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Recommended Reading: Expert Consensus on Intravascular Treatment of Symptomatic Intracranial Atherosclerotic Stenosis (2022)
Time of Update: 2022-09-30
Guideline Name: Symptomatic intracranial atherosclerotic stenosis Intravascular Treatment Chinese Expert Consensus 2022English:Publisher: Neurointervention Branch of Chinese Stroke SocietyPublished:20
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Rare brain inflammation may provide clues to treating Alzheimer's disease
Time of Update: 2022-09-30
” The researchers analyzed data from patients with a rare autoimmune disease known as cerebral amyloid angiopathy-related inflammation (CAA-ri), in hopes their work will help improve the understanding and treatment of Alzheimer's disease.
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The relationship between serum vitamin D status and antiepileptic therapy in Chinese pediatric epilepsy patients
Time of Update: 2022-09-30
Serum VitD levels in pediatric patients are lower than in healthy children, which may be related to the disease itself, not to ASMs treatment.
Serum VitD levels in pediatric patients are lower than in healthy children, which may be related to the disease itself, not to ASMs treatment.
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Drowsiness is also a disease, for which two academics won this year's "Scientific Breakthrough Award"
Time of Update: 2022-09-30
According to the official website of the Science Breakthrough Prize, Emmanuel Mignot and Masashi Yanagisawa found that narcolepsy is caused by the loss of a small group of brain cells that release arousal-promoting substances.
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JNNP: Application of prescription opioids in multiple sclerosis
Time of Update: 2022-09-30
0 percent of patients with multiple sclerosis but no mood/anxiety disorders took only one opioid, and 8.
0 percent of patients with multiple sclerosis but no mood/anxiety disorders took only one opioid, and 8.
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Treatment of stroke: application of anticoagulant drugs
Time of Update: 2022-09-30
【Indications】It is used to prevent venous embolic disease and venous thrombosis after surgery, to prevent coagulation in vitro circulation during hemodialysis treatment, to treat deep vein thrombosis, and to treat acute unstable angina and non-Q-wave myocardial infarction in combination with aspirin.
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Nat Metab: Does the sun make men eat more? The skin also regulates appetite
Time of Update: 2022-09-30
On July 11, 2022, a study published in Nature Metabolism titled "Food-seeking behavior is triggered by skin ultraviolet exposure in males" noted that UVB irradiation will lead to p53 transcriptional activation in skin fat cells, increased mRNA levels of ghrelin, and increased concentrations of ghrelin in plasma.
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Thrombolytic therapy for acute ischemic stroke
Time of Update: 2022-09-30
(2) Patients with severe stroke caused by occlusion of the middle cerebral artery within 6 hours of onset and who are not suitable for intravenous thrombolysis can undergo arterial thrombolysis in a hospital with conditions after strict selection (grade I recommendation, grade B evidence).
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Dry! The degree of lumbar spondylolisthesis is clearly illustrated
Time of Update: 2022-09-30
The inner edge of the lamina is arched, the vertebral arch and the posterior edge of the vertebral body are enclosed into a foramen, the upper and lower vertebral foramen are connected to form a spinal canal, and the spinal cord and nerves pass through it, and the joint part between the two vertebral bodies is the intervertebral disc, which is composed of two parts: the fibrous ring and the nucleus pulposus.
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JAMA Neurology: Efficacy and safety of rituximab in the treatment of new-onset myasthenia gravis
Time of Update: 2022-09-30
There have been recent studies on the efficacy and safety of rituximab as an add-on to MG standard therapy compared to placebo, the results of which were published in the journal JAMA neurology.
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Neurology: Enhanced imaging and language assessment for the treatment of primary progressive aphasia
Time of Update: 2022-09-30
Recently, a study published in Neurology sought to identify a new behavioral assessment that (1) distinguished logopenic from other variants with high accuracy, and (2) was associated with left superior temporal parietal lobe atrophy (previously shown to be associated with this variant).
