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Doing a good job in the "disease relief" of RA has these 7 benefits!
Time of Update: 2021-12-05
Studies on the impact on the incidence of severe infections in RA patients have shown that reduced RA disease activity may reduce the risk of severe infections (Figure 2) .
Figure 2: Cl, confidence interval; IRR, incidence rate; LDA, low disease activity; MHDA, moderate to high disease activity; remission: CDAI≤2.
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EULAR definition: refractory rheumatoid arthritis
Time of Update: 2021-12-04
A EULAR working group was established to come up with comprehensive recommendations for addressing unmet needs in the management of refractory (D2T) RAIn the current literature, different terms are used to describe this subgroup of RA patients, for example, severe, refractory, resistant to multiple drugs or treatments, established and difficult to treat .
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Br J Dermatol: Children and Adolescents' Perception of Psoriasis: DIPSOC Study
Time of Update: 2021-12-04
Five criteria were selected as the most helpful in distinguishing psoriasis from other inflammatory skin diseases--mainly atopic eczema--as follows: scales and erythema involving the hairline, external auditory canal, or extension of the elbows and knees; A persistent and well-defined erythematous rash anywhere on the body; a persistent and well-defined erythematous rash .
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NBT︱NeoScreen: A new method for highly sensitive screening of tumor (new) antigens
Time of Update: 2021-12-04
On November 15, 2021, Alexandre Harari's team from the University of Lausanne in Switzerland published an online article entitled Sensitive identification of neoantigens and cognate TCRs in human solid tumors on Nature Biotechnology, and developed a sensitive identification of rare tumor (new) antigens And the method of homologous TCR expressed by tumor-infiltrating lymphocytes-NeoScreen, and confirmed that the tumor antigen-specific TCR-transduced T cells identified by NeoScreen mediate the regression of tumors in xenograft mice derived from patients .
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2021 ACR: Ultrasonic Assessment of Knee Osteoarthritis and Its Consistency with X-ray
Time of Update: 2021-12-04
The visual analog scale (VAS) was used for clinical pain assessment, the Western Ontario and McMaster University Arthritis Index (WOMAC) was used to assess the functional status of all subjects, and the knee joint X- rays and US examinations were accepted .
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EULAR: Pay attention to adverse events related to rheumatic immunity
Time of Update: 2021-12-04
These points considered provide the basis for the European Union Against Rheumatism Consensus on the diagnosis and management of rheumatic and systemic irAEs.
EULAR points to consider for the diagnosis and management of rheumatic immune-related adverse events due to cancer immunotherapy with checkpoint inhibitors.
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2021 ACR: The relationship between intra-articular mineralization on CT of the knee joint and the risk of cartilage loss: a multicenter osteoarthritis study
Time of Update: 2021-12-04
This study focuses on the relationship between IA mineralization on CT (a more sensitive detection method) and MRI cartilage loss in the elderly knee joints , with special attention to the potential joint position and tissue-specific effects of mineralization on cartilage pathology .
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Ann Rheum Dis: Analysis of the Efficacy and Safety of Resalizumab in the Treatment of Active Psoriatic Arthritis
Time of Update: 2021-12-04
Compared with placebo, Rezalizumab treatment can significantly improve the outcome of key diseases, and it is well tolerated by PsA patients with Bio-IR and/or csDMARD-IR .
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2021 ACR: How reliable is it?
Time of Update: 2021-12-04
The purpose of this research is to test the feasibility, reliability and responsiveness of comparing KIMRISS with the established method MOAKS in a multi-reader exercise .
The purpose of this research is to test the feasibility, reliability and responsiveness of comparing KIMRISS with the established method MOAKS in a multi-reader exercise .
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2021 ACR: Using machine learning to predict medial knee cartilage deterioration through gait and physical activity in 2 years: MOST study
Time of Update: 2021-12-04
The goal of the study is to use machine learning in the Multicenter Osteoarthritis Study (MOST) to study the ability of gait and physical activity to predict the deterioration of the medial tibiofemoral cartilage in 2 years .
