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The traditional theory is that the brain is an immune-exempt organ, and there are very few inflammatory cells.
But now this view has been broken.
For example, the dura mater is the central immune cell assembly area.
In addition, in an inflammatory state, the blood-brain barrier will "explore" peripheral immune cells to enter the brain.
Previous studies have mostly focused on immune cells, inflammation of the nervous system caused by inflammatory factors, and mental diseases such as depression.
Now scientists have discovered that immune cells that enter the center release inflammatory factors that can participate in the physiological functions of the brain.
Science Immunology published an article by scientists from Portugal, France, Germany, and the United Kingdom, Meningeal γδ T cell–derived IL-17 controls synaptic plasticity and short-term memory, expounding the novelty of IL-17, an important pathogenic factor for autoimmune diseases Function to control short-term memory.
The authors of the study summary found that non-inflammatory IL-17 produced by γδ T that resides in the dura during embryonic development can improve cognition.
In the absence of γδ T or IL-17, the short-term memory of mice is impaired.
IL-17 can increase the production of BDNF by glial cells.
If BDNF is provided exogenously, it can rescue the synaptic and behavioral performance of IL-17-deficient mice.
This article is a further push for neuroimmunity, expounding the regulation of brain function by immune cells and their release of cytokines.
Main findings 1.
γδ T from embryos infiltrates the dura mater after birth.2.
Compared with other CD4+ cells and CD8+ T cells, γδ T is biased to produce IL-17.
3.
Dural homeostasis does not depend on inflammatory signals.
4.
IL-17 produced by γδ T is necessary for short-term memory.
5.
In short-term memory tasks, IL-17 regulates synaptic plasticity and AMPA/NMDA ratio.
6.
IL-17 promotes the production of glial cells.
BDNF360 Comments: The human body is a complex and perfectly regulated network, which regulates each other between nerve and immunity.
For more research details, please read the original reference Ribeiro et al.
, Meningeal γδ T cell–derived IL-17 controls synaptic plasticity and short-term memory, Sci.
Immunol.
4, eaay5199 (2019)
But now this view has been broken.
For example, the dura mater is the central immune cell assembly area.
In addition, in an inflammatory state, the blood-brain barrier will "explore" peripheral immune cells to enter the brain.
Previous studies have mostly focused on immune cells, inflammation of the nervous system caused by inflammatory factors, and mental diseases such as depression.
Now scientists have discovered that immune cells that enter the center release inflammatory factors that can participate in the physiological functions of the brain.
Science Immunology published an article by scientists from Portugal, France, Germany, and the United Kingdom, Meningeal γδ T cell–derived IL-17 controls synaptic plasticity and short-term memory, expounding the novelty of IL-17, an important pathogenic factor for autoimmune diseases Function to control short-term memory.
The authors of the study summary found that non-inflammatory IL-17 produced by γδ T that resides in the dura during embryonic development can improve cognition.
In the absence of γδ T or IL-17, the short-term memory of mice is impaired.
IL-17 can increase the production of BDNF by glial cells.
If BDNF is provided exogenously, it can rescue the synaptic and behavioral performance of IL-17-deficient mice.
This article is a further push for neuroimmunity, expounding the regulation of brain function by immune cells and their release of cytokines.
Main findings 1.
γδ T from embryos infiltrates the dura mater after birth.2.
Compared with other CD4+ cells and CD8+ T cells, γδ T is biased to produce IL-17.
3.
Dural homeostasis does not depend on inflammatory signals.
4.
IL-17 produced by γδ T is necessary for short-term memory.
5.
In short-term memory tasks, IL-17 regulates synaptic plasticity and AMPA/NMDA ratio.
6.
IL-17 promotes the production of glial cells.
BDNF360 Comments: The human body is a complex and perfectly regulated network, which regulates each other between nerve and immunity.
For more research details, please read the original reference Ribeiro et al.
, Meningeal γδ T cell–derived IL-17 controls synaptic plasticity and short-term memory, Sci.
Immunol.
4, eaay5199 (2019)
