Alzheimers Dementia: What are the characteristics of neurofilament light chain proteins in a large population?

Although cerebrospinal fluid (CSF) and positron emission tomography (PET) biomarkers may become the ultimate diagnostic tool for the detection of Alzheimer’s disease (AD) , there is still an urgent need for a cost-effective, non-invasive, and multiple A hierarchical approach to determine who should and should not accept these expensive and more invasive procedures

As the diagnostic framework for AD shifts to AT (N), in addition to amyloid β (A) and tau (T), scientists have also conducted more studies on the utility of neurodegenerative biomarkers (N)

In recent years, a more interesting putative neurodegenerative biomarker is neurofilament light chain (NfL), which is a cytoskeletal protein expressed in large-caliber myelinated axons, axon damage Later, it will be released into the extracellular fluid

Although NfL can be detected throughout the lifespan, it has received much attention as a potential biomarker of AD because many studies have shown increased levels associated with this diagnostic state

Taking into account age and gender, NfL is related to neurodegeneration (P <.

NfL level was significantly correlated with the diagnosis group (normal cognition [NC], mild cognitive impairment [MCI], dementia; P <.

The sensitivity of NfL level for detecting amyloid positive was 0.

The important significance of this study lies in the discovery that plasma NfL levels are greatly affected by age and common medical complications of the elderly , which complicates its utility as a diagnostic biomarker