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The BMI1 gene prevents Alzheimer’s disease by inhibiting the production of four-stranded DNA in neurons
Time of Update: 2021-03-27
In this Nature Communications paper, the research team found that G-quadruplex structures accumulate in the brain neurons of Alzheimer's patients, but not in the brains of healthy elderly people.
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THALES study subgroup analysis: For stroke patients with arterial stenosis, ticagrelor combined with aspirin may be a better treatment option
Time of Update: 2021-03-27
This exploratory analysis of the THALES study included a total of 2351 patients with ipsilateral stenosis ≥30% with or without aortic arch plaque thickness ≥4 mm, and found that ticagrelor combined with aspirin significantly reduced stroke or The risk of death is 27%, and the NNT is only 34.
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University of Electronic Science and Technology of China You Zili/Chen Huafu discovers the unique role of microglia in depression
Time of Update: 2021-03-27
Adult neurogenesis in the iNature hippocampal dentate gyrus is regulated by a specific microglia cell population and is functionally involved in the behavioral response to stress.
The study found that interleukin 4 (IL4 ) Driven microglia are characterized by high expression of Arg1, which is essential for maintaining hippocampal neurogenesis and stress resistance.
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Nat Metab Cover Article | Zhang Li's team reveals the important mechanism of drunkenness: the cause of drunkenness is not in wine, "in vinegar"
Time of Update: 2021-03-27
In this work, the researchers used highly sensitive RNA in situ hybridization (RNAscope) and other biochemical techniques combined with cell-specific ALDH2 knockout mice to verify that the key enzyme of alcohol metabolism in the central nervous system --- ALDH2 is mainly in It is expressed in astrocytes in the cerebellar cortex, and similar expression characteristics are also observed in other brain regions.
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Secondary analysis of the RACECA study: Can patients with acute large vessel occlusion with RACE ≥ 5 be directly transferred to an endovascular treatment center for treatment? 丨ISC2021
Time of Update: 2021-03-27
Yimaitong compiled from: Secondary Analysis of the Racecat Trial: Benefit of Direct Transfer to an Endovascular Stroke Center According to the Presence of Large Vessel Occlusion and the Transfer Time to the Endovascular Center.
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Professor You Zili reveals the molecular mechanism of immune cells causing nerve regeneration
Time of Update: 2021-03-27
However, under pathological conditions such as depression, anxiety, and Alzheimer's disease, the "ecological environment" of nerve regeneration in the hippocampal DG area becomes disordered, which directly causes a decrease in the number of new neurons.
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Neuron | Injury causes an increase in the ratio of NMN/NAD+ in axons to activate axonal degeneration executioner SARM1
Time of Update: 2021-03-27
SARM1 is a metabolic sensor activated by an increased NMN/ The NAD+ ratio to trigger axon degeneration indicates that the accumulation of the substrate NMN caused by the degradation of NMNAT2 and the reduction of the product NAD+ jointly regulate the function of SARM1.
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Borrowing CT perfusion imaging, can thrombolysis in patients with stroke beyond the time window? 丨ISC2021
Time of Update: 2021-03-27
The main results were demographic characteristics, time from onset to treatment (OTT), NIHSS scores at admission and 24 hours, imaging findings, clinical status at discharge, and bleeding complications.
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Please stop overdrawing your sleep | World Sleep Day Special
Time of Update: 2021-03-27
In order to confirm that the drug-induced findings are related to actual sleep deprivation, the researchers conducted a test and found that zebrafish that were forced to stay awake had a longer sleep time the next day, and during restorative sleep, their The brain shows enhanced galanin activity.
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"Everything goes wrong" has a neurobiological explanation and is related to the amygdala
Time of Update: 2021-03-27
[3] (Summary at the end of the article) Researchers believe that how the human brain evaluates short-term negative stimuli (such as coffee spills) may affect its long-term mental health.
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When a patient with schizophrenia develops tardive dyskinesia, life becomes like this!
