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Study of Nervous System

Brain: TSPO PET helps to monitor and identify progressive multifocal leukoencephalopathy

 Time of Update: 2021-11-13

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post-IRIS-PMLIn fact, in 3 patients, treatment with rituximab did not affect the uptake of the tracer in the designated PML lesions after Natalizumab-related PML treatment, but multiple sclerosis in the designated active phase Restore the tracer intake to the baseline level in the symptomatic lesions .
Brain: tau protein is related to the pathological progression, disease stage and memory performance of the medial temporal lobe subregions of AD patients

 Time of Update: 2021-11-13

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In the later stages, the accumulation of tau protein in the neocortex, temporal lobe and finally the parietal region of the brain becomes abnormalSecond, in individuals with unimpaired cognitive function, the increase in tau load is related to the local atrophy of the entorhinal cortex, Brodmann 35 area and the anterior hippocampus, while the tau load of several medial anterior temporal lobe subregions is related to the posterior hippocampus.
Brain: Plasma Aβ42/40 and phosphorylated-tau217 help predict the pathological prognosis of Alzheimer's disease

 Time of Update: 2021-11-13

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manageOriginal sourcePlasma markers predict changes in amyloid, tau, atrophy and cognition in non-demented subjects, Brain, Volume 144, Issue 9, September 2021, Pages 2826 –2836, https://doi. 1093/brain/awab163Plasma markers predict changes in amyloid, tau, atrophy and cognition in non-demented subjects, Brain, Volume 144, Issue 9, September 2021, Pages 2826 –2836, https://doi.
JNNP: Early blood pressure reduction after acute cerebral hemorrhage, a systematic review and meta-analysis of individual patient data

 Time of Update: 2021-11-13

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The included trials involved adults (>18 years of age) with acute primary spontaneous cerebral hemorrhage (<7 days); compared with placebo or concurrent guidelines for blood pressure management, fixed activity using oral, sublingual, transdermal or intravenous administration Drugs or intensive, titrated targeted antihypertensive intervention for random participants, using single or combined therapy; and record clinical and/or radiological results.
JNER: Visual feedback improves the illusion of movement caused by tendon vibration after chronic stroke

 Time of Update: 2021-11-13

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The purpose of this study is to test whether visual feedback can improve the movement illusion caused by tendon vibration in chronic stroke patients . Visual feedback improves movement illusions induced by tendon vibration after chronic stroke J NeuroEngineering Rehabil 18, 156 ( 2021).
JAMA Neurol: A lot of physical exercise reduces Parkinson's disease mortality

 Time of Update: 2021-11-13

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The mortality rate of individuals who started PA after receiving a diagnosis of Parkinson's disease is lower than those who are physically inactive This analysis found a dose-response relationship between PA and Parkinson’s disease all-cause mortality .
Alzheimers & Dementia: The impact of persistence on cognition in multi-domain lifestyle interventions (Finger)

 Time of Update: 2021-11-13

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The Finnish Study on Elderly Intervention and Prevention of Cognitive Impairment and Disability (Finger) is the first large-scale multi-domain life>. The Finnish Study on Elderly Intervention and Prevention of Cognitive Impairment and Disability (Finger) is the first large-scale multi-domain life>.
JAMA Neurol: How effective is the intervention for vascular risk factors in preventing dementia?

 Time of Update: 2021-11-13

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Recently, in a multi-field intensive vascular care to prevent dementia (PreDIVA) trial, researchers observed that interventions for vascular risk factors in community elderly people for more than 6-8 years did not significantly reduce the risk of dementia .
Alz Res Therapy: Genetic variation may reveal the underlying mechanism of AD

 Time of Update: 2021-11-13

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analyzed the relationship between variants in the top 30 non-APOE AD risk genes and transcript expression levels in the current large-scale GWAS research, as well as brain amyloidosis, tauopathy and The comprehensive analysis of the pathological process of neurodegeneration uses baseline and follow-up data of CSF, PET, and MRI related to AD .
Double 11 celebration!

 Time of Update: 2021-11-13

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Neurology: BMI affects the degree of disability of peroneal muscular atrophy

 Time of Update: 2021-11-13

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investigated the association between body mass index (BMI) and the disability of children with Charcot-Marie-Tooth disease (CMT) . investigated the association between body mass index (BMI) and the disability of children with Charcot-Marie-Tooth disease (CMT) .
JAMA Neurol: The relationship between the use of enzyme-induced antiepileptic drugs and long-term cardiovascular disease

 Time of Update: 2021-11-13

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The purpose is to: (1) compare the risks associated with EASM and non-EASM; (2) explore the risk of EASMS in strictly defined cases of epileptic events; (3) assess the risk of adverse reactions to long-term use of EASM diagnosed at 65 years of age or older Among the greatest patients, EASMS is at risk .
Radiology: MRI scan allows the progression and outcome of Parkinson's disease in one step!

