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Research reveals the role of protein sulfhydryl nitrosylation in antiviral innate immunity
Time of Update: 2021-12-08
Studies have found that nitrosoglutathione reductase (GSNOR) can inhibit the nitrosylation of TBK1 protein, increase the activity of TBK1 phosphokinase, and then promote the expression of interferon (IFN), enhance the body's antiviral immune response, and inhibit the virus Infection .
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Cell Breastfeeding promotes the differentiation of T cells in the direction of anti-inflammatory
Time of Update: 2021-12-08
The article found that breast milk promotes the colonization of bifidobacteria in infants, and promotes the polarization of CD4+ T cells toward Treg and Th1 through the key metabolite ILA, and inhibits mucosal inflammation .
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Which women are more likely to have gout?
Time of Update: 2021-12-08
New evidence shows that just as pro-inflammatory diets are independently associated with increased risk of cardiovascular disease (CVD) and type 2 diabetes (T2D), chronic inflammation may also accelerate the development of patients from hyperuricemia to clinical gout, but improve chronic inflammation in women Whether the external factors (such as diet) improve gout is unclear .
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Sub-Journal of "Science": For the first time, it was discovered that the new crown infection has long-term immune memory, and the effect of the vaccine may be strengthened!
Time of Update: 2021-12-08
The results showed that even after 6 months of infection with the new crown, SARS-CoV-2 specific memory T cells and memory B cells still exist in the patient’s bone marrow, spleen, lung, and multiple lymph nodes, while the lungs and lung-related lymphoid tissues are The most important part of the distribution of these memory cells .
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The first IL-6R monoclonal antibody in China!
Time of Update: 2021-12-08
BAT1806 is a tocilizumab injection developed by Biotech in accordance with the relevant guidelines of China's NMPA, US FDA, and EU EMA biosimilars.
As tocilizumab injection's original molecular protection patent has expired, domestic and foreign pharmaceutical companies have devoted themselves to the research and development of their biosimilar drugs .
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Lancet: To reduce the toxicity and increase the effect, what is the new treatment of "sling" cyclosporine?
Time of Update: 2021-12-07
For medical professionals to read and refer to clinical information only, 1s voclosporin (voclosporin) is a new generation of calcineurin inhibitor (CNi), which can be used to prevent rejection after organ transplantation and treat autoimmunity Disease .
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Can patients use methotrexate/biological agents with "limited" safety data during peri-pregnancy?
Time of Update: 2021-12-07
Figure 4: Some results of MTB medication research during pregnancy have no cause or death: Is it really safe for pregnant women with rheumatism to take medication?
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There are 7 major benefits of early intervention for SLE, how should the diagnosis and treatment plan be optimized?
Time of Update: 2021-12-07
A case-control study of 608 patients (Figure 4) performed a logistic regression analysis of antimalarial treatment and mortality scores to determine whether HCQ also had a protective effect on survival .
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What about coughing and shortness of breath?
Time of Update: 2021-12-07
Sjogren’s syndrome (SS) is an autoimmune disease characterized by involvement of the exocrine glands, and interstitial lung disease (ILD) is one of its common extraglandular manifestations, which not only damages the patient’s body function, but also affects The quality of life can also increase the risk of death [1] .
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Application of imaging technology in the diagnosis and patient management of inflammatory joint disease
Time of Update: 2021-12-07
Metz Medicine invited Professor Zhang Zhuoli, the director of the Department of Rheumatology and Immunology, Peking University First Hospital, to give online lectures to explain the application of imaging technology in the diagnosis and patient management of inflammatory joint diseases.
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The latest consensus of ACR!
Time of Update: 2021-12-07
Common manifestations of lung disease in SS patients include: SS patients without respiratory symptoms; cough; interstitial lung disease (ILD); small nodules; consolidation; Cystic lung disease in SS patients .
An example of the imaging examination results of SS patients with cystic lung disease is shown in Figure 6.
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[Nature] "What you eat is what you eat"-the evidence is found!
Time of Update: 2021-12-07
In addition, the research team found that Bacteroides fragilis changed the structure of its metabolized glycolipid molecules, enabling it to better bind to receptors on specific immune cells and initiate a signal cascade, which ultimately leads to a down-regulation of inflammation .
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How long should the "maintenance treatment" of lupus kidney last?
Time of Update: 2021-12-06
If disease activity needs to be controlled, use glucocorticoids; after reaching a complete clinical response, at least 3-5 years of treatment, you can try to gradually stop the treatment (discontinue glucocorticoids first), Antimalarial drugs should be used continuously for a long time; the purpose of treatment is to protect or improve renal function, and reduce proteinuria by at least 25% within 3 months, reduce by 50% at 6 months, and combine random urine protein within 12 months.
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Current progress in the treatment of primary Sjogren's syndrome
Time of Update: 2021-12-06
Because pro-inflammatory cytokines such as interleukin-6 (IL-6) play a key role in B cell activation and participate in the pathogenesis of pSS, they target Biological preparations of these cytokines may have potential benefits in the treatment of pSS .
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Nature small molecule metabolites also "cross-border"?
Time of Update: 2021-12-06
B cell regulation of anti-tumor immune response.
Reprinting instructions [Original Articles] BioArt original articles, personal forwarding and sharing are welcome, reprinting without permission is prohibited, all published works The copyright is owned by BioArtImmunologic research 57, 115-124, doi:10.
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For patients with "three highs" of gout, ACR recommends eating and treating like this!
Time of Update: 2021-12-06
At the annual meeting of the American Society of Rheumatology (ACR) in 2021, Professor Hyon Choi from Harvard Medical School gave a speech entitled "Gout with Cardiovascular Diseases, Challenges in Drug Management", Department of Rheumatology and Immunology, Huashan Hospital, Fudan University Deputy Chief Physician Zhu Xiaoxia interpreted this topic.
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Taking the medicine at the wrong time, the effect is halved?
Time of Update: 2021-12-06
Making full use of chronopharmacology can fully mobilize the body's active immunity and anti-disease factors by adapting to changes in human biological rhythms, improving the bioavailability and peak concentration of drugs, reducing and avoiding adverse drug reactions, and reducing dosages .
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[Nature Sub-Journal] From the perspective of human genetics-how genetic mutations affect our immune cells, resulting in different severity of COVID-19
Time of Update: 2021-12-06
" This study was published in Nature Communications recently, Researchers published an article titled "COVID-19 genetic risk variants are associated with expression of multiple genes in diverse immune cell types": The scientific community has identified many genetic differences, called polymorphisms, which they call "Severe COVID-19 risk variation" .
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Such rare autoimmune diseases are a little difficult to treat clinically!
Time of Update: 2021-12-06
The preliminary research results of abatacept and small sample case reports indicate that it has a good effect on refractory IIMs and is expected to be developed for clinical treatment of the disease .
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Science Advances Zhejiang University Qing Zhou/Xiamin Yu discovered a new regulatory mechanism for type I interferon production
Time of Update: 2021-12-06
In this study, it was demonstrated that IFN-I was activated in primary cells of patients with otulipenia, and the proteasome component was identified as a substrate for OTULIN-mediated linear deubiquitination .