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A study published by "Nature" Pre-existing polymerase-specific T cells expand in abortive seronegative SARS-CoV-2 pointed out that past exposure to other coronaviruses may increase the body's speed of clearing the new coronavirus (SARS-CoV-2) , Because the immune system can remember viral replication proteins that are highly conserved among different coronaviruses
.
The study analyzed medical staff with a higher risk of exposure to SARS-CoV-2.
Although these people had negative SARS-CoV-2 infection or antibody test results, there were signs that they were sensitive to the memory T cells of this conservative complex.
The response has increased, suggesting that they can quickly clear SARS-CoV-2
.
The results of the study suggest that this highly conserved protein can be used as a target for future vaccines against endemic and new coronaviruses
.
SARS-CoV-2 is highly contagious, and some individuals at higher risk of exposure to it will be negative in standard diagnostic tests
.
Previous studies have shown that exposure to coronavirus can produce memory T cells, which may be effective in attenuating SARS-CoV-2 infection
.
Mala Maini of University College London and colleagues hypothesized that since the previously existing memory T cells can recognize the protein of this replication-transcription complex (RTC, a conserved structure involved in viral replication), then these previously existing memory T cells Cells may help quickly control SARS-CoV-2
.
The author believes that simulating the expansion of these cross-reactive T cells in vaccine design may be used to prevent various endemic or emerging coronaviruses.
.
The author studied 58 medical staff in various hospitals in London, England
.
In the first wave of the British epidemic, although these individuals were at high risk of exposure, no one tested positive for SARS-CoV-2 infection
.
The authors compared the T cell response of this cohort with medical staff in the control group who were laboratory-confirmed with SARS-CoV-2 infection
.
Compared to individuals who test positive, individuals who can escape infection appear to have a stronger T cell response, especially for this kind of RTC
.
The new crown-specific T cells tested negative in the serum of medical staff
.
Source: Maini et al.
©NatureNature | doi: 10.
1038/s41586-021-04186-8
.
The study analyzed medical staff with a higher risk of exposure to SARS-CoV-2.
Although these people had negative SARS-CoV-2 infection or antibody test results, there were signs that they were sensitive to the memory T cells of this conservative complex.
The response has increased, suggesting that they can quickly clear SARS-CoV-2
.
The results of the study suggest that this highly conserved protein can be used as a target for future vaccines against endemic and new coronaviruses
.
SARS-CoV-2 is highly contagious, and some individuals at higher risk of exposure to it will be negative in standard diagnostic tests
.
Previous studies have shown that exposure to coronavirus can produce memory T cells, which may be effective in attenuating SARS-CoV-2 infection
.
Mala Maini of University College London and colleagues hypothesized that since the previously existing memory T cells can recognize the protein of this replication-transcription complex (RTC, a conserved structure involved in viral replication), then these previously existing memory T cells Cells may help quickly control SARS-CoV-2
.
The author believes that simulating the expansion of these cross-reactive T cells in vaccine design may be used to prevent various endemic or emerging coronaviruses.
.
The author studied 58 medical staff in various hospitals in London, England
.
In the first wave of the British epidemic, although these individuals were at high risk of exposure, no one tested positive for SARS-CoV-2 infection
.
The authors compared the T cell response of this cohort with medical staff in the control group who were laboratory-confirmed with SARS-CoV-2 infection
.
Compared to individuals who test positive, individuals who can escape infection appear to have a stronger T cell response, especially for this kind of RTC
.
The new crown-specific T cells tested negative in the serum of medical staff
.
Source: Maini et al.
©NatureNature | doi: 10.
1038/s41586-021-04186-8