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Botulinum neurotoxins (BoNTs) are known human proteins toxic to most, was synthesized from seven different strains of anaerobic bacteria species (serotypes A to G) immunized distinct family of proteins
.
, Its long-lasting paralysis, extreme toxicity, easy production and lack of antidote, make BoNTs a first-level biological threat agent
.
Immunity , its long-lasting paralysis, extreme toxicity, ease of production and lack of antidote, make BoNTs a primary biological threat
Researchers have discovered a compound that strongly inhibits the botulinum neurotoxin, which is one of the most toxic compounds known
In this study, the researchers’ first step was to identify the enzymes in the botulinum neurotoxin that damage neurons and cause paralysis
.
Nitrobenzene Psoralen (NPP)
Nitrobenzene psoralen (3- (.
4-nitrophenyl) -7H-Furo [.
3 , 2-G] chromen--One.
Nitrobenzene psoralen (3- (.
In order to better understand the effect of NPP on BOT/A-mediated muscle paralysis, the researchers stimulated the isolated mouse diaphragmatic phrenic nerve at a frequency of 0.
The time course of BOT/A- mediated muscle inhibition of mouse diaphragm contraction tension is 0.
03 HzBOT / A time course mediated inhibition of mouse diaphragm muscles shrink tension of 0.
diagnosis
These studies show that natural compounds have the potential to become effective botulinum inhibitors
.
In the United States, psoralen-derived drugs have been approved by the FDA, which is likely to speed up the NPP drug approval process
.
These studies show that natural compounds have the potential to become effective botulinum inhibitors
Article reference: Kruti B.
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