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Major depressive disorder (MDD) is the most common mental illness with a very high recurrence rate.
Among adult depression patients, 2-8% die by suicide; and about half of suicide victims suffer from depression or other mood disorders.
Risk factors include family medical history, certain drugs, drug abuse, chronic health problems, and major changes in life.
Van Gogh's 1890 "At the Gate of Eternity"
Van Gogh's 1890 "At the Gate of Eternity"In the medical treatment of MDD, only about 30% of patients achieve remission through selective serotonin reuptake inhibitors (SSRIs).
Only about 30% of patients achieve remission with selective serotonin reuptake inhibitors (SSRIs).
In addition to drug therapy, psychotherapy and physical therapy [such as transcranial magnetic stimulation (TMS)] are considered promising strategies for the treatment of MDD.
Circular RNAs (circRNAs) are abundantly expressed in the brain and are related to the pathophysiology of neuropsychiatric diseases.
The researchers performed RNA sequencing on whole blood samples from a discovery group (7 highly homogenous MDD patients and 7 matched healthy controls [HCs]).
Validation and clinical use of circRNAs
Validation and clinical use of circRNAsIn the verification group, the results showed that, compared with 52 HCs, the level of circFKBP8 in 53 MDD patients was significantly decreased (Diff: -0.
In 53 patients with MDD, the expression of circMBNL1 was negatively correlated with the scores of the 24 Hamilton Depression Scale (HAMD-24).
circMBNL1 affects the score of HAMD-24 through a serum brain-derived neurotrophic factor (BDNF).
The potential clinical value of circFKBP8 in longitudinal studies
The potential clinical value of circFKBP8 in longitudinal studiesIn addition, an intervention study on 53 MDD patients showed that antidepressant treatment partially increased the expression of circFKBP8, and the change of circFKBP8 expression could predict a further decrease in HAMD-24 score, that is, antidepressant treatment was effective .
Antidepressant treatment partially increased the expression of circFKBP8, and changes in circFKBP8 expression could predict a further decrease in the HAMD-24 score.
It can be seen that whole blood circFKBP8 and circMBNL1 may be potential biomarkers for the diagnosis of MDD, and circFKBP8 may show great potential in antidepressant treatment.
references:
Potential clinical value of circular RNAs as peripheral biomarkers for the diagnosis and treatment of major depressive disorder.
Potential clinical value of circular RNAs as peripheral biomarkers for the diagnosis and treatment of major depressive disorder.
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