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App Envir Micro: a potential antidote for botulism
Time of Update: 2021-06-21
The results show that NPP reverses the activity of botulinum neurotoxin A-induced muscle paralysis in mice .
Tension results show that NPP reverses the activity of botulinum neurotoxin A-induced muscle paralysis in mice .
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Stroke: The clinical effect of strengthening comprehensive aphasia intervention on patients with aphasia after stroke
Time of Update: 2021-06-21
It can be seen that after receiving ICAP , patients with aphasia have achieved great and clinically significant benefits in terms of language impairment and functional indicators .
After receiving ICAP, patients with aphasia have achieved great and clinically significant benefits in terms of language impairment and functional indicators .
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IEEE trans: Research on a comprehensive gait rehabilitation assistance platform combined with functional electrical stimulation
Time of Update: 2021-06-21
During the baseline examination, the patient tends to walk with both knees bent during most of the gait cycle, with the largest bending angle appearing on the non-paralyzed side .
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Alzheimers Dementia: The water exchange rate of the blood-brain barrier is highly correlated with the level of amyloid in the cerebrospinal fluid
Time of Update: 2021-06-21
The results of post-mortem human brain studies and animal models support the hypothesis that the decrease in water exchange across the BBB may be related to the decrease in Aβ clearance in living humans .
These results indicate that the low water exchange rate across the BBB is related to the low CSF Aβ42 concentration .
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Radiology: Single phase or multiple phases?
Time of Update: 2021-06-21
This study shows that in patients with acute ischemic stroke, multi-phase CT angiography can predict the prognosis of patients more accurately than single-phase CT angiography in assessing the state of collateral circulation, and the performance has the same effect as CT perfusion parameters.
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New medicine for major depression (MDD)!
Time of Update: 2021-06-21
News on June 15, 2021 // --Sage Therapeutics and Biogen recently announced that the double-blind placebo-controlled Phase 3 WATERFALL study evaluating the antidepressant zuranolone (SAGE-217/BIIB125) in patients with major depression (MDD) reached the primary endpoint: 17 according to the Hamilton depression Rating scale (HAMD-17) total score at day 15, compared with placebo, patients zuranolone 50mg treatment, depression -like statistically significant and clinically meaningful alleviate .
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NeuroImage: There is age-related weakening of the network synchronization of the brainstem level of the elderly brain state 21
Time of Update: 2021-06-21
A recent publication in the journal NeuroImage shows that there is age-related weakness in the network synchronization of the brainstem level of brain state 21 in the elderly, and it has a negative impact on cortical and subcortical synchronization and working memory performance .
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Alzheimers Dementia: The greater the systolic blood pressure variation, the higher the risk of dementia
Time of Update: 2021-06-21
Lower complexity and higher variability in beat-to -beat systolic blood pressure are associated with elevated long-term risk of dementia: The Rotterdam Study.
Lower complexity and higher variability in beat-to -beat systolic blood pressure are associated with elevated long-term risk of dementia: The Rotterdam Study.
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Alzheimers Dementia: A healthy lifestyle helps prevent dementia
Time of Update: 2021-06-21
Currently, no studies have examined the impact modification of APOE ε4 carriers on the association between LS7 score and dementia risk .
No studies have examined the effect of APOE ε4 carriers on the modification of the association between the LS7 score and the risk of dementia .
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Memory: The age when people have the earliest memory, or from two and a half years old
Time of Update: 2021-06-21
However, recently published in the Memory of a new study in the Journal of the show, humans can recall earliest memories dating back two 2 years and a half, the study results will be the average age of the earliest memories of people for a whole year to postpone the conclusion .
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Neurology: In patients with recurrent multiple sclerosis, age has a greater impact on mortality than disease duration
Time of Update: 2021-06-21
Starting from the current age of 70 years, the value of the excess mortality rate tends to be consistent, regardless of the age at the time of onset, which means that the duration of the disease has no more impact .
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Alzheimers Dementia: People with dementia are more likely to get new crowns, regardless of age
Time of Update: 2021-06-21
Dementia of all causes, especially AD, is related to a higher COVID-19 positive diagnosis and hospitalization risk, regardless of age, and even among people 80 years and older, it is also a powerful risk factor for hospitalized patient severity and death .
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PNAS: Phosphatidylinositol 4,5-bisphosphate consumption is a common feature of cerebral small vessel disease as much as possible
Time of Update: 2021-06-21
Gq G protein-coupled receptors in capillary endothelial cells send signals through phospholipase C (PLC), and long-term stimulation of Gq G protein-coupled receptors will weaken Functional congestion control mechanism based on K+/kir2.
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JAMA Netw Open: Long-term consumption of gluten will not affect cognitive function
Time of Update: 2021-06-21
Recently, a study published in the journal JAMA Netw Open found that in the absence of celiac disease, long-term or short-term intake of gluten has no correlation with cognitive function .
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Neuromodulation: Changes in limbic system function in patients with chronic pancreatitis after 2 weeks of cervical vagus nerve stimulation
Time of Update: 2021-06-21
Therefore, in this paper, in a randomized sham-controlled crossover clinical study of CP patients with chronic abdominal pain, resting state functional magnetic resonance imaging and magnetic resonance spectroscopy were used to describe the brain changes caused by NVN in the neck at two weeks .
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Nat Aging: Alzheimer's disease vaccine is here!
Time of Update: 2021-06-21
ADAMANT: a placebo-controlled randomized phase 2 study of AADvac1, an active immunotherapy against pathological tau in Alzheimer's disease .
Nature ADAMANT: a placebo-controlled randomized phase 2 study of AADvac1, an active immunotherapy against pathological tau in Alzheimer's disease Aging (2 021) Leave a message here
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Stroke: Patients with symptomatic carotid plaque are characterized by increased expression of xanthine oxidase
Time of Update: 2021-06-21
cholesterolIt can be seen that XO overexpression in macrophages is associated with increased serum uric acid and decreased high-density lipoprotein cholesterol levels, and may have a potential role in unstable carotid plaques .
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Alzheimer & Dementia: Indifferent people are not only more prone to dementia, their brain structures are very different!
Time of Update: 2021-06-21
Recently, a study led by a team from the University of Cambridge in the United Kingdom and published in the journal Alzheimer & Dementia conducted a comprehensive analysis of whether apathy can predict changes in the cognitive function of asymptomatic FTD patients .
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Human Brain Mapping: A predictive model based on resting state functional connectivity can predict neuropsychological test performance in later life
Time of Update: 2021-06-21
Use resting state functional connectivity and neuropsychological tests in the OASIS-3 data set (n = 428) to train the predictive model, and apply the identified model iterations to the internal test set (n = 216) and external test set (KSHAP, n = 151) .
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Radiology: Local network efficiency mediates the adverse effect of white matter hyperintensity lesion volume on cognitive function
Time of Update: 2021-06-21
A, MRI scan showed that the white matter hyperintensity (WMH) volume of specific fiber tracts was significantly correlated with the information processing speed score (P, 0.
A, MRI scan showed that the white matter hyperintensity (WMH) volume of specific fiber tracts was significantly correlated with the information processing speed score (P, 0.
