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This article is original by Translational Medicine Network.
Please indicate the source for reprinting.
Author: Tiffany Guide: While countries are developing new crown vaccines, people are also questioning how much protection the vaccine can bring to them
.
Recently, a group of scientists conducted in-depth discussions and experiments on the issue of antibodies, and made an amazing discovery from them! Recently, Joelle Pelletier and Jean-François Masson, two professors from the Department of Chemistry at the University of Montreal in Canada, led a research team to conduct an in-depth study of the new crown antibody.
They wanted to compare the natural infection of the new crown and the two methods of vaccination.
Which one is it? This way can bring people more antibodies, allowing them to have more and stronger immunity against the new coronavirus
.
In their experiments, they observed that those who were vaccinated with Pfizer or AstraZeneca had significantly higher levels of antibodies than people who were naturally infected with the new coronavirus
.
In addition, the antibodies produced by these vaccines in their bodies are also effective in resisting and fighting against the Delta mutant virus.
However, when researchers collected samples in 2020, Quebec had not yet been attacked by Delta
.
Masson, a biomedical instrument expert, and Pelletier, a protein chemistry expert, are curious about a group to be studied.
This group is those who have been infected with the new crown but have not been hospitalized.
The two professors want to figure out how this group can do nothing.
What is special about them in the hospital? 32 Canadian adults with COVID-19 who were not hospitalized quickly started a study on it
.
They recruited 32 participants at the Laval University Central Hospital.
These participants were all COVID-19 patients from Canada.
They were all adults.
They had tested positive by PCR 14 to 21 days ago, but none of them Be hospitalized
.
It was still in 2020, before the original strains of the new crown mutated into Beta, Gamma, and Delta
.
Masson said: "Every patient with COVID-19 has antibodies, but there is a big difference in the amount of antibodies produced by adults under 50 and older people over this age.
People over 50 are more likely to develop antibodies than the former.
There will be more antibodies to the new coronavirus, and even 16 weeks after their diagnosis, there are still antibodies in their blood
.
” This picture shows the color scanning electron microscopy of the new coronavirus.
The antibodies produced in the body after the strain) will also have an immune effect on the subsequently mutated new coronavirus mutations.
These mutated viruses include: Beta (South Africa), Delta (India) and Gamma (Brazil), but the degree of immunity is less than vaccination The immune effect brought by the antibodies provided afterwards was reduced by 30% to 50%
.
The defense against the Delta mutant virus is really incredible.
Pelletier said when revealing the results of their test: “However, what surprised us most is that those patients aged 50 and above, the antibodies produced in their bodies due to natural infections, provide them with The immune protection ability of the virus is much higher than those of the new crown patients who are less than 50 years old! We measured the ability of antibodies to inhibit the mutation of Delta.
This mutant virus infects humans through this interaction with ACE-2
.
However, When we measured other mutated new coronaviruses, we did not observe the same pattern
.
"Compared with those who were not vaccinated, people who were vaccinated and slightly infected with the new coronavirus will have one higher level of antibodies in their blood.
Times, the antibodies produced by the vaccine in their bodies can also better prevent the interaction between the spike protein and the ACE-2 receptor
.
Masson also explained: “But what’s more interesting is that among all of these participants, we also have samples from individuals under the age of 49.
They did not produce antibodies that inhibit the spike protein-ACE-2 interaction due to the new crown infection.
Such antibodies are not as effective in their bodies as the antibodies produced by vaccines
.
This shows that if the new crown vaccine is vaccinated, people who have been infected with the original strain of the new crown can increase the defense against the Delta mutant virus
.
" Masson and Pelletier Both scientists believe that they should also conduct more research to determine how to make the best combination to generate the most effective level of antibodies against all mutant viruses
.
They published the results of this research in an article titled "Cross-reactivity of antibodies from non-hospitalized COVID-19 positive individuals against the native, B.
1.
351, B.
1.
617.
2, and P.
1" in the journal Scientific Reports.
SARS-CoV-2 spike proteins" article: Reference: https://medicalxpress.
com/news/2021-11-covid-older-antibodies.
html Note: This article aims to introduce medical research progress and cannot be used as a treatment plan Reference
.
If you need health guidance, please go to a regular hospital
.
Recommendation·Activity Practitioners of Action Knowledge-Seeking Causes of Single-Cell Research and Creation Camp Hot·Article Gene Sequencing [BMJ] Benefits all mankind! The pain of rare disease diagnosis will become history, and whole-genome sequencing is an inevitable trend in medical development! Genetic disease treatment 【Science】The era of RNA drugs has arrived, and the future is boundless! Soon it may bring new insights into cancer treatment [AACR sub-Journal] for patients with rarer genetic diseases! Gastric Cancer Atlas brings new treatment strategies! Scientific research [Science] Transplanting skin and nerves from genetically modified pigs can help humans, but the new era of xenotransplantation has not yet arrived.
New coronavirus [The Lancet] The world's largest study of 12 million people: The new crown vaccine booster is against Delta How much protection can the aspect bring to you? Cancer Treatment [Science Sub-Journal] How to treat non-small cell lung cancer more effectively? Scientists at MIT have discovered a way to bring hope to patients! Novel Coronavirus [Nature Hot Discussion] Will the 28 million children in the United States benefit from the FDA's move? What is the role and significance of children's vaccinations against the new crown?
