-
Categories
-
Pharmaceutical Intermediates
-
Active Pharmaceutical Ingredients
-
Food Additives
- Industrial Coatings
- Agrochemicals
- Dyes and Pigments
- Surfactant
- Flavors and Fragrances
- Chemical Reagents
- Catalyst and Auxiliary
- Natural Products
- Inorganic Chemistry
-
Organic Chemistry
-
Biochemical Engineering
- Analytical Chemistry
-
Cosmetic Ingredient
- Water Treatment Chemical
-
Pharmaceutical Intermediates
Promotion
ECHEMI Mall
Wholesale
Weekly Price
Exhibition
News
-
Trade Service
This article is original by Translational Medicine Network.
Please indicate the source for reprinting.
Author: Daisy Guide: Recently, a study published in Nature Communications reveals how genetic mutations associated with severe cases of COVID-19 affect our immune cells.
This is Reveal the power of new pathways related to disease from the perspective of human genetics
.
The scientific community has identified many so-called "severe COVID-19 risk variants.
" Researchers have combined patient genetic data from the COVID-19 host genetic program and immune cell epigenome databases to determine the genes affected by these risk variants And susceptible cell types
.
It was found that a risk variant showed the strongest effect in non-classical monocytes (innate immune cells).
This risk variant caused the cell to reduce the expression of a gene called OAS1
.
The lack of OAS1 expression may reduce the expression of a family of proteins that normally degrade viral RNA and activate the immune system's antiviral response, thereby hindering the body's defenses
.
This may be a potential therapeutic target for COVID-19
.
New research shows how genetic mutations associated with severe cases of COVID-19 affect our immune cells
.
This is the first in-depth study of the relationship between the severity of COVID-19 and gene expression in multiple types of immune cells, led by scientists from the La Jolla Institute of Immunology (LJI) Institute
.
This research can guide the development of new coronavirus therapies to improve immune cell function
.
In their study, the researchers reported that a gene exists in a cell type called non-classical monocytes, which may be a potential therapeutic target for COVID-19
.
"Nature Communications" senior author, Professor LJI, MD Panduragan Vijayanand, said: "This study emphasizes the power of human genetics to reveal new pathways related to disease
.
" This study was published in Nature Communications recently, Researchers published an article titled "COVID-19 genetic risk variants are associated with expression of multiple genes in diverse immune cell types": The scientific community has identified many genetic differences, called polymorphisms, which they call "Severe COVID-19 risk variation"
.
These genetic variants are related to gene expression and seem to affect the severity of the case
.
However, scientists do not know which immune cells are most affected by these risk variants
.
In the study of COVID-19 disease gene epigenesis, Vijayanand and his colleagues combined it with patient genetic data from the COVID-19 host genetic project and LJI's open-access immune cell epigenome database (LICE), To determine the genes and susceptible cell types affected by these risk variants
.
The research team observed 13 subtypes of the human body's key protective and antiviral cells: T cells, B cells, NK cells and monocytes
.
"There are many different immune cell types, and they all play a small role in the overall situation," said Dr.
Benjamin Schmiedel, the first author of the study and a lecturer at LJI.
"We must observe each immune cell type separately to understand how the immune system is.
Respond to the new coronavirus
.
"Researchers have discovered several important associations between genetic variation and genes
.
One of the risk variants affected 12 of the 13 cell types studied
.
This severe COVID-19-risk variant on chromosome 21 is related to decreased expression of a receptor called IFNAR2 on the cell
.
The receptor is part of a signaling pathway that alerts the immune system of infection
.
This new association may help explain why some people cannot develop a strong immune response to SARS-CoV-2
.
At the same time, a risky variant on chromosome 12 showed the strongest effect in non-classical monocytes.
This is a natural immune cell that patrols the body and sends signal molecules to alert other immune cells to threats.
.
This risky variant causes non-classical monocytes to reduce the expression of a gene called OAS1
.
