-
Categories
-
Pharmaceutical Intermediates
-
Active Pharmaceutical Ingredients
-
Food Additives
- Industrial Coatings
- Agrochemicals
- Dyes and Pigments
- Surfactant
- Flavors and Fragrances
- Chemical Reagents
- Catalyst and Auxiliary
- Natural Products
- Inorganic Chemistry
-
Organic Chemistry
-
Biochemical Engineering
- Analytical Chemistry
-
Cosmetic Ingredient
- Water Treatment Chemical
-
Pharmaceutical Intermediates
Promotion
ECHEMI Mall
Wholesale
Weekly Price
Exhibition
News
-
Trade Service
Despite the high vaccine coverage and effectiveness, the incidence of symptomatic infections with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been increasing in Israel
.
The BNT162b2 vaccine caused an increase in IgG levels and a neutralizing antibody response 7 to 14 days after the second dose
Infection immunity
Recently, a research article was published in the top medical journal NEJM.
Researchers conducted a 6-month longitudinal prospective study involving medical workers who had been vaccinated.
They received monthly anti-spike IgG and neutralization.
Antibody detection
.
The linear mixed model is used to evaluate the dynamic changes of the antibody level and determine the predictor of the antibody level at 6 months
The study included 4868 participants, of which 3808 were included in the linear mixed model analysis
.
The level of IgG antibodies decreased at a consistent rate, while the level of neutralizing antibodies decreased rapidly in the first 3 months, and then decreased relatively slowly
6 months after the second dose, men’s neutralizing antibody titers were significantly lower than women’s (mean ratio 0.
64; 95% confidence interval [CI] 0.
55 to 0.
75), 65 years old or 18 to 45 years old In the population (mean ratio 0.
58; 95% CI 0.
48 to 0.
70), and in immunosuppressed participants lower than those without immunosuppression (mean ratio 0.
30; 95% CI 0.
20 to 0.
46)
.
It can be seen that 6 months after vaccination of the second dose of BNT162b2 vaccine, the humoral immune response was significantly reduced, especially in men, people 65 years of age or older, and immunosuppressed people
.
.
Original source:
Bertram Pitt,et al.
Waning Immune Humoral Response to BNT162b2 Covid-19 Vaccine over 6 Months .
NEJM.