Please indicate the source for reprinting.
Author: Tiffany Guide: While countries are developing new crown vaccines, people are also questioning how much protection the vaccine can bring to them
.
Recently, a group of scientists conducted in-depth discussions and experiments on the issue of antibodies, and made an amazing discovery from them! Recently, Joelle Pelletier and Jean-François Masson, two professors from the Department of Chemistry at the University of Montreal in Canada, led a research team to conduct an in-depth study of the new crown antibody.
They wanted to compare the natural infection of the new crown and the two methods of vaccination.
Which one is it? This way can bring people more antibodies, allowing them to have more and stronger immunity against the new coronavirus
.
In their experiments, they observed that those who were vaccinated with Pfizer or AstraZeneca had significantly higher levels of antibodies than people who were naturally infected with the new coronavirus
.
In addition, the antibodies produced by these vaccines in their bodies are also effective in resisting and fighting against the Delta mutant virus.
However, when researchers collected samples in 2020, Quebec had not yet been attacked by Delta
.
Masson, a biomedical instrument expert, and Pelletier, a protein chemistry expert, are curious about a group to be studied.
This group is those who have been infected with the new crown but have not been hospitalized.
The two professors want to figure out how this group can do nothing.
What is special about them in the hospital? 32 Canadian adults with COVID-19 who were not hospitalized quickly started a study on it
.
They recruited 32 participants at the Laval University Central Hospital.
These participants were all COVID-19 patients from Canada.
They were all adults.
They had tested positive by PCR 14 to 21 days ago, but none of them Be hospitalized
.
It was still in 2020, before the original strains of the new crown mutated into Beta, Gamma, and Delta
.
Masson said: "Every patient with COVID-19 has antibodies, but there is a big difference in the amount of antibodies produced by adults under 50 and older people over this age.
People over 50 are more likely to develop antibodies than the former.
There will be more antibodies to the new coronavirus, and even 16 weeks after their diagnosis, there are still antibodies in their blood
.
” This picture shows the color scanning electron microscopy of the new coronavirus.
The antibodies produced in the body after the strain) will also have an immune effect on the subsequently mutated new coronavirus mutations.
These mutated viruses include: Beta (South Africa), Delta (India) and Gamma (Brazil), but the degree of immunity is less than vaccination The immune effect brought by the antibodies provided afterwards was reduced by 30% to 50%
.
The defense against the Delta mutant virus is really incredible.
Pelletier said when revealing the results of their test: “However, what surprised us most is that those patients aged 50 and above, the antibodies produced in their bodies due to natural infections, provide them with The immune protection ability of the virus is much higher than those of the new crown patients who are less than 50 years old! We measured the ability of antibodies to inhibit the mutation of Delta.
This mutant virus infects humans through this interaction with ACE-2
.
However, When we measured other mutated new coronaviruses, we did not observe the same pattern
.
"Compared with those who were not vaccinated, people who were vaccinated and slightly infected with the new coronavirus will have one higher level of antibodies in their blood.
Times, the antibodies produced by the vaccine in their bodies can also better prevent the interaction between the spike protein and the ACE-2 receptor
.
Masson also explained: “But what’s more interesting is that among all of these participants, we also have samples from individuals under the age of 49.
They did not produce antibodies that inhibit the spike protein-ACE-2 interaction due to the new crown infection.
Such antibodies are not as effective in their bodies as the antibodies produced by vaccines
.
This shows that if the new crown vaccine is vaccinated, people who have been infected with the original strain of the new crown can increase the defense against the Delta mutant virus
.
" Masson and Pelletier Both scientists believe that they should also conduct more research to determine how to make the best combination to generate the most effective level of antibodies against all mutant viruses
.
They published the results of this research in an article titled "Cross-reactivity of antibodies from non-hospitalized COVID-19 positive individuals against the native, B.
1.
351, B.
1.
617.
2, and P.
1" in the journal Scientific Reports.
SARS-CoV-2 spike proteins" article: Reference: https://medicalxpress.
com/news/2021-11-covid-older-antibodies.
html Note: This article aims to introduce medical research progress and cannot be used as a treatment plan Reference
.
If you need health guidance, please go to a regular hospital
.
Recommendation·Activity Practitioners of Action Knowledge-Seeking Causes of Single-Cell Research and Creation Camp Hot·Article Gene Sequencing [BMJ] Benefits all mankind! The pain of rare disease diagnosis will become history, and whole-genome sequencing is an inevitable trend in medical development! Genetic disease treatment 【Science】The era of RNA drugs has arrived, and the future is boundless! Soon it may bring new insights into cancer treatment [AACR sub-Journal] for patients with rarer genetic diseases! Gastric Cancer Atlas brings new treatment strategies! Scientific research [Science] Transplanting skin and nerves from genetically modified pigs can help humans, but the new era of xenotransplantation has not yet arrived.
New coronavirus [The Lancet] The world's largest study of 12 million people: The new crown vaccine booster is against Delta How much protection can the aspect bring to you? Cancer Treatment [Science Sub-Journal] How to treat non-small cell lung cancer more effectively? Scientists at MIT have discovered a way to bring hope to patients! Novel Coronavirus [Nature Hot Discussion] Will the 28 million children in the United States benefit from the FDA's move? What is the role and significance of children's vaccinations against the new crown?
