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Stroke: Kawasaki disease may increase the risk of cerebrovascular disease
Time of Update: 2021-12-25
In addition, in the KD cohort, children under 5 years of age had a significantly higher risk of subsequent cerebrovascular disease (adjusted hazard ratio was 3.
This nationwide retrospective cohort study showed that KD may increase the risk of subsequent cerebrovascular diseases, especially those with KD younger than 5 years old .
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NEJM: Tapinarof cream successfully achieved phase III clinical treatment of psoriasis
Time of Update: 2021-12-25
Local treatment with 1% Tapinarof cream once a day can significantly alleviate the symptoms of patients with plaque psoriasis .
Local treatment with 1% Tapinarof cream once a day can significantly alleviate the symptoms of patients with plaque psoriasis .
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NEJM: Humoral immune response weakened within 6 months after vaccination of Covid-19 vaccine BNT162b2
Time of Update: 2021-12-25
The BNT162b2 vaccine caused an increase in IgG levels and a neutralizing antibody response 7 to 14 days after the second dose .
Six months after the second dose of BNT162b2 vaccine, the humoral immune response was significantly reduced, especially in men, people 65 years of age or older, and immunosuppressed people .
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A&R: B cell depletion inhibits fibrosis by inhibiting the differentiation of pro-fibrotic macrophages in a mouse model of systemic sclerosis
Time of Update: 2021-12-25
In addition, B cells from BLM-SSc mice increased the differentiation of pro-fibrotic macrophages in co-culture ( P <0.
In addition, B cells from BLM-SSc mice increased the differentiation of pro-fibrotic macrophages in co-culture ( P <0.
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A&R: Evaluation of the causal relationship between insulin resistance and hyperuricemia and gout using two-way Mendelian randomization
Time of Update: 2021-12-25
Methods : The study used genome-wide association data (serum uric acid [SU] concentration determination n = 288,649 ; gout risk n = 763,813 ; fasting insulin n = 153,525 ) to select genetic tools for 2- sample MR analysis, and use multiple MR methods to solve potential The multi-effect association .
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NEJM: Analysis of the effect of dupiluzumab in the treatment of uncontrolled children with moderate to severe asthma
Time of Update: 2021-12-25
Among children with uncontrolled moderate to severe asthma, children who received dupilumab had fewer asthma attacks and better lung function and asthma control than children who received placebo .
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Lancet Rheumatology: Pain levels and related factors in the Scleroderma Patient-Centered Intervention Network (SPIN) cohort: a multicenter cross-sectional study
Time of Update: 2021-12-25
Evaluate the association of pain intensity and pain interference with systemic sclerosis-related variables and overlap syndrome through multiple linear regression, adjust sociodemographic variables, and standardize continuous independent variables .
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A&R: The value of MRI in assessing the scope of early peripheral spondyloarthritis and predicting recurrence
Time of Update: 2021-12-25
Purpose : This study aims to evaluate the inflammatory burden of peripheral spondyloarthritis (SpA) in the study of early remission induction strategies using tumor necrosis factor (TNF) inhibitors through magnetic resonance imaging (MRI) of the legs .
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A &R: Effect of Atorvastatin on Knee Cartilage Volume in Patients with Symptomatic Knee Osteoarthritis: Results of Randomized Placebo Controlled Trials
Time of Update: 2021-12-25
Purpose : To determine whether atorvastatin can reduce tibial cartilage volume loss in patients with symptomatic knee osteoarthritis (OA) in a multicenter, randomized, double-blind, placebo-controlled trial .
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Case Sharing: Can cold cause urticaria?
Time of Update: 2021-12-25
There will be wind group when exposed to cold air, liquid or objects skin, and sometimes vascular edema vascular quality of lifeHere, we describe a case of severe refractory cold-induced urticaria associated with cryoglobulinemia that was successfully treated with rituximab .
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It hurts everywhere, is it rheumatoid or fibromyalgia?
Time of Update: 2021-12-25
The purpose of treating rheumatoid arthritis with western medicine is to relieve pain or control inflammation, relieve symptoms, control the progress of the disease, maintain finger joint function as much as possible, prevent joint deformities and improve the quality of life of patients .
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NEJM: How effective is Pesolizumab in treating systemic pustular psoriasis?
Time of Update: 2021-12-24
InfectIn this phase 2 randomized trial involving GPP patients, the interleukin-36 receptor inhibitor pesolimab had a higher clearance rate than placebo at 1 week, but it was related to infection and systemic drug reactions .
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SA rectifies its name for cupping?
Time of Update: 2021-12-09
A non-profit academic platform initiated by overseas returnees to share information, integrate resources and exchange academics, occasionally Fengyue's new crown research team from Rutgers University in the United States invented a new method that can safely and effectively boost the immune response generated by nucleic acid vaccines .
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Cell solves a problem 150 years ago!
Time of Update: 2021-12-09
Editor’s note iNature is China’s largest academic official account. It is jointly created by the doctoral team of Tsinghua University, Harvard University, Chinese Academy of Sciences and other units
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[Nature News] Antibodies that can resist the new coronavirus increase with age?
Time of Update: 2021-12-09
Pelletier said when revealing the results of their test: “However, what surprised us most is that those patients aged 50 and above, the antibodies produced in their bodies due to natural infections, provide them with The immune protection ability of the virus is much higher than those of the new crown patients who are less than 50 years old!
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Top issue essentials: rheumatoid arthritis, but also pay attention to this "hidden killer"
Time of Update: 2021-12-09
It is only for medical professionals to read and refer to clinical information.
Citrullinated histone H3, a biomarker of neutrophil extracellular trap formation, predicts the risk of venous thromboembolism in cancer patients[J].
Risk assessment and risk factor analysis of venous thromboembolism in patients with rheumatoid arthritis [D].
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Shanghai University of Science and Technology Institute of Immunochemistry and collaborator AS: Neutralizing antibodies against SARS-CoV-2 S protein were screened from the natural combinatorial antibody library 20 years ago
Time of Update: 2021-12-09
Lerner's group, Shanghai University of Science and Technology Institute of Immunochemistry, aimed at SARS-CoV-2 S protein receptor binding domain (S- RBD), for the fully human natural combinatorial antibody library (collection of B cells with a diversity of >1011) constructed 20 years ago, multiple rounds of competitive screening were carried out using epitope targeting, and 3 high-definition S-RBD antibodies were obtained.
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The ability to resist new coronavirus infection prompts a new vaccine target "Nature" paper
Time of Update: 2021-12-08
A study published by "Nature" Pre-existing polymerase-specific T cells expand in abortive seronegative SARS-CoV-2 pointed out that past exposure to other coronaviruses may increase the body's speed of clearing the new coronavirus (SARS-CoV-2) , Because the immune system can remember viral replication proteins that are highly conserved among different coronaviruses .
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Allergy Huazhong University of Science and Technology Fan Xionglin team found that the knockout of BCG_2432c in the BCG vaccine enhanced autophagy-mediated anti-tuberculosis immunity
Time of Update: 2021-12-08
Editor’s note iNature is China’s largest academic official account. It is jointly created by the doctoral team of Tsinghua University, Harvard University, Chinese Academy of Sciences and other units
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What are the five classic signs of common rheumatism?
Time of Update: 2021-12-08
Figure 2: Dry mouth (picture from the Internet) Figure 3: Rampant dental caries (picture from the Internet) ■ Other symptoms In addition to the above two local manifestations, the superficial parts of SS patients such as the nose, hard palate, trachea and its branches, digestion The exocrine glands of the tract mucosa and vaginal mucosa may be involved, resulting in less secretion and corresponding symptoms .