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Why Stumble Around After Being Drunk—Professor Zhang Li reveals that cerebellar astrocytes mediate dyskinesia in alcoholism
Time of Update: 2021-03-26
After specifically knocking out ALDH2 on astrocytes, the concentration of acetaldehyde in peripheral and cerebellar tissues was no different from that of normal mice, but the concentration of alcohol metabolite acetate in peripheral and cerebellar tissues was significantly reduced.
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IL-4 improves stress tolerance and reduces depression
Time of Update: 2021-03-26
) Pro-inflammatory cytokines in mental diseases (Document 1) Since pro-inflammatory cytokines are involved in inducing mental diseases, cytokines that inhibit inflammation, such as Can IL-4 enhance the body's tolerance to stress and resist the occurrence of depression?
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JNNP: The effect of Erenumab on functional outcomes in patients with paroxysmal migraine: the results of the LIBERTY study
Time of Update: 2021-03-26
Compared with placebo, Erenumab significantly improved physical impairment (PI) and daily activity (EA) scores (treatment difference (TD) (95% CI) migraine effect on physical function (MPFID)-PI: −3.
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JCEM: The relationship between prenatal depression and gestational diabetes risk, adverse pregnancy outcomes and postpartum quality of life
Time of Update: 2021-03-26
The study aims to clarify the effects of depression on the pregnancy outcome and postpartum of women with gestational diabetes (GDM) and normal glucose tolerance (NGT).
Compared with non-depressed NGT women, NGT women with depressive symptoms have a higher induction rate and lower postpartum quality of life .
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Li Huawei/Shu Yilai team developed CRISPR/Cas9 gene editing to prevent sensorineural hearing loss
Time of Update: 2021-03-26
On March 22, 2021, Professor Li Huawei from the Eye, Ear, Nose and Throat Hospital Affiliated to Fudan University and a research team from Shu Yilai published a research paper Prevention of acquired sensorineural hearing loss in mice by in vivo Htra2 gene editing in Genome Biology.
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JACC: Does it prevent dementia? Then lower your blood pressure first!
Time of Update: 2021-03-26
In summary, among asymptomatic middle-aged people, cardiovascular risk is related to low brain metabolism, and hypertension is the most strongly associated factor in modifiable CVRF with cognitive decline.
Cardiovascular risk is related to low brain metabolism, among which hypertension is the strongest factor associated with cognitive decline in modifiable CVRF.
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Cell Death Differ: The natural compound Withaferin A plays a neuroprotective effect on Parkinson's disease by mediating the DJ1-Nrf2-STING pathway
Time of Update: 2021-03-26
The effect of Withaferin A on the expression of SNc gene in PD miceAll in all, the results of this study reveal the multi-faceted role of WA in neuroprotection, and WA may be a potential drug candidate for PD treatment.
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PNAS: Infant attention is related to the frontal cortex
Time of Update: 2021-03-26
The behavior of all infants in the study has a strong validity, accompanied by the participation of part of the brain network that supports adult attention, especially the frontal cortex.
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Intracranial hemorrhage, when should hemostatic agents be used? Who can use it?
Time of Update: 2021-03-26
1016/S0140-6736(18)31033-X] published in Lancet in 2018 is an international multi-center, placebo, randomized controlled Phase 3 clinical study that explores "intracranial hemorrhage patients" Whether tranexamic acid treatment in the hyperacute phase can reduce hematoma enlargement and improve patient prognosis", the main clinical outcome: 90-day neurological function (mRS).
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Mo Wei's team at Xiamen University discovered the key role of epigenetics in cerebellar morphogenesis
Time of Update: 2021-03-26
At the peak of cerebellar development (from P7 to P10), GC migration requires genes that are down-regulated in this time window and is completely inhibited by the Nfix-Setdb1 repressor complex.
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JAMA Pediatr: The effect of hypertension during pregnancy on the neurodevelopmental outcome of offspring
Time of Update: 2021-03-26
Recently, researchers investigated hypertension in pregnancy Relationship with autism spectrum disorder, attention deficit/hyperactivity disorder and intellectual disability in the offspring, and to investigate its impact on the overall cognitive performance of the offspring.
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Neurology: Beware of air pollution, the risk of dementia after exposure to PM2.5 increases significantly in old age
Time of Update: 2021-03-26
5 Associated With Gray Matter Atrophy Reflecting Increased Alzheimer Risk in Older Women neurology.
5 Associated With Gray Matter Atrophy Reflecting Increased Alzheimer Risk in Older Women neurology.
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J Alzheimers Dis: Exercise can promote blood flow in the brain
Time of Update: 2021-03-26
Journal of Alzheimer's Disease, 2021 One-Year Aerobic Exercise Reduced Carotid Arterial Stiffness and Increased Cerebral Blood Flow in Amnestic Mild Cognitive Impairment.
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Stroke: The influence of delirium and its subtypes on stroke outcome
Time of Update: 2021-03-26
Although delirium is common in stroke patients, there is a lack of studies evaluating the correlation between clinical subtypes of delirium and functional outcomes and death.
The main outcome of the study was functional dependence or death at 90 days between delirium patients and non-delirium patients and subtypes (modified Rankin scale> 2).
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Nat Commun: Intraciliary transport decreases with age, impairing sensation and metabolism
Time of Update: 2021-03-26
They reported that due to the reduction of IFT components regulated by daf-19/RFX , the intrafellar transport (IFT) of sensory neurons in elderly nematodes was impaired.
The study found that up - regulation of daf-19/RFX can effectively enhance IFT , sensory perception, AMPK activity and autophagy, and promote metabolic homeostasis and longevity .
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The latest data! Can this DMD gene therapy, which has been suspended for more than a year, effectively improve the patient's condition 丨 Yimai Meng broke the news
Time of Update: 2021-03-26
MedClub broke the news March 25, 2021/eMedClub News/--Recently, at the MDA virtual clinical and scientific conference, Solid announced the latest clinical research results for Duchenne muscular dystrophy (DMD).
Participants who successfully registered for the Shanghai 2021 BPIT conference will receive a limited edition of "CAR-T Cell Therapy Industry Research Report" 2021.
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JAMA Neurol: Incidental discovery rate of brain MRI in healthy children and its clinical significance
Time of Update: 2021-03-26
Researchers in children recently investigated the accidental discovery rate of brain MRI in non-clinical pediatric population, focusing on the accidental discovery rate of recommended clinical referrals.
Recently, researchers investigated the accidental discovery rate of brain MRI in non-clinical pediatric population, focusing on the accidental discovery rate of recommended clinical referrals.
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BMJ: What about depression in Alzheimer's patients? Pet companions or other non-pharmacological interventions are worth considering
Time of Update: 2021-03-26
The results of the study showed that compared with conventional care, there are 7 interventions that are related to significantly reducing the depressive symptoms of dementia patients, including: cognitive stimulation, cognitive stimulation combined with cholinesterase inhibitors, massage and touch therapy, multidisciplinary care, Occupational therapy, exercise combined with social and cognitive stimulation and recall therapy.
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What is the best assessment method for acute stroke? Talk about your thoughts
Time of Update: 2021-03-26
This debate is not about the increasing number of endovascular treatments and the discussion of no large vessel occlusion, but to find a practical, effective, economical, and the best acute brain in community hospitals that can be implemented on a global scale.
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MONEAD study: Is it safer for expectant mothers to choose these two anti-epileptic drugs? 丨AAN2021
Time of Update: 2021-03-26
➤The ratio of the maximum blood concentration of anti-epileptic drugs in the third trimester of pregnancy has no significant correlation with the general conceptual ability scores of children born to pregnant women with epilepsy after correction.
