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Nature Neuroscience: Yang Tielin's team at Xi'an Jiaotong University reveals the causal relationship between brain image phenotype and the risk of psychiatric diseases
Time of Update: 2022-10-21
The study was based on large-scale genomic data and included 10 common psychiatric disorders (including ADHD, anorexia nervosa, anxiety, autism, bipolar disorder, depression, obsessive-compulsive disorder, post-traumatic stress disorder, schizophrenia, tics) and 587 key brain magnetic resonance imaging (MRI) structural phenotypes were evaluated for causality.
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AnnNeurol—Chen Wanjin/Fan Dongsheng's research group revealed that heterozygous mutations in the SerRS gene cause peroneal muscular atrophy
Time of Update: 2022-10-21
Written by He Jin - edited by Wang SizhenEditor—Summer LeafCharcot-Marie-Toothdisease (CMT) is the most common inherited peripheral neuropathy and is typically clinically characterized by adolescent o
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Acetylcholine receptor (AChR) antibody-positive myasthenia gravis, from antibody to complement
Time of Update: 2022-10-21
The antigen-antibody complex in the patient activates complement, leading to a cascade that attacks the postsynaptic membrane at the neuro-muscular junction, leading to clinical signs of skeletal muscle weakness.
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Breakthroughs have been made in the treatment of cerebral palsy, non-invasive spinal cord electrical and neuromodulation, and significantly improved motor function in children with cerebral palsy
Time of Update: 2022-10-21
co/ style="letter-spacing: normal;color: rgb(136, 136, 136);font-size: 12px;" _mstmutation="1" _istranslated="1"> open for reprinting, welcome to forward to Moments and WeChat groups Written byWang CongEditorWang DuoyuTypesettingWater into textCerebral Palsy (CP) is a non-progressive brain injury syndrome caused by multiple causes, characterized by central movement disorders and postural abnormalities.
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Xiao Lei's team at Fudan University revealed the circuit mechanism of dopamine type 1 receptors regulating anxiety behavior
Time of Update: 2022-10-21
Figure 1: Anxiolytic and anxiolytic effects of D1 receptors2Different types of neurons expressing D1 receptors regulate anxiety behaviorAcute activation by optogenetics or chronic activation of D1 receptor-positive neurons in the VTA brain region promoted the residence time of mice in the central region of the open field experiment, increasing the time of mice in the open arm, while chronic inhibition of the neuron caused anxiety-like behavior in mice.
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Is Aβ an effective target for the treatment of Alzheimer's disease? See what Harvard experts have to say!
Time of Update: 2022-10-21
00005), all key secondary endpoints also improved significantly (pThe author of this article Ying Yuyan*For medical professionals onlyAs society ages, the prevention and treatment of Alzheimer's disease (AD) has become more and more important, but despite the efforts of scientists, there is still no single treatment that can achieve the ultimate goal: to drastically reduce cognitive decline.
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NPJ Parkinsons Dis—Wang Xikim's team found that high PSQI is an independent risk factor for dyskinesia in Parkinson's disease
Time of Update: 2022-10-21
On September 29, 2022, the team of Professor Wang Xijin, Department of Neurology, Tongji Hospital affiliated to Tongji University, published the latest research results online in the journal NPJ Parkinson's Disease" High PSQI score is associated with the development of dyskinesia in Parkinson's disease", suggests Pittsburgh Sleep Quality Index, PSQI≥6) is an independent risk factor for dyskinesia in PD patients, and a predictive model for dyskinesia is constructed.
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Cell sub-issue: The mechanism of running improving Parkinson's disease was discovered for the first time!
Time of Update: 2022-10-21
For the first time, they discovered that regular running training can delay pathological progression and exercise performance in a mouse model of Parkinson's diseaseSpecifically, they found that regular running training slowed the spread of α-synuclein (α-syn) in the mouse brains and protected dopaminergic neurons in the substantia nigra.
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Following Ye Keqiang and other team Nature, Cell found new evidence that women are more likely to develop Alzheimer's
Time of Update: 2022-10-21
Original link: style="font-size: 10px;" _mstmutation="1" _istranslated="1"> style="margin-right: auto;margin-left: auto;outline: 0px;width: 30px;display: inline-block;">—END—The content is 【iNature】iNatureAlzheimer's disease (AD), commonly known as Alzheimer's disease, accounts for about 60-70% of all cases, is a clinical syndrome characterized by progressive deterioration of memory function and cognitive function, mostly in old age.
