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JNNP: C9orf72 repeated expansion of the early life spirit characteristics of carriers
Time of Update: 2021-05-21
This article studies the clinical features of bvFTD syndrome, as well as the patient's subtle personality characteristics and early mental symptoms in life.
This article is the first in-depth study of biographical interviews of bvFTD patients with C9orf72RE, revealing that subtle personality traits may exist early in life.
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Neurology: cardiac sympathetic neuroimaging, which can reflect dementia with Lewy bodies
Time of Update: 2021-05-21
Cardiac mIBG as a diagnostic marker of DLB has been confirmed, with good sensitivity (70%) and specificity (90%), but there are far fewer studies on the mild cognitive impairment stage (MCI-LB).
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Neurology: The age and mode of onset of Alzheimer's are closely related to clinical manifestations!
Time of Update: 2021-05-21
It aims to assess the impact of the estimated age of onset, APOE genotype and their interactions on standardized clinical, cognitive, and pathological results in the National Alzheimer's Coordinating Center (NACC) database.
abstract" target="_blank" rel="noopener">Age-of-Onset and APOE-Related Heterogeneity in Pathologically Confirmed Sporadic Alzheimer Disease.
abstract" target="_blank" rel="noopener">Age-of-Onset and APOE-Related Heterogeneity in Pathologically Confirmed Sporadic Alzheimer Disease.
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The speed of "mind typing" is close to that of mobile phone typing!
Time of Update: 2021-05-21
, for the first time, the movement of handwritten letters is decoded from brain nerve signals, so that the writing movement in the mind of paralyzed people can be converted into screen in real time On the text.
Finally, the research subjects can use this brain-computer interface to write at a speed of 90 per minute.
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Stroke: Ethnic differences in high carotid artery stenosis
Time of Update: 2021-05-21
Although they have more adverse cardiovascular risk factors, the prevalence of high-grade carotid stenosis in blacks and Hispanics is lower than that of whites.
Although they have more adverse cardiovascular risk factors, the prevalence of high-grade carotid stenosis in blacks and Hispanics is lower than that of whites.
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Stroke: The relationship between blood-based cardiac biomarkers and cognitive decline, cerebrovascular disease, and the risk of clinical events
Time of Update: 2021-05-21
Researchers aim to evaluate blood-based cardiac biomarkers (NT-proBNP, hs-cTnT and GDF-15) and cognitive decline, The relationship between sudden cerebrovascular disease, vascular events and mortality.
Higher levels of blood-based cardiac biomarkers are associated with decreased memory and the risk of vascular events and death.
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Crit Care: Track of Depressive Symptoms in Sepsis Survivors
Time of Update: 2021-05-21
It can be seen that in the first year after ICU discharge, sepsis survivors showed three different trajectories of depressive symptoms.
In the first year after ICU discharge, sepsis survivors showed three different trajectories of depressive symptoms.
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Alzheimer's&Dementia: Inflammation and genetic factors may increase the risk of dementia in the elderly with underlying diseases
Time of Update: 2021-05-21
Similarly, since the effect of lipoprotein E gene variants (APOE ε4) on the risk of dementia is well known, inflammation is one of the factors related to specific frequently-occurring patterns and dementia.
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EbioMed | Chinese scholars discovered the important clinical value of cirRNA in the diagnosis and treatment of depression
Time of Update: 2021-05-21
The potential clinical value of circFKBP8 in longitudinal studiesThe potential clinical value of circFKBP8 in longitudinal studiesIn addition, an intervention study on 53 MDD patients showed that antidepressant treatment partially increased the expression of circFKBP8, and the change of circFKBP8 expression could predict a further decrease in HAMD-24 score, that is, antidepressant treatment was effective .
