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Brain-Liu Gang/Hu Qingmao team revealed the driving role of auxiliary motor areas in the alteration of brain-wide structural networks in patients with blepharospasm
Time of Update: 2022-10-20
Written by Liu Gang - Wang Sizhen, Fang YiyiEditor—Summer LeafBlepharospasm (BSP) is one of the most common types of dystonia, characterized by frequent, symmetrical, involuntary spasms of the eyelids
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FASEB J—Liu Yang's team found that antipsychotics caused vascular abnormalities in hematopoietic organs in experimental animals
Time of Update: 2022-10-20
" The study showed that antipsychotic drugs represented by haloperidol affected homeostasis hematopoiesis in mice and caused vascular malformations in hematopoietic organs including bone marrow, spleen, and liver, but had no effect on blood vessels of non-hematopoietic organs 。 Hematopoietic abnormalities and vasodilation caused by drugs such as haloperidol are reversible processes, and after timely discontinuation, the blood system and blood vessels can return to normal.
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Read | new drug options for anti-epileptic seizures
Time of Update: 2022-10-20
▌ Focal seizuresThe PERMIT study showed a significant reduction in monthly seizure frequency (P 104 weeks) addition of perampanel does not aggravate absence and myoclonic seizures, and that both 50 percent and 75 percent of response rates are stable during long-term treatment [9] (Figure 2).
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Migraine, what are the indications for preventive drug treatment?
Time of Update: 2022-10-20
*For medical professionals onlyDiagnose and treat big and small issues, and see what the guidelines say What are the diagnostic criteria for major diseases?What are the preferred treatment drugs and r
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【Nature】Stanford University implants "mini human brains" into mice, creating a new era of organoid research!
Time of Update: 2022-10-20
This article is the original of Translational Medicine Network, please indicate the source of reprinting Written by SophiaScientists want to use tiny brain-like structures grown from human stem cells, brain organoids, to study neurodegenerative and neuropsychiatric diseases in human development.
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Sangamo AAV has a long-lasting effect in the treatment of Fabry disease, and the global progress of AAV therapy for rare diseases is at a glance
Time of Update: 2022-10-20
com/article/releases/sangamo-therapeutics-announces-updated-preliminary-phase-1-2-data-in-fabry-disease-showing-continued-tolerability-and-sustained-elevated-%ce% b1-gal-a-enzyme-activity-in-nine-patients/——List of recent popular events——▼October 14,—— ▼October 18, the application and development trend of biopharmaceutical safety detection technologyFabry disease is a rare X-linked inherited lysosomal storage disorder caused by mutations in the α-galactosidase A gene (GLA), resulting in a lack of α-Gal A activity and inability to metabolize sphingosine trimerexin (Gb3) normally.
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Why is it useless to take painkillers for hand trauma? The Chinese team BMJ published the case
Time of Update: 2022-10-20
A recent case published in the British Medical Journal tells the story of a middle-aged man who accidentally hit his right hand at work and developed progressive diffuse pain with swelling and bruising.
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"Nature" blockbuster: "mouse body and human brain" chimeric model is born! Will neuroscience take a new leap?
Time of Update: 2022-10-20
Based on human stem cell culture technology, scientists have built brain organoids in vitro to study human brain development and neurological diseases.
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The Lancet: Subverting Perception! The largest meta-analysis to date suggests that adults with major depressive disorder with childhood trauma benefit from aggressive treatment
Time of Update: 2022-10-20
In addition, there was no significant difference in the improvement of depressive symptoms between adult depressive disorder patients with and without childhood trauma from baseline to acute treatment (g=0.
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How is status epilepticus handled? These 7 points need to be clear
Time of Update: 2022-10-20
*For medical professionals onlyThe focus is on stabilizing the patient's respiratory and circulatory stateStatus epilepticus (SE) refers to frequent recurrences of consciousness that do not fully recover between successive seizures, or that seizures do not stop on their own for more than 30 minutes.
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Raising more than $600 million in a year, Neumora uses data to drive precision treatments for brain diseases
Time of Update: 2022-10-20
Berns said the Series B funding rounds reflect Neumora's continued progress in building a best-in-class neuroscience company, including building a world-class team, expanding industry-leading data science and translational neuroscience platforms, and advancing an extensive and growing pipeline of seven research and development 。 Neumora was incubated by ARCH Venture Partners in 2019, and in October 2021, Neumora completed a $500 million Series A funding round led by ACH, moving out of stealth mode.
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Non-invasive electrical stimulation of the brain may improve memory in the elderly
Time of Update: 2022-10-20
Commenting on the potential to send specific types of noninvasive electrical stimulation to specific areas of the brain has the potential to improve working and long-term memory in older adults.
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Science—Analysis of neurogenesis and regeneration in Mexican salamanders using single-cell multiomics techniques
Time of Update: 2022-10-20
Written by Yang Si - Wang Sizhen, Fang YiyiEditor—Summer LeafThe Mexican salamander (Ambystoma mexicanum) is an amphibian that represents one of the closest living relatives to amniotic animals, i. e.
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Good Essay Collection Blood biomarkers in neurology
Time of Update: 2022-10-20
More natural, long-term studies are likely needed to evaluate the additional role of blood biomarkers beyond standard clinical practice and to directly assess the clinical benefits of early diagnosis and more accurate prognosis in everyday practice.
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Express The effect lasts for 23 months after discontinuation! Innovative Gene Therapy prepares to launch Phase 3 clinical trials
Time of Update: 2022-10-20
▲If you have any business needs, please long press to scan the QR code above, or▎WuXi AppTec content team editorSangamo Therapeutics announced the latest results of a Phase 1/2 clinical trial evaluating its gene therapy ST-920 for Fabry disease.
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Prognostic significance of biomarkers for head injury
Time of Update: 2022-10-20
This article is from the NEJM Journal Watch Prognostic Value of Biomarkers in Traumatic Brain Injury Biomarkers for the Prognostic Significance of Head Injury Reviewed by Jaime Toro, MDGFAP and UCH-L1 are predictors of functional recovery in patients with head injury (TBI).
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Neuron: Scientists reveal the neural mechanisms that induce social avoidance behavior after long-term withdrawal from analgesic addiction
Time of Update: 2022-10-20
024The images in the article are from referencesFigure 3: KOR reduces serotonin release and causes withdrawal-related social impairmentsummaryIn this paper, it was found that KOR activation after opioid withdrawal inhibits the release of serotonin in the NAc shell region, causing social avoidance behavior.
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"Nature" blockbuster: the perfect "combination" of the human-mouse brain! Ushering in a new era of organoid research
Time of Update: 2022-10-20
Today, Nature's blockbuster research finally solved this conundrum by transplanting brain-organoids into rats' developing brains, and finding that they can develop and mature normally, and partially integrate with the brain's neural circuits, truly becoming part of the brain.
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Cell Yang Daping reveals a new mechanism by which pain-receptor nerves regulate goblet cell mucus secretion to protect the intestinal mucosa
Time of Update: 2022-10-20
On October 14, 2022, Yang Daping from Harvard Medical School published a publication in Cell magazine titled Nociceptor neurons direct goblet cells via a CGRP-RAMP1 axis to drive mucus production and Article by Gut Barrier Protection.
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Nature | Human brain organoid cell fate regulator
Time of Update: 2022-10-20
The Gray Camp research group co-published a paper entitled Inferring and perturbing cell fate regulomes in human brain organoids, by establishing a Pando analysis framework that integrates multi-omics data and transcription factor binding site prediction.