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Interview with Professor Wang Yong: Diagnosis and treatment strategies for postherpetic neuralgia (1)
Time of Update: 2022-10-21
Postherpetic neuralgia (PNH) is the most common chronic complication of herpes zoster (HZ), and patients with PHN often have unbearably severe pain that lasts for a long time and seriously affects dai
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When encountering headache patients, the diagnosis and treatment ideas are easy to handle
Time of Update: 2022-10-21
*For medical professionals onlyDiagnosis and treatment ideas should be clearAlthough headache is a common clinical symptom, it is not easy to diagnose because of the wide variety. It may result from a
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Nat Biomed Eng A new breakthrough in central nervous system gene therapy: a novel AAV variant crosses the blood-brain barrier
Time of Update: 2022-10-21
Some natural AAVs have been found to have some ability to cross the blood-brain barrier in mouse models, such as AAV9, AAVrh. 10, and AAVHSC 。 In May 2019, the US FDA approved Zolgensma, the first gene therapy drug using an intravenous AAV9 vector, for the treatment of children under 2 years of age with spinal muscular atrophy caused by the motor neuron survival gene 1 allele, but its price of up to $2.
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Cell Yan Yan/Jung-A.A. Woo/David E. Kang et al. revealed the molecular mechanism by which women are more susceptible to Alzheimer's disease
Time of Update: 2022-10-21
The novelty of our study resides in the discovery that excessive USP11 enzyme level in the brains of women causes the removal of too many ubiquitin tags from tau, which prevents the normal elimination of tau from nerve cells.
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Nature Neuroscience Tielin Yang/Yan Guo of Xi'an Jiaotong University reveal the causal relationship between brain image phenotype and psychiatric diseases
Time of Update: 2022-10-21
iNatureA mental disorder is a disorder that causes dysfunction of the brain, in which an individual is severely disturbed emotionally, cognitively, or behaviorally. Mental illness is reported to be a
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Nature: Human brain organoids are implanted into rat brains to improve human brain modeling capabilities
Time of Update: 2022-10-20
Link: style="color: rgb(136, 136, 136);font-size: 12px;letter-spacing: normal;" _mstmutation="1" _istranslated="1"> open for reprinting Welcome to forward to Moments and WeChat groups EditorWang DuoyuTypesettingWater into textHuman stem cell-cultured brain organoids are a promising platform for simulating human development and disease.
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The miracle of "brain in a jar": brain cells in a petri dish learned to play games by themselves!
Time of Update: 2022-10-20
▲ The neuron in the petri dish controls the racket and plays the Pong game (video source: Reference [1]).
▲ The neuron in the petri dish controls the racket and plays the Pong game (video source: Reference [1]).
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Nature Neuroscience: Solving the mystery of how the liver affects the progression of Alzheimer's disease!
Time of Update: 2022-10-20
Specifically, liver-derived apoE4 exacerbated brain amyloid pathology by impairing cerebrovascular function and synaptic plasticity, reducing memory and cognition in mice, and increasing blood vessel-related glial cell proliferation; Peripheral apoE3 works the opposite.
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5 major classifications of brain evoked potentials, an inventory of one article!
Time of Update: 2022-10-20
Motion evoked potentials Motor evoked potentials (MEPs) refer to the compound muscle action potentials recorded on the corresponding muscles by transcranial magnetic stimulation of motor cells of the cerebral cortex, spinal cord and peripheral nerve motor pathways, which can be used to understand central motor conduction function.
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The Lancet: Subverting Perception! The largest meta-analysis to date suggests that adults with major depressive disorder with childhood trauma benefit from aggressive treatment
Time of Update: 2022-10-20
In addition, there was no significant difference in the improvement of depressive symptoms between adult depressive disorder patients with and without childhood trauma from baseline to acute treatment (g=0.
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Got on the stage? Academician Wang Yutian revealed that excitatory transmitters directly bind to inhibitory receptors to enhance inhibitory currents
Time of Update: 2022-10-20
Click on the blue word to follow usIn the mammalian brain, the excitability of synapses is mainly maintained by glutamate by binding to ionic glutamate receptors, while the inhibitory properties of synapses are mainly mediated by γ-aminobutyric acid (GABA) by binding ionic GABAA receptors.