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Front.Aging Neurosci: Effects of cerebrospinal fluid neurogranulin and APOE4 on mild cognitive impairment and pathology of Alzheimer's disease
Time of Update: 2022-09-30
The relationship between Ng level and Aβ and Tau in CSFUsing the participant operation curve (ROC) analysis to detect CSF biomarkers associated with clinical diagnosis, CSF Ng, T-tau, and P-tau had higher diagnostic accuracy for MCI and similar accuracy in the AD group.
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From studying piano to studying the brain, Li Wenyu has won two Nobel Prize in science, and her results bring hope to neurodegenerative diseases
Time of Update: 2022-09-30
Li WenyuPrior to this, Li Wenyu also won the 2020 Scientific Breakthrough Award for the discovery of TDP43 protein aggregation in frontotemporal dementia (FTLD) and Frostbite (ALS) and revealed that different forms of α-synuclein (α-Syn) in different cell types are the basis for Parkinson's disease (PD) and multisystem atrophy (MSA).
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Ischemic stroke intravenous thrombolytic therapy, using rt-PA
Time of Update: 2022-09-30
Randomized controlled trials have shown that intravenous rt-PA thrombolysis within 3 hours of the onset of neurologic symptoms in screened patients with acute ischemic stroke is a very effective treatment (class A evidence) at a recommended dose of 0.
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Biomaterials: ALS mutations in human skeletal muscle and motor neurons have different effects on the integrity and function of neuromuscular junctions
Time of Update: 2022-09-30
iPSC-derived NMJ formation between skeletal muscle and motor neuronsThe previous work of the researchers has characterized the function of two SOD1 lines (SOD1L144P and SOD1E100G) and determined that they exhibit reduced myogenicity, myocyclic morphological atrophy, impaired mitochondrial function, and decreased muscle fiber contractility in response to electrical stimulation 。 Next, the researchers co-cultured hSKMWT-hMNWT, hSKMSOD1-hMNWT, hSKMWT-hMNSOD1 and hSKMSOD1-hMNSOD1, including co-cultures paired with a mutant tissue and healthy tissue (i.
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Cerebral atrophy and subcortical arteriosclerotic encephalopathy
Time of Update: 2022-09-30
Physical examination: blood pressure 140/100 mmHg. CT pan scan (Fig. 1-5-1-4-a~c) shows: senile cerebral atrophy5.
Physical examination: blood pressure 140/100 mmHg. CT pan scan (Fig. 1-5-1-4-a~c) shows: senile cerebral atrophy5.
Physical examination: blood pressure 140/100 mmHg. CT pan scan (Fig. 1-5-1-4-a~c) shows: senile cerebral atrophy5.
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Nature back-to-back mechanisms of function-specific regulation of HSP70 and treatment of neurodegenerative diseases
Time of Update: 2022-09-30
Wentink co-published an article entitled Molecular disp of amyloid disaggregation by human HSP70, the authors through nuclear magnetic resonance microscopy and other experiments, found the role of JDPs as a comolecular chaperone in the specific regulation of their binding to HSP70s, The specific molecular mechanism of HSP70 with broad-spectrum biological function was uncovered.
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Movement disorders: In Parkinson's disease, the inhibition of the cortical spinal cord gradually disappears
Time of Update: 2022-09-30
Studies using single pulse transcranial magnetic stimulation (TMS) on M1 in healthy participants have repeatedly observed a brief decrease in the amplitude of motor evoked potentials (MEPs) during exercise preparation, suggesting contradictory inhibition of intracortical spinal tract excitability prior to performing the action.
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PNAS: Caring children may be smarter
Time of Update: 2022-09-30
Figure 2: Quality of care in early life is a potential mechanism to explain the effect of foster care interventions on FSIQ scores at 18 years of age.
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Role of CT and MRI examination of spinal cord injury
Time of Update: 2022-09-30
MRI can clearly show changes in the spine and spinal cord from the longitudinal and transverse directions at the same time, and on the longitudinal lateral tomography, it can clearly show not only the displacement of the vertebral body and the lamina to compress the spinal cord, but also clearly show the spinal cord injury.
