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JNNP: Anti-CD20 monoclonal antibody therapy reduces the humoral immune response to SARS-CoV-2 in patients with multiple sclerosis or optic neuromyelitis
Time of Update: 2021-08-13
In order to improve the understanding of the impact of different DMTs on the immune response to SARS-COV2, this article conducted a prospective study to evaluate the sera of patients with MS or neuromyelitis optica (NMO-SD) who received or did not receive immunomodulatory or immunosuppressive therapy Prevalence and anti-S IgG, anti-S IgA, and anti-N IgG levels .
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Alzheimers Dementia: What are the characteristics of neurofilament light chain proteins in a large population?
Time of Update: 2021-08-13
The Sid O'Bryant team proposed that a multi-level neurodiagnostic process can meet these needs, and shows that a blood-based biomarker profile can be used to detect AD, mild cognitive impairment (MCI), Parkinson’s disease, Lewy body dementia, and The accurate first step for AD and MCI in adults with Down syndrome .
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"Science": Unexpected!
Time of Update: 2021-08-12
Image source: 123RF In this study, a research team from France, through experiments on the visual cortex of mice, revealed the cell process that shuts down during the critical period .
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So difficult: choose chocolate-flavored shit or shit-flavored chocolate?
Time of Update: 2021-08-12
The taste rejected by the fruit flies strongly inhibits the activity of these neurons, meaning that they are responsible for encoding the behavior of food choices .
▲A group of neurons FBl6 was identified in the decision-making center sector of fruit flies to decide which food to eat (picture source: reference [1]).
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PNAS: Math yyds?
Time of Update: 2021-08-12
The level of γ-aminobutyric acid in the frontal middle gyrus is positively correlated with future mathematical reasoning ability.
1. How does the concentration of γ-aminobutyric acid in the middle frontal gyrus affect other cognitive abilities (such as working memory and logic) related to mathematics education?
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Neuron Zhang Zhi/Xu Lin/Jin Yan team reveals that early inflammation induces depression in adolescence
Time of Update: 2021-08-11
Pattern diagram: Early life inflammation increases the phagocytosis of neuronal dendritic spines by ACC microglia, leading to depression-like behaviors in adolescent mice, Dr.
012 Plate maker: Notes for reprinting on the 11th [Non-original article] The copyright of this article belongs to the author of the article.
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Reveal the operating mechanism of the brain to maintain memory, Chinese scientist "Cell" published an article
Time of Update: 2021-08-11
At the same time, the researchers simultaneously recorded the electrical activity of a large population of neurons in the left and right prefrontal cortex of the mice .
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Neuron Shao Lingxiao et al. Reveal the antidepressant mechanism of siloxibin
Time of Update: 2021-08-11
On July 5, 2021, Alex Kwan's team (postdoctoral fellow Shao Lingxiao is the first author) published an article Psilocybin induces rapid and persistent growth of dendritic spines in frontal cortex in vivo on Neuron, using long-term in vivo two-photon imaging technology to monitor The dynamic changes of dendritic spines on the same dendrites before and after a single dose of psilocybin, the first time that psilocybin-induced structural plasticity was found, revealing the time scale of synaptic rewiring .
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Zhang Zhi/Jin Yan/Xu Lin's joint team reveals that excessive phagocytosis of microglia causes depression in adolescence
Time of Update: 2021-08-10
The researchers used the AAV virus in combination with Cx3cr1-cre mice to specifically knock out Cx3cr1 on microglia and can reverse the depression-like behavior disorder caused by LPS, accompanied by the restoration of neuronal function and morphology: ACC brain neuronal activity Increase, dendritic spine density, small excitatory postsynaptic current increase .
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Sub-Journal of "Nature": New Annotation of "Intestinal Fatty Brain Full"
Time of Update: 2021-08-10
A diet high in sugar and fat influences neurotransmitter metabolism and then affects brain function by altering the gut microbiota.
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Cell's "dimensionality reduction blow" from neurons: the decision-making thinking framework of the parietal lobe
Time of Update: 2021-08-10
In the face task, although the LIP neuron reacts the same as the motor task in the case of Tout, in the case of Tin, the lower the visual intensity of the facial stimulus, the higher the firing frequency-as if the more difficult it is to distinguish When the face is a human or a monkey, happy or sad, the more the brain tries to find the answer .
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The state transition of the neural circuit behind the proficient behavior of Cell
Time of Update: 2021-08-10
The synchronous and complex discharges of Purkinje cells are accompanied by rhythmic motor behavior, but it is unknown whether this represents a transition to a coherent dynamical state that coordinates skilled movements .
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IF 40+: The genetic correlation of brain white matter microstructure, brain diseases and cognitive function
Time of Update: 2021-08-10
72) published in Science on June 18, 2021 correlated the genome-wide diffusion magnetic resonance imaging (dMRI) data of 43,802 individuals Research (GWAS), reveals the genetic relationship between white matter microstructure changes and various clinical diseases (such as stroke, depression, schizophrenia, etc.
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Sub-Journal of "Nature": T cells, you are "eating" my brain!
Time of Update: 2021-08-10
Because with age, the optic nerve in the central nervous system has obvious damage-compared with adult (12 months) mice, elderly (24 months) mice have more protection around the optic nerve axons The fragments of the myelin structure of the nerve, the number of axons are reduced, the inner layer of the retina becomes thinner, and the exercise ability and memory of old mice are weakened .
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Cell: Scientists reveal the mechanism of selective pruning of inhibitory synapses in developing microglia
Time of Update: 2021-08-10
In summary, this article found that microglia expressing GABAB receptors can selectively prune inhibitory synapses, if this function is impaired during development and causes adult ADHD .
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Science The glial cell production area in the brain: glial cell reservoir
Time of Update: 2021-08-10
Author Responsible editor in November Enzyme beauty adult mouse brain ventricular-subventricular zone (Ventricular-subventricular zone, V-SVZ) in the quiescent neural stem cells are activated to produce neurons and some glial cells [1] .
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Neuron: Scientists Reveal the Neural Circuits That Smoking Promotes Anxiety
Time of Update: 2021-08-10
In β2 type nAChR knockout mice, nicotine does not cause DA neurons in the VTA brain area to activate or inhibit response, and there is no anxiety-like behavior; however, when β2 type nAChR is specifically expressed in the VTA region, nicotine can exert the above Effect .
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CSA & TISC 2021 ｜Interview with Prof. Xu Anding: The Effect of Antioxidant Therapy on Atherosclerotic Ischemic Stroke
Time of Update: 2021-08-09
Simply put, its etiological classification includes cardiogenic embolism, atherosclerosis-related infarction, inflammation or infarction caused by unknown causes, and small vessel disease-related infarctions mainly with high blood pressure as an important risk factor .
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"Large cerebral hemorrhage and canopy hernia" first aid, this article explains it thoroughly
Time of Update: 2021-08-09
In terms of reducing mortality and vegetative survival rate, emergency minimally invasive surgery is significantly better than conventional treatment of cerebral hemorrhage Craniotomy .
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Research reveals the role and mechanism of α-tubulin trimethylation modification in the development of the nervous system
Time of Update: 2021-08-09
The study revealed that the newly discovered trimethylation modification on α-tubulin can promote the formation of microtubules, thereby regulating the establishment and migration of neuronal polarity .
