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Written byWang Cong
EditorWang Duoyu
TypesettingWater into text
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It is also a common movement disorder in children, affecting about 15-40 per 10,000 newborns, which leads to more than 10,000 births of children with cerebral palsy each year, and there are currently 17 million people with
cerebral palsy worldwide.
However, until now, there are no methods or drugs
that can effectively prevent or treat cerebral palsy.
Often, children with cerebral palsy can only be treated with invasive surgery, which reduces spasms in the short term, but in the long term they may negatively affect functional changes, especially in growing children
.
Without intervention, the dysfunctional synaptic connections of children with cerebral palsy will be further aggravated, resulting in neuromuscular spasm, motor balance disorders, poor coordination and other problems
.
On October 5, 2022, researchers from SpineX published a paper in the journal Nature Communications titled : A pilot study combining noninvasive spinal neuromodulation and activity-based neurorehabilitation therapy in children with cerebral palsy
.
The paper presents the results of the first-in-human study of SCiP, a non-surgical, non-invasive device developed by SpineX in the treatment of children with cerebral palsy, which significantly improved autonomic sensorimotor function
in 16 children of different ages and severity.
The team completed a single-arm, unblinded clinical pilot study to investigate whether interventions combined with noninvasive spinal neuromodulation in neurorehabilitation in children with cerebral palsy could improve voluntary sensorimotor function, as assessed by GMFM-88 (GMFM-88 is recognized as the most widely used scale for gross motor function in children with cerebral palsy.
)
The research team recruited 16 children with confirmed cerebral palsy and whose GMFM-88 gross motor function scale for children with cerebral palsy was classified as I-V and received the same intervention (2 times/week for 8 weeks) to correct dysfunction of the connection between the spinal cord and the spinal cord network using normally developing proprioception
.
The results showed that these interventions were associated with clinically and statistically significant improvements in GMFM-88 scores for all children with cerebral palsy, meeting pre-specified primary endpoints, and no serious adverse events
observed.
Overall, these findings suggest that a combination of spinal cord neuromodulation and neurorehabilitation is associated
with a significant improvement in GMFM-88 scores and improvements in clinical autonomic sensorimotor function in children with cerebral palsy.
In addition, improvements in these functions were associated
with improvements in quality of life for parents of children with cerebral palsy.
SpineX is a clinical-stage medical technology company whose non-invasive spinal cord electrical neuromodulation device SCiP has received breakthrough device designation
from the US FDA by providing percutaneous spinal nerve stimulation for the treatment of neurological dysfunction in children with cerebral palsy.
This is the company's second FDA breakthrough device certification
after SCONE.
SCONE, also a non-invasive electro-spinal neuromodulation device for the treatment of urinary incontinence due to stroke, spinal cord injury or multiple sclerosis, was successfully developed
in a multicenter clinical trial.
Reference link: https://spinex.
co/ style="letter-spacing: normal;color: rgb(136, 136, 136);font-size: 12px;" _mstmutation="1" _istranslated="1">
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