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Master these 7 points and never worry about injecting biological agents anymore
Time of Update: 2021-12-04
7. What should patients pay attention to?Before injecting biologics, you should consult your doctor or nurse about the precautions after injection, common adverse reactions, and treatment measures.
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JACIP: Research on the treatment of dust mite allergy through sublingual immunotherapy
Time of Update: 2021-12-04
J Allergy Clin Immunol Pract 2021 Nov 09; Langer SS, Cardili RN, Melo JML,Efficacy of House Dust Mite Sublingual Immunotherapy in Patients with Atopic Dermatitis: A Randomized, Double-blind, Placebo-controlled Trial.
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Br J Dermatol: Methotrexate for psoriasis patients with poor treatment effect of Adalizumab
Time of Update: 2021-12-04
The secondary results were PASI50/75/90/100 (percentage of patients whose scores were 50/75/90/100 lower than baseline), PGA response was clear or minimal, and the quality of life index for skin diseases was 0 or 1 .
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Pay attention to the reproductive health of men with rheumatism
Time of Update: 2021-12-04
The treating rheumatologist/rheumatology nurse must consider that the family planning of men and women participating in the ARD clinic requires in-depth consultation and support, so as to agree on a treatment strategy suitable for the patient’s plan and expectations, and guide the patient to adopt the appropriate treatment method and the most Best contraceptive methods and answer their questions .
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Ann Rheum Dis: Inflammatory arthropathy and flu outcome in patients treated with DMARD
Time of Update: 2021-12-04
In absolute terms, the number of COVID-19 cases in patients with IJD exceeds the average seasonal flu, but IJD causes the risk of hospitalization and death for the two infections to increase by 50%-100%, depending on the related mergers.
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2021 ACR Annual Meeting: Systemic lupus erythematosus is a risk factor for death in elderly patients with early breast cancer
Time of Update: 2021-12-03
Kaplan-Meier method and multivariate The Cox proportional hazards model is used to evaluate the association between survival outcomes and the Garris index (for SLE only ) group that adjusts for cancer characteristics and treatment (for BC ), comorbidities, and severity of SLE disease .
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2021ACR Annual Meeting: Increased risk of major adverse cardiac events in patients with systemic lupus erythematosus after non-cardiac surgery
Time of Update: 2021-12-03
After adjusting the preoperative revised cardiac risk index (RCRI) score and race (white, black, Hispanic, Asian, and unknown), a multivariate conditional logistic regression was performed to estimate the incidence of MACE in the three cohorts within one month after surgery Chance .
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How long does it take for a person to accept death?
Time of Update: 2021-12-03
Interstitial lung disease (dermatomyositis, DM) dermatomyositis (DM) polymyositis (PM) polymyositis (PM)ILD patients with positive anti-MDA-5 antibodies usually progress rapidly, and conventional treatment with high-dose glucocorticoids, cyclosporine , tacrolimus, and cyclophosphamide is ineffective .
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Lancet Rheumatology: Evidence for the association between serum urate and acute attacks in patients with gout: a secondary analysis of two randomized controlled trials
Time of Update: 2021-12-02
Research methodsResearch Method Research MethodThe researchers analyzed patient-level data from two randomized trials of uric acid-lowering therapy for gout patients conducted in Nottingham, UK and New Zealand .
The researchers analyzed patient-level data from two randomized trials of uric acid-lowering therapy for gout patients conducted in Nottingham, UK and New Zealand .
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Lancet Rheumatology: Outcomes of COVID-19 in Patients with Primary Systemic Vasculitis or Polymyalgia Rheumatica: A Retrospective Cohort Study
Time of Update: 2021-12-02
Methods Methods : In this retrospective cohort study, 2020 Nian 3 Yue 12 to 2021 Nian 4 Yue 12 the date was diagnosed COVID-19 , there are systemic vasculitis (anti-neutrophil cytoplasmic antibodies [ANCA] Patients with a history of related vasculitis, giant cell arteritis, Behçet’s syndrome or other vasculitis) or polymyalgia rheumatica should be reported to the COVID-19 Global Rheumatism Alliance Registry .
