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A new study designed to explain the different susceptibility to the virus epidemic shows that ancestry and related genetic variation can explain differences in populations’ immune responses to influenza viruses, and can also be used to explain COVID-19 Immune response
.
In the process of human evolution, viruses are one of the most powerful sources of selection pressure
.
However, before modern times, widespread epidemics may be rare
.
Conversely, the virus outbreak is limited to regional populations
.
Therefore, if past viral epidemics are controlled geographically, they may cause differences in the population’s response to viral infections in their pockets
.
Although ancestry is related to differences in response to the virus, the molecular determinants of these mutations are not yet clear
.
Here, in order to quantify the changes in response to influenza infection, Haley Randolph and colleagues used single-cell RNA sequencing of in vitro peripheral blood monocytes from individuals of European and African genetic ancestry infected with influenza A virus
.
According to Randolph et al.
, infection causes genetic characteristics to differentiate in a cell-type-specific manner, which is related to lineage
.
They found that the overall pattern of the immune response of genetic ancestry, with a clear exception of cell type specificity is the interferon (IFN) response after infection
.
Among all cell types, increased European ancestry is associated with a stronger type I IFN response shortly after influenza infection, which can also predict a drop in virus levels at a later point in time
.
The authors said: “In view of the central role that interferon plays in conferring antiviral activity on host cells, our findings have potential clinical significance for influenza infection and other viruses including SARS-CoV-2.
The time and intensity of the interferon-mediated antiviral response is related to the progression and severity of the disease
.
The study also shows that genes differentially expressed based on genetic lineage are involved in the response to other single-stranded RNA viruses (including SARS-CoV-2), and This finding may help to observe the difference between the susceptibility of African Americans and European Americans to COVID-19
.
Welcome to follow the Science official public account .
Click "Read the original text" below to visit the English original text.
Watch it!
A new study designed to explain the different susceptibility to the virus epidemic shows that ancestry and related genetic variation can explain differences in populations’ immune responses to influenza viruses, and can also be used to explain COVID-19 Immune response
.
In the process of human evolution, viruses are one of the most powerful sources of selection pressure
.
However, before modern times, widespread epidemics may be rare
.
Conversely, the virus outbreak is limited to regional populations
.
Therefore, if past viral epidemics are controlled geographically, they may cause differences in the population’s response to viral infections in their pockets
.
Although ancestry is related to differences in response to the virus, the molecular determinants of these mutations are not yet clear
.
Here, in order to quantify the changes in response to influenza infection, Haley Randolph and colleagues used single-cell RNA sequencing of in vitro peripheral blood monocytes from individuals of European and African genetic ancestry infected with influenza A virus
.
According to Randolph et al.
, infection causes genetic characteristics to differentiate in a cell-type-specific manner, which is related to lineage
.
They found that the overall pattern of the immune response of genetic ancestry, with a clear exception of cell type specificity is the interferon (IFN) response after infection
.
Among all cell types, increased European ancestry is associated with a stronger type I IFN response shortly after influenza infection, which can also predict a drop in virus levels at a later point in time
.
The authors said: “In view of the central role that interferon plays in conferring antiviral activity on host cells, our findings have potential clinical significance for influenza infection and other viruses including SARS-CoV-2.
The time and intensity of the interferon-mediated antiviral response is related to the progression and severity of the disease
.
The study also shows that genes differentially expressed based on genetic lineage are involved in the response to other single-stranded RNA viruses (including SARS-CoV-2), and This finding may help to observe the difference between the susceptibility of African Americans and European Americans to COVID-19
.
Welcome to follow the Science official public account .
Click "Read the original text" below to visit the English original text.
Watch it!
