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Dementia is an important global health challenge today, so far there is no effective strategy to reverse or cure dementia.
Dementia is an important global health challenge today, so far there is no effective strategy to reverse or cure dementia.
Researchers have found that middle-aged hypertension can significantly increase the risk of cognitive impairment.
In fact, as early as more than 20 years ago, some researchers have observed the effect of antihypertensive treatment on preventing the most common dementia-Alzheimer's disease (AD, Alzheimer's disease).
The effect of antihypertensive treatment on preventing the most common dementia-Alzheimer's disease (AD, Alzheimer's disease).
medsci.
This study aims to determine the effects of cardiovascular risk factors (CVRFs) and subclinical arteriosclerosis (SCAS) on brain metabolism.
The study included 547 middle-aged participants (50±4 years old, 82% male) who had been proven to have subclinical arteriosclerosis but had no clinical manifestations in the PESA trial.
The results showed that the total brain FDG intake was negatively correlated with the 30-year Framingham risk score (FRS, which stands for cardiac risk score) (β=-0.
Whole brain FDG intake was negatively correlated with the 30-year Framingham risk score (FRS, which stands for cardiac risk score) (β=-0.
The brain areas most strongly affected by hypermetabolism associated with 30-year FRS, hypertension, and carotid plaque burden are the paratemporal area (corner, superior margin, and inferior/middle temporal gyrus) and the cingulate gyrus.
The researchers pointed out that the results suggest that even in the absence of clinical symptoms, retro-arterial sclerosis and CVRFs, especially hypertension, have affected the metabolism of the brain.
Even in the absence of clinical symptoms, retro-arteriosclerosis and CVRFs, especially high blood pressure, have affected the metabolism of the brain.
Cardiovascular risk is related to low cerebral metabolism, among which hypertension is the strongest factor associated with cognitive decline in modifiable CVRF.
references:
Cortes-Canteli M, et al.
elsevier.
com/reader/sd/pii/S0735109720381298?token=8AB92DF4ED3E055A2923AF161197C26667FC09468F857026513F58DD6C79B591730956D27E8D15D0F48572546FF8236B" target="_blank" rel="noopener">Subclinical Atherosclerosis and Brain Metabolism in Middle-Aged Individuals: The PESA Study.
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