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Nature: FDA approved a landmark new drug, patients are happy, scholars are worried...
Time of Update: 2021-06-22
S. Food and Drug Administration (FDA) approved Aducanumab, the first new drug to treat Alzheimer's disease in 18 years .
Some scientists say that if it proves that reducing the activity of amyloid is sufficient to win regulatory approval, it may prevent researchers from focusing on the huge cognitive improvements needed for patients .
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Want a good night's sleep?
Time of Update: 2021-06-22
"The study found that many people who have the habit of listening to music experience a continuous "earworm effect" and a decline in sleep quality .
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Courier treatment of Alzheimer's disease, Phase 2 clinical results of innovative tau protein vaccine published
Time of Update: 2021-06-22
▎The content team editor of WuXi AppTec today, Axon Neuroscience announced that the complete results of the Phase 2 clinical trial of its tau protein vaccine AADvac1 for the treatment of Alzheimer's disease (AD) were published in the sub-published Nature Aging .
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The team of Li Jia and Zheng Meng of Henan University AS: Using the blood-brain barrier as the target to create a "golden key" for the treatment of brain diseases
Time of Update: 2021-06-22
WILEY paper information: Development of Novel Therapeutics Targeting the Blood–Brain Barrier: From Barrier to CarrierJia Li, Meng Zheng, Olga Shimoni, William A.
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Multiple sclerosis is different in different groups, this drug is more "friendly" to Chinese patients
Time of Update: 2021-06-22
*For medical professionals' reference only, Teriflunomide provides Chinese patients with multiple sclerosis with a combination of curative effects and high satisfaction .
Efficacy and Safety of Teriflunomide in Chinese Patients with Relapsing Forms of Multiple Sclerosis:A Subgroup Analysis of the Phase 3 TOWER Study[J].
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From the moment of weight gain, the blood vessels of the brain are doing things!
Time of Update: 2021-06-22
After specifically knocking out HIF1α on astrocytes, the high-fat and high-sugar diet did not cause the mice to increase blood pressure, nor did it promote the increase of vascular endothelial factor expression in the hypothalamus, nor did it promote the increase of blood vessel density.
109191, the pictures in the text are all from the reference original download link: Baidu Netdisk https://pan.
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Nothing to do with beta amyloid!
Time of Update: 2021-06-22
Researchers focused on Alzheimer's disease's greatest risk genes, ascertained its mechanism of action in mice, and are expected to bring new treatment methods .
Under the action of inhibitors, even if they carry the APOE4 gene, the integrity of the blood-brain barrier in mice can be improved .
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Alzheimer's disease is preventable and controllable, Professor Jia Jianping's 4 points summary
Time of Update: 2021-06-22
At the 7th China Dementia and Cognitive Disorder Academic Conference of the Chinese Medical Association Neurology Branch, Professor Jia Jianping from the Department of Neurology, Xuanwu Hospital, Capital Medical University, gave a wonderful topic on "Alzheimer's Disease Mechanism and Strategic Thinking" Report .
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Cell Sub-Journal: Scientists Reveal a New Type of Hypertensive Neurons
Time of Update: 2021-06-22
6% of the total number of neurons in the DRG region; 38% of TrkC-positive neurons It is co-labeled with Ret neurons expressing mechanoreceptor markers, accounting for about 11.
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Cell Journal: The brain balances how much to eat and precisely regulates blood sugar levels through these two neurons in the intestine
Time of Update: 2021-06-22
After establishing selective intestinal innervation through GLP1R and GPR65 vagus nerve afferents, the research team learned about their feeding and glucose regulation functions .
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Nature Medicine: Patients with colorectal cancer get the new crown vaccine...
Time of Update: 2021-06-22
In this study, the authors reported a case of long-term anti-pd-1 monotherapy in a colorectal cancer patient who developed CRS 5 days after receiving Pfizer-biontech COVID-19 mRNA vaccine BTN162b2 (tozinameran) .
Cytokine release syndrome in a patient with colorectal cancer after vaccination with BNT162b2.
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Popcorn in my mind: intracranial cavernous malformation
Time of Update: 2021-06-22
It is only for medical professionals to read and refer to the imaging manifestations of cerebral cavernous malformations. Source of this article: Department of Radiology, Jiangsu Provincial People's
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Nature's heavyweight: Say goodbye to waist wear!
Time of Update: 2021-06-22
The study showed that compared with people without cognitive problems, all patients with neurodegenerative diseases have higher levels of NfL in the blood, with Down’s syndrome dementia, motor neuron disease, and frontotemporal dementia having the highest concentrations .
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Cell Journal: Restoring miRNA expression can save memory deficits in Alzheimer's disease
Time of Update: 2021-06-22
stem cellFirst, the researchers performed postmortem immunohistochemical analysis on the neuronal progenitor cells proliferating in the subgranular region of the dentate gyrus of the hippocampus in tissue sections of 10 non-dementia control individuals and 10 Alzheimer's disease patients, which confirmed that they are in AD Mid-adult neurogenesis was pathologically damaged, and it was confirmed in a mouse model that the brain pathological damage in AD was related to the level of miR-132 in the adult hippocampal neurogenic niche .
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New drug tour: Lenzilumab-the anti-...
Time of Update: 2021-06-22
Lenzilumab's Phase III randomized placebo controlled trial (NCT04351152) for the treatment of severe and critical COVID-19 pneumonia hospitalized patients was launched in May 2020 .
At that time, Lenzilumab will fill the gap in the market for effective treatment drugs for COVID-19 hospitalized patients .
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Minor head trauma can also cause stroke in children?
Time of Update: 2021-06-22
However, by comparing the MRI results of the outside hospital on the second day of the child’s onset, abnormal signals were seen in the right cerebellar vermis and cerebellar hemisphere, DWI showed obvious high signal (Figure 2), ADC was low signal, and the final diagnosis was the cerebellum caused by trauma.
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IEEE trans: Research on a comprehensive gait rehabilitation assistance platform combined with functional electrical stimulation
Time of Update: 2021-06-21
During the baseline examination, the patient tends to walk with both knees bent during most of the gait cycle, with the largest bending angle appearing on the non-paralyzed side .
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App Envir Micro: a potential antidote for botulism
Time of Update: 2021-06-21
The results show that NPP reverses the activity of botulinum neurotoxin A-induced muscle paralysis in mice .
Tension results show that NPP reverses the activity of botulinum neurotoxin A-induced muscle paralysis in mice .
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Radiology: Look at the cervical spinal cord injury of MS from the MRI perspective
Time of Update: 2021-06-21
In MS patients, multivariate analysis found that phenotype, cervical spinal gray matter (GM) cross-sectional area (CSA), lateral cord anisotropy score (FA), and brain tissue GM volume were independent predictors of EDSS score.
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Stroke: The clinical effect of strengthening comprehensive aphasia intervention on patients with aphasia after stroke
Time of Update: 2021-06-21
It can be seen that after receiving ICAP , patients with aphasia have achieved great and clinically significant benefits in terms of language impairment and functional indicators .
After receiving ICAP, patients with aphasia have achieved great and clinically significant benefits in terms of language impairment and functional indicators .