The lack of OAS1 expression may reduce the expression of a family of proteins that normally degrade viral RNA and activate the immune system's antiviral response, thereby hindering the body's defenses
.
Schmiedel said: "Non-classical monocytes are a rare and understudied cell type
.
They only constitute about 2% of immune cells
.
" Schmiedel hopes that the gene expression of COVID-19 disease will be further evaluated in the clinic.
Determine the role of these genes in the pathogenesis of COVID-19
.
He said: "Our ability to identify these genetic mechanisms is a big step forward
.
We can use this information, combined with our immune cell data, to find potential therapeutic targets
.
" Other authors of the study, "COVID-19 Genetic risk variants are associated with the expression of multiple genes in multiple immune cell types," including Job Rocha, Cristian Gonzalez Colin, Sourya Bhattacharyya, Ariel Madrigal, Christian H.
Ottensmeier, Ferhat Ay and Vivek Chandra
.
Reference materials: https://medicalxpress.
com/news/2021-11-covid-case-severity-genetic-differences.
html Note: This article aims to introduce medical research progress and cannot be used as a reference for treatment options
.
If you need health guidance, please go to a regular hospital
.
Recommendation·Activity [Live] WES helps to explore the molecular mechanism of tumor resistance.
Popular·Article Intestinal Microorganisms [Nature] "What you eat is what you eat"-the evidence is found! Biomarkers that reveal how diet ultimately affects immunity through the gut microbiota [Cell Sub-Journal] Non-coding regions of the cancer genome-the discovery of new prognostic biomarkers Single cell sequencing [Cell] Using single cell sequencing technology to analyze recent 600,000 human cells, Ren Bing’s team draws an ultra-large-scale human genome single-cell chromatin accessibility map! Intestinal microbes [BMC sub-Journal] Open a new door to the treatment of gastrointestinal diseases-the discovery of microbiota Tumor research [Science sub Journal] Dr.
Feng Yang from Baylor College of Medicine and his team discovered that MAPK6 gene can promote cancer growth, and targeting MAPK6 provides an effective treatment strategy for cancer! Diseases and health [Cell News] Long-term large amounts of salt are harmful to health! Vigilance: Research reveals for the first time that a high-salt diet will cause trouble to the brain even if it does not increase blood pressure.
Tumor Research [Nature] Edible oil promotes cancer metastasis, and researchers are actively promoting clinical trials of the first new drug!
Please indicate the source for reprinting.
Author: Daisy Guide: Recently, a study published in Nature Communications reveals how genetic mutations associated with severe cases of COVID-19 affect our immune cells.
This is Reveal the power of new pathways related to disease from the perspective of human genetics
.
The scientific community has identified many so-called "severe COVID-19 risk variants.
" Researchers have combined patient genetic data from the COVID-19 host genetic program and immune cell epigenome databases to determine the genes affected by these risk variants And susceptible cell types
.
It was found that a risk variant showed the strongest effect in non-classical monocytes (innate immune cells).
This risk variant caused the cell to reduce the expression of a gene called OAS1
.
The lack of OAS1 expression may reduce the expression of a family of proteins that normally degrade viral RNA and activate the immune system's antiviral response, thereby hindering the body's defenses
.
This may be a potential therapeutic target for COVID-19
.
New research shows how genetic mutations associated with severe cases of COVID-19 affect our immune cells
.
This is the first in-depth study of the relationship between the severity of COVID-19 and gene expression in multiple types of immune cells, led by scientists from the La Jolla Institute of Immunology (LJI) Institute
.
This research can guide the development of new coronavirus therapies to improve immune cell function
.
In their study, the researchers reported that a gene exists in a cell type called non-classical monocytes, which may be a potential therapeutic target for COVID-19
.
"Nature Communications" senior author, Professor LJI, MD Panduragan Vijayanand, said: "This study emphasizes the power of human genetics to reveal new pathways related to disease
.
" This study was published in Nature Communications recently, Researchers published an article titled "COVID-19 genetic risk variants are associated with expression of multiple genes in diverse immune cell types": The scientific community has identified many genetic differences, called polymorphisms, which they call "Severe COVID-19 risk variation"
.