 Time of Update: 2021-11-13

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Recently, a study published in the Journal of Radiology developed a prediction model based on machine learning, using only the cortical thickness of MRI , combined with clinical information, to assess the risk of PD and MCI patients’ conversion to dementia at an individual level , for PD patients Early diagnosis and disease monitoring provided strong support .
Brain: Early detection and early control of epilepsy in young children

 Time of Update: 2021-11-13

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Original sourceEarly childhood epilepsies: epidemiology, classification, aetiology, and socio-economic determinants, Brain, Volume 144, Issue 9, September 2021, Pages 2879 –2891, https://doi. 1093/brain/awab162Early childhood epilepsies: epidemiology, classification, aetiology, and socio-economic determinants, Brain, Volume 144, Issue 9, September 2021, Pages 2879 –2891, https://doi.
Peking University Research: Borderline hypertension is also exploring the borderline of cognitive decline?

 Time of Update: 2021-11-13

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326; additional file 1: Figure S2 [part A] and Table S4)Compared with the normal blood pressure group, women in the hypertension group had a significantly faster decline in overall cognitive ability (combined β =-0.
A quick look at dry goods, how to deal with burns around the nose and mouth?

 Time of Update: 2021-11-13

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As long as the patient's condition permits, early cutting (cutting) of scabs and skin grafting is the first choice for the treatment of deep facial burns .
JAMA Neurol: The relationship between white matter hyperintensity and the pathology and progression of Parkinson's disease in the elderly

 Time of Update: 2021-11-13

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Brain magnetic resonance imaging (MRI) and autopsy studies have shown that in elderly people without Parkinson's disease, one or more pathological markers of cerebrovascular disease are usually related to the severity of Parkinson's disease .
Alz Res Therapy: Frontotemporal dementia, clinical progress and treatment characteristics

 Time of Update: 2021-11-13

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The purpose is to study the characteristics of FTD patients referred to the network from January 2010 to December 2016, including age of onset, time of diagnosis, clinical manifestations, cognitive progress, and treatment .
Neurology: Explore 100,000 people, what is the disease burden of epilepsy?

 Time of Update: 2021-11-13

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This study showed a high incidence of mental and physical conditions and identified racial and ethnic differences that affect patients with epilepsy . This study showed a high incidence of mental and physical conditions and identified racial and ethnic differences that affect patients with epilepsy .
Brain: Analysis of cerebrospinal fluid helps differential diagnosis of neurological diseases

 Time of Update: 2021-11-13

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This study proves the role of multi-dimensional cerebrospinal fluid analysis in the classification of neurological diseases and endophenotypes in the disease spectrum (such as multiple sclerosis), and has an impact on individualized treatment .

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Study of Nervous System

Brain: TSPO PET helps to monitor and identify progressive multifocal leukoencephalopathy

Brain: tau protein is related to the pathological progression, disease stage and memory performance of the medial temporal lobe subregions of AD patients

Brain: Plasma Aβ42/40 and phosphorylated-tau217 help predict the pathological prognosis of Alzheimer's disease

JNNP: Early blood pressure reduction after acute cerebral hemorrhage, a systematic review and meta-analysis of individual patient data

JNER: Visual feedback improves the illusion of movement caused by tendon vibration after chronic stroke

JAMA Neurol: A lot of physical exercise reduces Parkinson's disease mortality

Alzheimers & Dementia: The impact of persistence on cognition in multi-domain lifestyle interventions (Finger)

JAMA Neurol: How effective is the intervention for vascular risk factors in preventing dementia?

Alz Res Therapy: Genetic variation may reveal the underlying mechanism of AD

Double 11 celebration!

Neurology: BMI affects the degree of disability of peroneal muscular atrophy

JAMA Neurol: The relationship between the use of enzyme-induced antiepileptic drugs and long-term cardiovascular disease

Radiology: MRI scan allows the progression and outcome of Parkinson's disease in one step!

Brain: Early detection and early control of epilepsy in young children

Peking University Research: Borderline hypertension is also exploring the borderline of cognitive decline?

A quick look at dry goods, how to deal with burns around the nose and mouth?

JAMA Neurol: The relationship between white matter hyperintensity and the pathology and progression of Parkinson's disease in the elderly

Alz Res Therapy: Frontotemporal dementia, clinical progress and treatment characteristics

Neurology: Explore 100,000 people, what is the disease burden of epilepsy?

Brain: Analysis of cerebrospinal fluid helps differential diagnosis of neurological diseases