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Such rare autoimmune diseases are a little difficult to treat clinically!
Time of Update: 2021-12-06
The preliminary research results of abatacept and small sample case reports indicate that it has a good effect on refractory IIMs and is expected to be developed for clinical treatment of the disease .
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$175 million in license in, Zai Lab's new drug gets new progress
Time of Update: 2021-12-06
On November 15, 2021, Zai Lab announced that Efgartigimod will be used for the treatment of patients with pemphigus vulgaris (PV) or deciduous pemphigus (PF).
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Diagnosing Sjogren’s syndrome, will ultrasound be the next "right assistant"?
Time of Update: 2021-12-06
This time he gave us a wonderful sharing on the role of salivary gland ultrasound (SGUS) in the diagnosis and classification of Sjogren’s syndrome .
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ACR recommendation: Is it more useful than taking medicine?
Time of Update: 2021-12-06
At the "ACR 2021 Youth Committee of the Society of Rheumatology" held by the medical community, Director Zhao Ling from the Department of Rheumatology and Immunology of the First Hospital of Jilin University explained the importance of exercise for patients with spondyloarthritis It also summarized a reasonable exercise plan based on the content of the meeting .
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These 9 gout formulas are too powerful!
Time of Update: 2021-12-06
Purine products are uric acid produced in the body and excretion less attached to the toe joints, swelling, hot, gout, gout [Analysis] In recent years, the domestic diet has become more abundant, and the standard of living has greatly improved , Eat a lot of high-purine foods .
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The lower the LDL-C level, the better?
Time of Update: 2021-12-06
Figure 1: Professor Zhang Na shared the topic "Cardiovascular Complications of Rheumatic Diseases" Cardiologist: The lower the level of LDL-C, the better the risk factors for predicting cardiovascular events include homocysteine and interleukin 6 (IL- 6) Total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), serum soluble intercellular adhesion molecule 1 (slCAM-1), serum amyloid A (SAA), lipoprotein B, TC and high density lipoprotein (HDL-C) ratio, high sensitivity C-reactive protein (hs-CRP) and the like .
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Genetic pedigree shapes the immune response to influenza virus｜Science Weekly Selection
Time of Update: 2021-12-05
A new study designed to explain the different susceptibility to the virus epidemic shows that ancestry and related genetic variation can explain differences in populations’ immune responses to influenza viruses, and can also be used to explain COVID-19 Immune response .
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Nature back-to-back Feng Yuqing/Li Conglei and others reveal the mechanism of antibody production
Time of Update: 2021-12-05
On November 24, 2021, Alberto Martin's team from the Department of Immunology of the University of Toronto in Canada published an article FAM72A antagonizes UNG2 to promote mutagenic repair during antibody maturation in Nature, reporting a major discovery of the mechanism of B cell antibody diversification .
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The world's first approved anti-IL-5 monoclonal antibody came to China to treat eosinophilic granulomatous polyangiitis!
Time of Update: 2021-12-05
▎The content team editor of WuXi AppTec recently, a drug suitable for the treatment of adult patients with eosinophilic granulomatous polyangiitis (EGPA)-mepolizumab injection (English common name: mepolizumab; trade name: new Available), approved by China National Medical Products Administration (NMPA) for marketing .
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Express treatment of autoimmune diseases, bifunctional antibodies show a new mode of suppressing immune response
Time of Update: 2021-12-05
Obexelimab is a new type of bifunctional antibody that simultaneously targets FcγRIIb that inhibits B cell activity and CD19 antigen expressed by B cells for the treatment of autoimmune diseases .
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2 criteria + 3 main symptoms, master the diagnosis of Still disease
Time of Update: 2021-12-05
Still's disease is a group of autoinflammatory diseases, mainly manifested by high fever, joint pain, and skin rash .
Figure 4 X-ray manifestations of Still's disease (left: sJIA; right: AOSD) In the early stage of the disease, 70% of patients may have sore throat, which worsens with fever and relieves fever .
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Nature Immunol Wu Bowen et al. revealed that abnormal aspartic acid metabolism is involved in the occurrence of autoimmune diseases
Time of Update: 2021-12-05
Wu Bowen) published an article Mitochondrial aspartate regulates TNF biogenesis and autoimmune tissue inflammation in Nature Immunology, reporting dysfunction The aspartate shuttle defect caused by mitochondria drives the expansion of the endoplasmic reticulum (ER) of T cells and the oversynthesis of TNF in patients with rheumatoid arthritis .
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Five hematological manifestations of lupus, all in one article!
Time of Update: 2021-12-05
Nancy from Brigham, Harvard Medical School, and Women’s Hospital In the first topic, Professor Berliner explained in detail the contents of SLE-related anemia, neutropenia, and macrophage activation syndrome (MAS) .
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Express BeiGene TYK2 inhibitor enters the clinic, expanding the layout of inflammation and immunology
Time of Update: 2021-12-05
▎The content team editor of WuXi AppTec On November 22, 2021, BeiGene announced that the first patient who has completed Phase 1 clinical trials of the potent tyrosine kinase 2 (TYK2) inhibitor BGB-23339 under investigation has been given to Medicine .
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Is refractory myositis diagnosed after 12 years?
Time of Update: 2021-12-05
However, after following the above treatment for half a year, the doctor found that the patient’s muscle strength was weakened and did not improve, so he couldn’t help but mumble: Is this patient refractory myositis?
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FDA Rheumatism News: 3 new drugs have been approved, and 2 drugs have been "warned"!
Time of Update: 2021-12-05
In this issue, Wang Yuhua, director of the Department of Rheumatology and Immunology, Beijing Shijitan Hospital, Capital Medical University, took us into ACR 2021 and shared the latest news of the FDA on the safety of rheumatism treatment .
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"Osteoporosis" of patients with rheumatism, understand 8 kinds of treatment methods in one article!
Time of Update: 2021-12-05
Therefore, using DXA for diagnosis, condition monitoring and fracture risk assessment of patients with osteoporosis, its safety is guaranteed .
In this regard, Professor He Jing specially shared a table, which is recommended to be collected and memorized: Figure 2: The usage, dosage, adverse reactions and precautions of commonly used prevention and treatment drugs for osteoporosis.
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EHJ: Uric acid-lowering drugs for gout, you have to be aware of this risk!
Time of Update: 2021-12-05
Only for medical professionals to read and refer to clinical information, 1s to reach more cutting-edge clinical information, follow the clinical pharmacy channel to obtain the source of this article
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Updated for the first time in 30 years, the ACR "Vasculitis Classification Standard" is here!
Time of Update: 2021-12-05
5 Classification criteria of aortic arteritis The diagnostic criteria of granulomatous polyangiitis Professor Liu Yanying shared that the criteria is also based on clinical manifestations, laboratory, imaging, and pathological examinations for scoring diagnosis.
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To manage SpA's "cardiovascular comorbidities", master these 4 key points!
Time of Update: 2021-12-05
Director Wang Yu pointed out that this suggests that clinicians also need to pay attention to comorbidities such as cardiovascular disease of radiology-negative axSpA, because there is no difference in the incidence of comorbidities with ankylosing spondylitis .
