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EditorWang Duoyu
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for simulating human development and disease.
However, organoids grown in vitro lack the various connections that exist in real organisms, which limits their maturation and prevents them from integrating
with other neural circuits that control behavior.
This in turn affects the ability of organoids to
mimic neuropsychiatric disorders with genetic complexity and behavioral characteristics.
Previous studies have attempted to implant human brain organoids into the brains of adult rats, but these cells do not fully mature
after implantation.
On October 12, 2022, the Sergiu Pașca lab at Stanford University published a paper in the journal Nature entitled "Maturation and circuit integration of transplanted human cortical" Research paper
by organoids.
The study found that human stem cell-derived brain-like tissue could integrate with the brains of newborn rats and also affect rat behavior
.
The findings may improve our ability to
construct practical models of neuropsychiatric disorders in humans.
In this study, the team implanted human brain organoids into the somatosensory cortex of the newborn rat brain, the area of the brain responsible for receiving and processing sensory information from the whole body, including touch
.
Human neurons grown from human stem cells were transplanted into rat brains (right) more fully
than in a dish (left) They found that the brain organoid matured and partially integrated with neural circuits.
And functional in rat
brains.
This integration allowed the researchers to establish a correlation between human cell activity and animal learned behavior, demonstrating that implanted neurons can regulate neuronal activity in rats and induce reward-seeking behavior
.
A human brain organ (bright green on the left) was transplanted into the brain of a newborn rat, creating a hybrid brain in which neurons were interconnected
In addition, a group of neurons in this organoid showed signs of activity when the researchers turned the rat's whiskers, Indicates that the implanted neurons can respond to
sensory stimuli.
The team also found that when implanting brain organoids derived from cells from three patients with Timothy Syndrome, a serious genetic disorder linked to heart problems, specific neuronal defects were highlighted, suggesting that the implantation technique could reveal previously unknown disease features
.
The research team says the technology could serve as a powerful resource to complement laboratory research
on human brain development and disease.
Further research may allow us to use patient-derived cells to unravel otherwise unknown disease features
.
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