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A&R: Evaluation of the causal relationship between insulin resistance and hyperuricemia and gout using two-way Mendelian randomization

 Last Update: 2021-12-25
 Source: Internet
 Author: User

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Purpose : Hyperuricemia is closely related to insulin resistance syndrome (and its many cardiometabolic sequelae); however, whether they have a causal relationship has long been controversial
.

This study used two-way Mendelian randomization (MR) analysis to investigate the underlying causal nature and direction between insulin resistance and hyperuricemia and gout

ObjectiveObjective : hyperuricemia and insulin resistance syndrome (and many of cardiometabolic sequelae) are closely related; however, if they have a causal relationship has long been controversial

MethodMethod : The study used genome-wide association data (serum uric acid [the SU] concentration measuring n-= 288,649 ; risk of gout n-= 763,813 ; fasting insulin n-= 153,525 ) is 2 Sample MR analysis selected genetic tools using various MR method to resolve Potential multi-effect association

The resultsresult : genetically determined SU level, whether it is inferred from polygenic score or individual sites, nothing to do with fasting insulin concentration

ConclusionConclusion : These findings provide evidence for the clarification about hyperuricemia and insulin resistance are closely related to the core issues between the syndrome: hyperinsulinemia can cause hyperuricemia, but not vice versa

Source:

McCormick, N.

, O'Connor, MJ, Yokose, C.
, Merriman, TR, Mount, DB, Leong, A.

McCormick, N.

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