Time of Update: 2021-03-27
In the two studies of ARM-TD and AIM-TD, all doses of deuterium tetrabenazine scores improved> 2 points after 12 weeks of treatment, which has important clinical significance [4,5].
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Hypertension, diabetes, obesity... the impact of cardiovascular risk factors throughout life on cognition in later life
Time of Update: 2021-03-27
A linear mixed model was used to determine the association of early, middle, and late adult CVRFs with declines in overall cognition (modified mini mental status examination (3MS)) and processing speed (digital sign substitution test (DSST)) in later life.
Cardiovascular Risk Factors Across the Life Course and Cognitive Decline: <b>A Pooled Cohort Study.
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SHRINE summary analysis: Is direct thrombectomy not inferior to bridging thrombectomy? 丨ISC2021
Time of Update: 2021-03-27
The current pooled analysis mainly focuses on the data of two of the trials, aiming to evaluate the non-inferiority of EVT alone and bridging therapy in patients with large vessel occlusive stroke who are eligible for IVT.
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Neurology: Long-term effects of cholinesterase inhibitors on cognitive decline and mortality
Time of Update: 2021-03-26
Recently, a research article was published in Neurology, an authoritative journal in the field of neurology, which aims to determine whether cholinesterase inhibitors (ChEIs) are related to the slowing down of cognitive function in Alzheimer’s dementia, severe dementia or death Related to the risk reduction.
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Eur Heart J: Association between prophylactic ACEi treatment and overall survival in patients with Duchenne muscular dystrophy
Time of Update: 2021-03-26
do?w=%E5%BF%83%E8%A1%80%E7%AE%A1">heart blood vessels magazine field authority Eur Heart published a research article on J, the study was designed to evaluate the prevention of angiotensin converting enzyme inhibitors (ACEi) therapy on survival in patients with Duchenne muscular dystrophy (DMD) of .
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I was born with a stroke and lacked a quarter of the cerebral cortex, but I lived a normal life for 22 years... The Lancet sub-Journal reported a rare brain "remodeling"
Time of Update: 2021-03-26
” Screenshot source: The awkward right hand on The Lancet Neurology baseball field first noticed Daniel’s body abnormality.
" Daniel's MRI scan showed that a severe stroke during his infancy caused injuries to both sides of his brain.
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Nature | Xu Huaqiang/Zhang Yan/Jiang Yi collaborated to reveal the drug action of the neurotransmitter serotonin receptor and the molecular mechanism of phospholipid regulation
Time of Update: 2021-03-26
This work reveals how phospholipid PI4P (PtdIns4P) and cholesterol regulate receptor functions, and the molecular mechanism of how the drug Aripiprazole recognizes serotonin receptors.
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Nature | Biological Clock and Dawn Phenomenon——The Circadian Regulation Mechanism of Insulin Sensitivity
Time of Update: 2021-03-26
On March 24, 2021, Professor Sun Zheng from Baylor College of Medicine and Professor Chen Li from Qilu Hospital of Shandong University jointly published a research paper entitled REV-ERB in GABAergic neurons controls diurnal hepatic insulin sensitivity in Nature, reporting on the hypothalamic optic chiasm The REV-ERB gene of GABA neurons in the nucleus (SCN) region controls the circadian rhythm of insulin suppression of liver gluconeogenesis.
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There is a "zombie gene" in the human brain, and it becomes active only after death
Time of Update: 2021-03-26
The research was published in the journal "Scientific Reports" with the title "Selective time-dependent changes in activity and cell-specific gene expression in human postmortem brain".
These "zombie genes"-those genes whose expression increases in the post-mortem interval-are a characteristic of the cell.
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Neurology: 200,000 big data research: After brain trauma, most people's long-term sleep quality is worrying
Time of Update: 2021-03-26
0000000000011656" target="_blank" rel="noopener">Traumatic Brain Injury and Incidence Risk of Sleep Disorders in Nearly 200,000 US Veterans neurology.
0000000000011656" target="_blank" rel="noopener">Traumatic Brain Injury and Incidence Risk of Sleep Disorders in Nearly 200,000 US Veterans neurology.
