure, and Perioperative Stroke: A Retrospective Case–Control StudyCarbon dioxide, blood pressure, and postoperative stroke: a retrospective case-control studyAbstractROMANTICThe relationship between intraoperative physiologic changes and postoperative stroke is unclear.
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Hypertrophic dura in 1 case
Time of Update: 2022-10-19
At present, it is mainly believed that HCP is a non-specific chronic progressive inflammatory response of the dura mater, and some patients with HCP also show dural reactive hyperplasia and hypertrophy related to autoimmune factors.
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Alzheimer & Dementia: In addition to seeing a doctor, there is also a cognitive disorder that is discovered by itself!
Time of Update: 2022-10-19
References:The use of subjective cognitive complaints for detecting mild cognitive impairment in older adults across cultural and linguistic groups: A comparison of the Cognitive Function Instrument to the Montreal Cognitive Assessment.
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AJNR: neuroimaging of retinal angiopathy with leukoencephalopathy and multisystem damage
Time of Update: 2022-10-19
A 30 mm diameter annular enhancement lesion located on the lateral left frontal horn, with multiple punctate magnetic sensitivity artifacts and diffusion inhibition in the center of the lesion, and peripheral extensive vasogenic edema with mass effect (a, FLAIR.