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Stroke: Obstructive sleep apnea is a risk factor for cerebral hemorrhage
Time of Update: 2021-05-21
In order to clear obstructive sleep apnea (OSA) whether the risks associated with intracerebral hemorrhage (ICH), recently, medsci.
do?w=%E5%BF%83%E8%A1%80%E7%AE%A1">Heart blood vesselsEthnic/ethnic differences in cerebral hemorrhage is a multicenter, case-control study that assessed risk factors for ICH.
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Xuanwu Hospital Lu Jie's team published a paper revealing the mystery of the differences between men and women in Alzheimer's disease丨expert perspective
Time of Update: 2021-05-21
In April 2021, the team of Professor Lu Jie from Xuanwu Hospital of Capital Medical University published a research paper entitled "Sex modifies APOE ε4 dose effect on brain taudeposition in cognitively impaired individuals" online on BRAIN.
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Stroke: d-dimer level can be used as a predictor of recurrence in patients with embolic stroke of unknown origin
Time of Update: 2021-05-21
It can be seen that d-dimer level can be used as a useful risk assessment biomarker for predicting recurrent stroke in stroke patients of unknown origin, especially embolic ischemic stroke .
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Safety Science: Drivers with shift work sleep disorders are three times more likely to have a car accident than ordinary people
Time of Update: 2021-05-21
This study used natural driving research data to examine the relationship between clinical sleep disorders (ie shift work sleep disorder (SWSD), sleep apnea, and insomnia) and car accidents.
Diagnosis of excessive daytime sleepiness Reference: Sleep disorders and risk of traffic crashes: A naturalistic driving study analysis DOI: 10.
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Neurology: Neurofeedback technology is conducive to the improvement of gait after stroke
Time of Update: 2021-05-21
The important significance of this study is that the use of fNIRS neurofeedback to promote SMA in motor imagination can enhance gait and balance recovery after stroke by adjusting SMA and its related networks.
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Nat Med: BPN14770 improves the cognitive ability of patients with fragile X syndrome (FXS)
Time of Update: 2021-05-21
The Phase 2 trial is a 24-week randomized, placebo-controlled, two-way crossover study of 30 adult male FXS patients (aged between 18-41 years).
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European Heart Journal: Have a healthier heart and stronger cognitive ability!
Time of Update: 2021-05-21
To investigate the underlying mechanism of the observed relationship, the research team adjusted for potential confounding factors such as age, gender, smoking, education, poverty, diabetes , high blood pressure, high cholesterol , previous myocardial infarction , alcohol intake, and exercise level .
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Circulation: Data from a large cohort study of 2 million people suggest that premature delivery may increase the long-term risk of stroke in women!
Time of Update: 2021-05-21
In the 10 years after delivery, compared with normal pregnant women, the risk of stroke associated with preterm delivery (gestational age <37 weeks) increased by 61% (aHR=1.
052268Preterm Delivery and Long-Term Risk of Stroke in Women: A National Cohort and Cosibling Study.
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NEJM: Left atrial appendage occlusion in patients with atrial fibrillation can effectively prevent stroke
Time of Update: 2021-05-21
In summary, patients with atrial fibrillation undergoing left atrial appendage occlusion can reduce the risk of ischemic stroke or systemic embolism.
In summary, patients with atrial fibrillation undergoing left atrial appendage occlusion can reduce the risk of ischemic stroke or systemic embolism.
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JAHA: The relationship between high-sensitivity cardiac troponin T and recurrent vascular events after the first ischemic stroke
Time of Update: 2021-05-21
The researchers calculated the Cox proportional hazard regression analysis to evaluate the hs-cTnT level (Roche Elecsys, the upper limit of reference is 14ng/L) and the main outcome (recurrent stroke, myocardial infarction, and all-cause death composite event) at the time of study entry Relevance.
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Nature: The brain-computer interface can convert brain activity into text in real time!
Time of Update: 2021-05-21
Recently, researchers from Stanford University in the United States combined artificial intelligence (AI) software with brain-computer interface (BCI) equipment for the first time, and successfully developed an intracortical BCI that decodes neural activity in the motor cortex to try handwritten actions and uses cyclic nerves.