These genetic variants are related to gene expression and seem to affect the severity of the case
.
However, scientists do not know which immune cells are most affected by these risk variants
.
In the study of COVID-19 disease gene epigenesis, Vijayanand and his colleagues combined it with patient genetic data from the COVID-19 host genetic project and LJI's open-access immune cell epigenome database (LICE), To determine the genes and susceptible cell types affected by these risk variants
.
The research team observed 13 subtypes of the human body's key protective and antiviral cells: T cells, B cells, NK cells and monocytes
.
"There are many different immune cell types, and they all play a small role in the overall situation," said Dr.
Benjamin Schmiedel, the first author of the study and a lecturer at LJI.
"We must observe each immune cell type separately to understand how the immune system is.
Respond to the new coronavirus
.
"Researchers have discovered several important associations between genetic variation and genes
.
One of the risk variants affected 12 of the 13 cell types studied
.
This severe COVID-19-risk variant on chromosome 21 is related to decreased expression of a receptor called IFNAR2 on the cell
.
The receptor is part of a signaling pathway that alerts the immune system of infection
.
This new association may help explain why some people cannot develop a strong immune response to SARS-CoV-2
.
At the same time, a risky variant on chromosome 12 showed the strongest effect in non-classical monocytes.
This is a natural immune cell that patrols the body and sends signal molecules to alert other immune cells to threats.
.
This risky variant causes non-classical monocytes to reduce the expression of a gene called OAS1
.
The lack of OAS1 expression may reduce the expression of a family of proteins that normally degrade viral RNA and activate the immune system's antiviral response, thereby hindering the body's defenses
.
Schmiedel said: "Non-classical monocytes are a rare and understudied cell type
.
They only constitute about 2% of immune cells
.
" Schmiedel hopes that the gene expression of COVID-19 disease will be further evaluated in the clinic.
Determine the role of these genes in the pathogenesis of COVID-19
.
He said: "Our ability to identify these genetic mechanisms is a big step forward
.
We can use this information, combined with our immune cell data, to find potential therapeutic targets
.
" Other authors of the study, "COVID-19 Genetic risk variants are associated with the expression of multiple genes in multiple immune cell types," including Job Rocha, Cristian Gonzalez Colin, Sourya Bhattacharyya, Ariel Madrigal, Christian H.
Ottensmeier, Ferhat Ay and Vivek Chandra
.
Reference materials: https://medicalxpress.
com/news/2021-11-covid-case-severity-genetic-differences.
html Note: This article aims to introduce medical research progress and cannot be used as a reference for treatment options
.
If you need health guidance, please go to a regular hospital
.
Recommendation·Activity [Live] WES helps to explore the molecular mechanism of tumor resistance.
Popular·Article Intestinal Microorganisms [Nature] "What you eat is what you eat"-the evidence is found! Biomarkers that reveal how diet ultimately affects immunity through the gut microbiota [Cell Sub-Journal] Non-coding regions of the cancer genome-the discovery of new prognostic biomarkers Single cell sequencing [Cell] Using single cell sequencing technology to analyze recent 600,000 human cells, Ren Bing’s team draws an ultra-large-scale human genome single-cell chromatin accessibility map! Intestinal microbes [BMC sub-Journal] Open a new door to the treatment of gastrointestinal diseases-the discovery of microbiota Tumor research [Science sub Journal] Dr.
Feng Yang from Baylor College of Medicine and his team discovered that MAPK6 gene can promote cancer growth, and targeting MAPK6 provides an effective treatment strategy for cancer! Diseases and health [Cell News] Long-term large amounts of salt are harmful to health! Vigilance: Research reveals for the first time that a high-salt diet will cause trouble to the brain even if it does not increase blood pressure.
Tumor Research [Nature] Edible oil promotes cancer metastasis, and researchers are actively promoting clinical trials of the first new drug!
