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Wu Qi's team at Baylor College of Medicine in the United States reported a novel neural circuit regulation mechanism and targeted combination therapy for the co-occurrence of obesity and anxiety and depression
Time of Update: 2021-03-26
com/tags/%E6%8A%91%E9%83%81%E7%97%87/" target="_blank">depressionMore importantly, we found that after correcting the defects in the neural circuit to a normal state, the anxiety and depression caused by a high-fat diet can be effectively eliminated, and then the food intake and weight can be significantly reduced.
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Sci Adv | Research reveals the control effect of autophagy pathways regulating addictive drugs
Time of Update: 2021-03-25
Studies have found that these autophagy inhibitors can indeed inhibit the mental stimulation and rewarding behavior of cocaine, can also inhibit the accumulation of dopamine in the NAc brain area caused by cocaine, and can also make presynaptic D2R more stable.
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China's first new class 1 drug for Ebomycin breast cancer has been approved for sale
Time of Update: 2021-03-25
Recently, Li’s large pharmaceutical company announced that its subsidiary, China Oncology Medical, has obtained NMPA approval for clinical trial applications to conduct multi-center, randomized, double-blind, and parallel grouping of Socazolimab combined with chemotherapy for the first-line treatment of diffuse small cell lung cancer.
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AstraZeneca's targeted drug Tagrisso India is approved for adjuvant treatment of early EG...
Time of Update: 2021-03-25
AstraZeneca India recently announced that the targeted anticancer drug Tagrisso (Chinese trade name: Teresa, generic name: osimertinib, osimertinib) has been approved in India: for tumors carrying epidermal growth factor receptors (EGFR) mutated non-small cell lung cancer (NSCLC) patients with adjuvant treatment after complete tumor resection.
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Rongchang bio's first original innovative drug tai ai ® approved to open the systemic lupus erythematosus "double target ...
Time of Update: 2021-03-25
love Thai ® is approved for the treatment of SLE situation has brought new changes for Clinicians will bring more and better weapons to achieve the target treatment of lupus, and bring new hope for patients to maintain low recurrence of the disease and reduce or even no use of glucocorticoids.
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Is "Inception" coming true?
Time of Update: 2021-03-25
In this study, in order to realize the "two-way communication" with the dreamers—both asking and answering questions to the dreamers, the researchers first trained the volunteers to enter the state of "lucid dreaming".
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Happy experiences promote learning? Scientists find that past experiences reshape neural circuits and affect learning ability
Time of Update: 2021-03-25
Researchers used multiple behavioral experiments to further discover the role of LH inhibitory neurons in the learning process: in the first experiment, sound-electric shock paired fear memory training In the process, the light-inhibition of lateral hypothalamic (LH) inhibitory neurons while giving sound does not affect the acquisition of fear memory in rats, which is no different from the performance of normal rats.
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Prenatal music, the more you listen, the smarter?
Time of Update: 2021-03-25
The study used genetic mutation-induced deafness mouse models and found that the excitatory and inhibitory input between the auditory cortical sublaminar neurons and the 5/6th layer neurons of the cortex increased in pups with abnormal hearing around the 6th day after birth.
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A "redemption" and a $1.38 billion transaction of "slimming" Takeda...
Time of Update: 2021-03-25
In a statement at the time, Emiliangelo Ratti, head of the therapeutic field of Takeda Neuroscience, stated that Ovid has been focusing on the development of treatments for rare neurological diseases and the development of central nervous system drugs.
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Top 10 most expensive drugs in the world in 2021
Time of Update: 2021-03-25
Evrysdi, a small molecule drug approved in 2020, has an annual treatment cost of more than US$300,000 at the highest recommended dose (5mg, 2 years and older or weight over 20kg, qd).
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Placental stem cells can be launched to improve the health of patients!
Time of Update: 2021-03-25
Recently, the US FDA approved the world's first human clinical trial using stem cells to treat spina bifida before birth, and this trial uses placental-derived mesenchymal stem cells.
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Science | "Pain" What you "pain" is also the same as "fear"-how do mice feel each other's pain or fear?
Time of Update: 2021-03-25
The author used reporter mice generated by crossing FosCreERT2 (TRAP2) mice with Ai14-tdTomato strains to identify the types of neurons activated during the interaction, and found that the brain regions of BY mice related to empathy and motivation previously reported Such as ACC and NAc, as well as areas related to pain transmission, such as the thalamus, central amygdala, and midbrain peri-aqueduct gray matter are activated.
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Another first copy of Dongyang Sunshine "Entacapone Film" is about to be approved
Time of Update: 2021-03-25
This time, Dongyang Sunshine's entacapone generic drug's listing application has entered the administrative examination and approval stage first, and it is expected to become the first imitation of this product in China.
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Neuron | Song Hongjun's team reveals the basic laws of the development and formation of the hypothalamic nucleus
Time of Update: 2021-03-25
The author was surprised to find that the glutamatergic ventromedial nucleus neurons and the gamma-aminobutyric acid nodular nucleus neurons originated from the same precursor cell area in the embryonic stage, and named them pVMH (progenitor domain of ventromedial hypothalamus).
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PNAS | Xu Han's team reveals a new neural circuit mechanism for social behavior regulation
Time of Update: 2021-03-25
In order to answer the above scientific questions, members of the research team used Fiber Photometry technology to first detect the activities of different neuron types in the basal forebrain of mice during social interaction, and found that the somatostatin (SST) positive inhibitory neurons occurred in social interaction.
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6 billion oseltamivir or competitor of welcome drug
Time of Update: 2021-03-25
Zhongsheng Pharmaceutical's 2020 semi-annual report shows that ZSP1273 tablets are the first domestic small molecule RNA polymerase inhibitor to treat influenza A that has completed a phase II clinical trial-a new anti-influenza drug with a brand-new target.
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The first phase II "sound and light" therapy for Alzheimer's has positive results
Time of Update: 2021-03-25
The therapy achieved positive results in phase II clinical trials, which significantly improved the memory, cognition, and daily functions of AD patients, and reduced brain atrophy and brain volume loss in patients with mild to moderate AD.
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A randomized double-blind crossover test: drinking coffee does not affect sleep, but it changes the structure of the brain...
Time of Update: 2021-03-25
Recently, in a new study published in "Cerebral Cortex", a research team led by the University of Basel in Switzerland found through a randomized double-blind crossover test that regular coffee (with caffeine) does not affect sleep quality.
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Nat Cell Biol | Uncovering the Causes of Anorexia in Cancer Patients
Time of Update: 2021-03-25
The authors found that Lgr3 mutation can reverse tumor anorexia, and Dilp8 overexpression can lead to reduced food intake, indicating that Dilp8-Lgr3 signaling can regulate tumor anorexia behavior.
These results indicate that tumor-derived INSL3 is related to anorexia in human pancreatic cancer.
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Science Journal: Multi-faceted IL-17 Controls Short-term Memory
Time of Update: 2021-03-25
Now scientists have discovered that immune cells that enter the center release inflammatory factors that can participate in the physiological functions of the brain.
, Meningeal γδ T cell–derived IL-17 controls synaptic plasticity and short-term memory, Sci.
